Porphyrins as Chelating Agents for Molecular Imaging in Nuclear Medicine

Porphyrin ligands, showing a significant affinity for cancer cells, also have the ability to chelate metallic radioisotopes to form potential diagnostic radiopharmaceuticals. They can be applied in single-photon emission computed tomography (SPECT) and positron emission tomography (PET) to evaluate...

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Autores principales: Pyrzynska, Krystyna, Kilian, Krzysztof, Pęgier, Mateusz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9148099/
https://www.ncbi.nlm.nih.gov/pubmed/35630788
http://dx.doi.org/10.3390/molecules27103311
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author Pyrzynska, Krystyna
Kilian, Krzysztof
Pęgier, Mateusz
author_facet Pyrzynska, Krystyna
Kilian, Krzysztof
Pęgier, Mateusz
author_sort Pyrzynska, Krystyna
collection PubMed
description Porphyrin ligands, showing a significant affinity for cancer cells, also have the ability to chelate metallic radioisotopes to form potential diagnostic radiopharmaceuticals. They can be applied in single-photon emission computed tomography (SPECT) and positron emission tomography (PET) to evaluate metabolic changes in the human body for tumor diagnostics. The aim of this paper is to present a short overview of the main metallic radionuclides complexed by porphyrin ligands and used in these techniques. These chelation reactions are discussed in terms of the complexation conditions and kinetics and the complex stability.
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spelling pubmed-91480992022-05-29 Porphyrins as Chelating Agents for Molecular Imaging in Nuclear Medicine Pyrzynska, Krystyna Kilian, Krzysztof Pęgier, Mateusz Molecules Review Porphyrin ligands, showing a significant affinity for cancer cells, also have the ability to chelate metallic radioisotopes to form potential diagnostic radiopharmaceuticals. They can be applied in single-photon emission computed tomography (SPECT) and positron emission tomography (PET) to evaluate metabolic changes in the human body for tumor diagnostics. The aim of this paper is to present a short overview of the main metallic radionuclides complexed by porphyrin ligands and used in these techniques. These chelation reactions are discussed in terms of the complexation conditions and kinetics and the complex stability. MDPI 2022-05-21 /pmc/articles/PMC9148099/ /pubmed/35630788 http://dx.doi.org/10.3390/molecules27103311 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Pyrzynska, Krystyna
Kilian, Krzysztof
Pęgier, Mateusz
Porphyrins as Chelating Agents for Molecular Imaging in Nuclear Medicine
title Porphyrins as Chelating Agents for Molecular Imaging in Nuclear Medicine
title_full Porphyrins as Chelating Agents for Molecular Imaging in Nuclear Medicine
title_fullStr Porphyrins as Chelating Agents for Molecular Imaging in Nuclear Medicine
title_full_unstemmed Porphyrins as Chelating Agents for Molecular Imaging in Nuclear Medicine
title_short Porphyrins as Chelating Agents for Molecular Imaging in Nuclear Medicine
title_sort porphyrins as chelating agents for molecular imaging in nuclear medicine
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9148099/
https://www.ncbi.nlm.nih.gov/pubmed/35630788
http://dx.doi.org/10.3390/molecules27103311
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