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Molecular Analysis in a Glioblastoma Cohort—Results of a Prospective Analysis
The prognostic role of epidermal growth factor receptor variant III (EGFRvIII), a constitutively activated oncogenic receptor, in glioblastoma is controversial. We performed a prospective study enrolling 355 patients operated on for de novo glioblastoma at a large academic center. The molecular prof...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9148107/ https://www.ncbi.nlm.nih.gov/pubmed/35629107 http://dx.doi.org/10.3390/jpm12050685 |
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author | Lauretti, Liverana Cenci, Tonia Montano, Nicola Offi, Martina Giordano, Martina Caccavella, Valerio M. Mangraviti, Antonella Agostini, Ludovico Olivi, Alessandro Gabriele, Lucia Larocca, Luigi M. Pallini, Roberto Martini, Maurizio D’Alessandris, Quintino Giorgio |
author_facet | Lauretti, Liverana Cenci, Tonia Montano, Nicola Offi, Martina Giordano, Martina Caccavella, Valerio M. Mangraviti, Antonella Agostini, Ludovico Olivi, Alessandro Gabriele, Lucia Larocca, Luigi M. Pallini, Roberto Martini, Maurizio D’Alessandris, Quintino Giorgio |
author_sort | Lauretti, Liverana |
collection | PubMed |
description | The prognostic role of epidermal growth factor receptor variant III (EGFRvIII), a constitutively activated oncogenic receptor, in glioblastoma is controversial. We performed a prospective study enrolling 355 patients operated on for de novo glioblastoma at a large academic center. The molecular profile, including EGFRvIII status, MGMT promoter methylation, and VEGF expression, was assessed. Standard parameters (age, clinical status and extent of surgical resection) were confirmed to hold prognostic value. MGMT promoter methylation portended a slightly improved survival. In the whole series, confirming previous results, EGFRvIII was not associated with worsened prognosis. Interestingly, female sex was associated with a better outcome. Such findings are of interest for the design of future trials. |
format | Online Article Text |
id | pubmed-9148107 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91481072022-05-29 Molecular Analysis in a Glioblastoma Cohort—Results of a Prospective Analysis Lauretti, Liverana Cenci, Tonia Montano, Nicola Offi, Martina Giordano, Martina Caccavella, Valerio M. Mangraviti, Antonella Agostini, Ludovico Olivi, Alessandro Gabriele, Lucia Larocca, Luigi M. Pallini, Roberto Martini, Maurizio D’Alessandris, Quintino Giorgio J Pers Med Article The prognostic role of epidermal growth factor receptor variant III (EGFRvIII), a constitutively activated oncogenic receptor, in glioblastoma is controversial. We performed a prospective study enrolling 355 patients operated on for de novo glioblastoma at a large academic center. The molecular profile, including EGFRvIII status, MGMT promoter methylation, and VEGF expression, was assessed. Standard parameters (age, clinical status and extent of surgical resection) were confirmed to hold prognostic value. MGMT promoter methylation portended a slightly improved survival. In the whole series, confirming previous results, EGFRvIII was not associated with worsened prognosis. Interestingly, female sex was associated with a better outcome. Such findings are of interest for the design of future trials. MDPI 2022-04-26 /pmc/articles/PMC9148107/ /pubmed/35629107 http://dx.doi.org/10.3390/jpm12050685 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Lauretti, Liverana Cenci, Tonia Montano, Nicola Offi, Martina Giordano, Martina Caccavella, Valerio M. Mangraviti, Antonella Agostini, Ludovico Olivi, Alessandro Gabriele, Lucia Larocca, Luigi M. Pallini, Roberto Martini, Maurizio D’Alessandris, Quintino Giorgio Molecular Analysis in a Glioblastoma Cohort—Results of a Prospective Analysis |
title | Molecular Analysis in a Glioblastoma Cohort—Results of a Prospective Analysis |
title_full | Molecular Analysis in a Glioblastoma Cohort—Results of a Prospective Analysis |
title_fullStr | Molecular Analysis in a Glioblastoma Cohort—Results of a Prospective Analysis |
title_full_unstemmed | Molecular Analysis in a Glioblastoma Cohort—Results of a Prospective Analysis |
title_short | Molecular Analysis in a Glioblastoma Cohort—Results of a Prospective Analysis |
title_sort | molecular analysis in a glioblastoma cohort—results of a prospective analysis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9148107/ https://www.ncbi.nlm.nih.gov/pubmed/35629107 http://dx.doi.org/10.3390/jpm12050685 |
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