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Silver/Snail Mucous PVA Nanofibers: Electrospun Synthesis and Antibacterial and Wound Healing Activities

Healthcare textiles are gaining great attention in the textile industry. Electrospun nanofibers are considered the golden soldiers due to their strength, flexibility, and eco-friendly properties. The present study aimed to evaluate the potency of polyvinyl alcohol (PVA) nanofibers loaded with newly...

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Autores principales: El-Attar, Aalaa A., El-Wakil, Hamdy B., Hassanin, Ahmed H., Bakr, Basant A., Almutairi, Tahani M., Hagar, Mohamed, Elwakil, Bassma H., Olama, Zakia A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9148169/
https://www.ncbi.nlm.nih.gov/pubmed/35629862
http://dx.doi.org/10.3390/membranes12050536
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author El-Attar, Aalaa A.
El-Wakil, Hamdy B.
Hassanin, Ahmed H.
Bakr, Basant A.
Almutairi, Tahani M.
Hagar, Mohamed
Elwakil, Bassma H.
Olama, Zakia A.
author_facet El-Attar, Aalaa A.
El-Wakil, Hamdy B.
Hassanin, Ahmed H.
Bakr, Basant A.
Almutairi, Tahani M.
Hagar, Mohamed
Elwakil, Bassma H.
Olama, Zakia A.
author_sort El-Attar, Aalaa A.
collection PubMed
description Healthcare textiles are gaining great attention in the textile industry. Electrospun nanofibers are considered the golden soldiers due to their strength, flexibility, and eco-friendly properties. The present study aimed to evaluate the potency of polyvinyl alcohol (PVA) nanofibers loaded with newly biosynthesized silver nanoparticles (Ag-NPs) as a wound healing dressing. Chocolate-band snail (Eobania vermiculata) mucus (which is part of the Mollusca defense system) was used as a novel reducing and stabilizing agent. Data indicated the effectiveness of Eobania vermiculata’s mucus in silver nanoparticle synthesis after a 24 h incubation time. The biosynthesized AgNPs-SM showed a 13.15 nm particle size, −22.5 mV ζ potential, and 0.37 PDI, which proved the stability of the synthesized nanoparticles. Eobania vermiculata mucus and AgNPs-SM showed potent antibacterial activity, especially against Pseudomonas aeruginosa. The electrospinning technique was applied in the fabrication of PVA/AgNPs-SM nanofibers, which were homogenous with a fine diameter of about 100–170 nm and showed a significantly high antimicrobial activity. In vitro and in vivo studies revealed that PVA/AgNPs-SM nanofibers were safe and efficiently enhanced the wound healing process (typical histological picture of the proliferative phase with compact and well aligned collagen fibers in the dermal tissue after 12 days) together with bacterial growth inhibition in the infected skin area.
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spelling pubmed-91481692022-05-29 Silver/Snail Mucous PVA Nanofibers: Electrospun Synthesis and Antibacterial and Wound Healing Activities El-Attar, Aalaa A. El-Wakil, Hamdy B. Hassanin, Ahmed H. Bakr, Basant A. Almutairi, Tahani M. Hagar, Mohamed Elwakil, Bassma H. Olama, Zakia A. Membranes (Basel) Article Healthcare textiles are gaining great attention in the textile industry. Electrospun nanofibers are considered the golden soldiers due to their strength, flexibility, and eco-friendly properties. The present study aimed to evaluate the potency of polyvinyl alcohol (PVA) nanofibers loaded with newly biosynthesized silver nanoparticles (Ag-NPs) as a wound healing dressing. Chocolate-band snail (Eobania vermiculata) mucus (which is part of the Mollusca defense system) was used as a novel reducing and stabilizing agent. Data indicated the effectiveness of Eobania vermiculata’s mucus in silver nanoparticle synthesis after a 24 h incubation time. The biosynthesized AgNPs-SM showed a 13.15 nm particle size, −22.5 mV ζ potential, and 0.37 PDI, which proved the stability of the synthesized nanoparticles. Eobania vermiculata mucus and AgNPs-SM showed potent antibacterial activity, especially against Pseudomonas aeruginosa. The electrospinning technique was applied in the fabrication of PVA/AgNPs-SM nanofibers, which were homogenous with a fine diameter of about 100–170 nm and showed a significantly high antimicrobial activity. In vitro and in vivo studies revealed that PVA/AgNPs-SM nanofibers were safe and efficiently enhanced the wound healing process (typical histological picture of the proliferative phase with compact and well aligned collagen fibers in the dermal tissue after 12 days) together with bacterial growth inhibition in the infected skin area. MDPI 2022-05-20 /pmc/articles/PMC9148169/ /pubmed/35629862 http://dx.doi.org/10.3390/membranes12050536 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
El-Attar, Aalaa A.
El-Wakil, Hamdy B.
Hassanin, Ahmed H.
Bakr, Basant A.
Almutairi, Tahani M.
Hagar, Mohamed
Elwakil, Bassma H.
Olama, Zakia A.
Silver/Snail Mucous PVA Nanofibers: Electrospun Synthesis and Antibacterial and Wound Healing Activities
title Silver/Snail Mucous PVA Nanofibers: Electrospun Synthesis and Antibacterial and Wound Healing Activities
title_full Silver/Snail Mucous PVA Nanofibers: Electrospun Synthesis and Antibacterial and Wound Healing Activities
title_fullStr Silver/Snail Mucous PVA Nanofibers: Electrospun Synthesis and Antibacterial and Wound Healing Activities
title_full_unstemmed Silver/Snail Mucous PVA Nanofibers: Electrospun Synthesis and Antibacterial and Wound Healing Activities
title_short Silver/Snail Mucous PVA Nanofibers: Electrospun Synthesis and Antibacterial and Wound Healing Activities
title_sort silver/snail mucous pva nanofibers: electrospun synthesis and antibacterial and wound healing activities
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9148169/
https://www.ncbi.nlm.nih.gov/pubmed/35629862
http://dx.doi.org/10.3390/membranes12050536
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