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Molecular Analysis in a Glioblastoma Cohort—Results of a Prospective Analysis

The prognostic role of epidermal growth factor receptor variant III (EGFRvIII), a constitutively activated oncogenic receptor, in glioblastoma is controversial. We performed a prospective study enrolling 355 patients operated on for de novo glioblastoma at a large academic center. The molecular prof...

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Autores principales: Lauretti, Liverana, Cenci, Tonia, Montano, Nicola, Offi, Martina, Giordano, Martina, Caccavella, Valerio M., Mangraviti, Antonella, Agostini, Ludovico, Olivi, Alessandro, Gabriele, Lucia, Larocca, Luigi M., Pallini, Roberto, Martini, Maurizio, D’Alessandris, Quintino Giorgio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9148107/
https://www.ncbi.nlm.nih.gov/pubmed/35629107
http://dx.doi.org/10.3390/jpm12050685
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author Lauretti, Liverana
Cenci, Tonia
Montano, Nicola
Offi, Martina
Giordano, Martina
Caccavella, Valerio M.
Mangraviti, Antonella
Agostini, Ludovico
Olivi, Alessandro
Gabriele, Lucia
Larocca, Luigi M.
Pallini, Roberto
Martini, Maurizio
D’Alessandris, Quintino Giorgio
author_facet Lauretti, Liverana
Cenci, Tonia
Montano, Nicola
Offi, Martina
Giordano, Martina
Caccavella, Valerio M.
Mangraviti, Antonella
Agostini, Ludovico
Olivi, Alessandro
Gabriele, Lucia
Larocca, Luigi M.
Pallini, Roberto
Martini, Maurizio
D’Alessandris, Quintino Giorgio
author_sort Lauretti, Liverana
collection PubMed
description The prognostic role of epidermal growth factor receptor variant III (EGFRvIII), a constitutively activated oncogenic receptor, in glioblastoma is controversial. We performed a prospective study enrolling 355 patients operated on for de novo glioblastoma at a large academic center. The molecular profile, including EGFRvIII status, MGMT promoter methylation, and VEGF expression, was assessed. Standard parameters (age, clinical status and extent of surgical resection) were confirmed to hold prognostic value. MGMT promoter methylation portended a slightly improved survival. In the whole series, confirming previous results, EGFRvIII was not associated with worsened prognosis. Interestingly, female sex was associated with a better outcome. Such findings are of interest for the design of future trials.
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spelling pubmed-91481072022-05-29 Molecular Analysis in a Glioblastoma Cohort—Results of a Prospective Analysis Lauretti, Liverana Cenci, Tonia Montano, Nicola Offi, Martina Giordano, Martina Caccavella, Valerio M. Mangraviti, Antonella Agostini, Ludovico Olivi, Alessandro Gabriele, Lucia Larocca, Luigi M. Pallini, Roberto Martini, Maurizio D’Alessandris, Quintino Giorgio J Pers Med Article The prognostic role of epidermal growth factor receptor variant III (EGFRvIII), a constitutively activated oncogenic receptor, in glioblastoma is controversial. We performed a prospective study enrolling 355 patients operated on for de novo glioblastoma at a large academic center. The molecular profile, including EGFRvIII status, MGMT promoter methylation, and VEGF expression, was assessed. Standard parameters (age, clinical status and extent of surgical resection) were confirmed to hold prognostic value. MGMT promoter methylation portended a slightly improved survival. In the whole series, confirming previous results, EGFRvIII was not associated with worsened prognosis. Interestingly, female sex was associated with a better outcome. Such findings are of interest for the design of future trials. MDPI 2022-04-26 /pmc/articles/PMC9148107/ /pubmed/35629107 http://dx.doi.org/10.3390/jpm12050685 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lauretti, Liverana
Cenci, Tonia
Montano, Nicola
Offi, Martina
Giordano, Martina
Caccavella, Valerio M.
Mangraviti, Antonella
Agostini, Ludovico
Olivi, Alessandro
Gabriele, Lucia
Larocca, Luigi M.
Pallini, Roberto
Martini, Maurizio
D’Alessandris, Quintino Giorgio
Molecular Analysis in a Glioblastoma Cohort—Results of a Prospective Analysis
title Molecular Analysis in a Glioblastoma Cohort—Results of a Prospective Analysis
title_full Molecular Analysis in a Glioblastoma Cohort—Results of a Prospective Analysis
title_fullStr Molecular Analysis in a Glioblastoma Cohort—Results of a Prospective Analysis
title_full_unstemmed Molecular Analysis in a Glioblastoma Cohort—Results of a Prospective Analysis
title_short Molecular Analysis in a Glioblastoma Cohort—Results of a Prospective Analysis
title_sort molecular analysis in a glioblastoma cohort—results of a prospective analysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9148107/
https://www.ncbi.nlm.nih.gov/pubmed/35629107
http://dx.doi.org/10.3390/jpm12050685
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