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Association of Impaired Fasting Glucose and Diabetes with SARS-CoV-2 Spike Antibody Titers after the BNT162b2 Vaccine among Health Care Workers in a Tertiary Hospital in Japan

Background: Hyperglycemia can alter the activation of innate and acquired immunity, but epidemiological evidence linking hyperglycemia to post-vaccination immunogenicity is limited. Objective: To examine the association between SARS-CoV-2 spike antibody titers after the COVID-19 vaccine and impaired...

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Autores principales: Islam, Zobida, Yamamoto, Shohei, Mizoue, Tetsuya, Tanaka, Akihito, Oshiro, Yusuke, Inamura, Natsumi, Konishi, Maki, Ozeki, Mitsuru, Sugiura, Wataru, Ohmagari, Norio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9148122/
https://www.ncbi.nlm.nih.gov/pubmed/35632532
http://dx.doi.org/10.3390/vaccines10050776
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author Islam, Zobida
Yamamoto, Shohei
Mizoue, Tetsuya
Tanaka, Akihito
Oshiro, Yusuke
Inamura, Natsumi
Konishi, Maki
Ozeki, Mitsuru
Sugiura, Wataru
Ohmagari, Norio
author_facet Islam, Zobida
Yamamoto, Shohei
Mizoue, Tetsuya
Tanaka, Akihito
Oshiro, Yusuke
Inamura, Natsumi
Konishi, Maki
Ozeki, Mitsuru
Sugiura, Wataru
Ohmagari, Norio
author_sort Islam, Zobida
collection PubMed
description Background: Hyperglycemia can alter the activation of innate and acquired immunity, but epidemiological evidence linking hyperglycemia to post-vaccination immunogenicity is limited. Objective: To examine the association between SARS-CoV-2 spike antibody titers after the COVID-19 vaccine and impaired fasting glucose (IFG) and diabetes. Methods: Participants were 953 health care workers aged 21–75 years who were tested for SARS-CoV-2 spike IgG antibodies and underwent a health checkup two months after their second dose of the BNT162b2 vaccine. IFG was defined as a fasting plasma glucose (FPG) level of 100–125 mg/dL, and diabetes was defined as an FPG level ≥ 126 mg/dL or being under medical care for diabetes. Multivariable linear regression was used to calculate the ratio of the mean. Result: Spike IgG antibody titers were lower in the presence of hyperglycemia; the ratios of the means (95% CI) were 1.00, 0.79 (0.60–1.04), and 0.60 (0.42–0.87) for individuals with normoglycemia, IFG, and diabetes, respectively (p trend < 0.001). Restricted cubic spline regression analysis showed that IgG spike antibody titers decreased linearly with increasing concentrations of FPG. Conclusion: Diabetes and, to a lesser extent, IFG may be associated with poor humoral immune response after BNT162b2 vaccination.
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spelling pubmed-91481222022-05-29 Association of Impaired Fasting Glucose and Diabetes with SARS-CoV-2 Spike Antibody Titers after the BNT162b2 Vaccine among Health Care Workers in a Tertiary Hospital in Japan Islam, Zobida Yamamoto, Shohei Mizoue, Tetsuya Tanaka, Akihito Oshiro, Yusuke Inamura, Natsumi Konishi, Maki Ozeki, Mitsuru Sugiura, Wataru Ohmagari, Norio Vaccines (Basel) Communication Background: Hyperglycemia can alter the activation of innate and acquired immunity, but epidemiological evidence linking hyperglycemia to post-vaccination immunogenicity is limited. Objective: To examine the association between SARS-CoV-2 spike antibody titers after the COVID-19 vaccine and impaired fasting glucose (IFG) and diabetes. Methods: Participants were 953 health care workers aged 21–75 years who were tested for SARS-CoV-2 spike IgG antibodies and underwent a health checkup two months after their second dose of the BNT162b2 vaccine. IFG was defined as a fasting plasma glucose (FPG) level of 100–125 mg/dL, and diabetes was defined as an FPG level ≥ 126 mg/dL or being under medical care for diabetes. Multivariable linear regression was used to calculate the ratio of the mean. Result: Spike IgG antibody titers were lower in the presence of hyperglycemia; the ratios of the means (95% CI) were 1.00, 0.79 (0.60–1.04), and 0.60 (0.42–0.87) for individuals with normoglycemia, IFG, and diabetes, respectively (p trend < 0.001). Restricted cubic spline regression analysis showed that IgG spike antibody titers decreased linearly with increasing concentrations of FPG. Conclusion: Diabetes and, to a lesser extent, IFG may be associated with poor humoral immune response after BNT162b2 vaccination. MDPI 2022-05-13 /pmc/articles/PMC9148122/ /pubmed/35632532 http://dx.doi.org/10.3390/vaccines10050776 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Islam, Zobida
Yamamoto, Shohei
Mizoue, Tetsuya
Tanaka, Akihito
Oshiro, Yusuke
Inamura, Natsumi
Konishi, Maki
Ozeki, Mitsuru
Sugiura, Wataru
Ohmagari, Norio
Association of Impaired Fasting Glucose and Diabetes with SARS-CoV-2 Spike Antibody Titers after the BNT162b2 Vaccine among Health Care Workers in a Tertiary Hospital in Japan
title Association of Impaired Fasting Glucose and Diabetes with SARS-CoV-2 Spike Antibody Titers after the BNT162b2 Vaccine among Health Care Workers in a Tertiary Hospital in Japan
title_full Association of Impaired Fasting Glucose and Diabetes with SARS-CoV-2 Spike Antibody Titers after the BNT162b2 Vaccine among Health Care Workers in a Tertiary Hospital in Japan
title_fullStr Association of Impaired Fasting Glucose and Diabetes with SARS-CoV-2 Spike Antibody Titers after the BNT162b2 Vaccine among Health Care Workers in a Tertiary Hospital in Japan
title_full_unstemmed Association of Impaired Fasting Glucose and Diabetes with SARS-CoV-2 Spike Antibody Titers after the BNT162b2 Vaccine among Health Care Workers in a Tertiary Hospital in Japan
title_short Association of Impaired Fasting Glucose and Diabetes with SARS-CoV-2 Spike Antibody Titers after the BNT162b2 Vaccine among Health Care Workers in a Tertiary Hospital in Japan
title_sort association of impaired fasting glucose and diabetes with sars-cov-2 spike antibody titers after the bnt162b2 vaccine among health care workers in a tertiary hospital in japan
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9148122/
https://www.ncbi.nlm.nih.gov/pubmed/35632532
http://dx.doi.org/10.3390/vaccines10050776
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