Cargando…
Clinical Factors Associated with Serum Magnesium Concentration in Patients Undergoing Peritoneal Dialysis: A Single-Center Observational Study
PURPOSE: Magnesium (Mg) is an essential element that is associated with various physiological functions, such as maintenance of blood pressure, muscle contraction, and nerve function. In patients undergoing hemodialysis, hypomagnesemia is associated with cardiovascular and all-cause mortality. Howev...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9148175/ https://www.ncbi.nlm.nih.gov/pubmed/35637657 http://dx.doi.org/10.2147/IJNRD.S357130 |
_version_ | 1784716988159885312 |
---|---|
author | Kaneko, Shohei Ookawara, Susumu Morishita, Yoshiyuki |
author_facet | Kaneko, Shohei Ookawara, Susumu Morishita, Yoshiyuki |
author_sort | Kaneko, Shohei |
collection | PubMed |
description | PURPOSE: Magnesium (Mg) is an essential element that is associated with various physiological functions, such as maintenance of blood pressure, muscle contraction, and nerve function. In patients undergoing hemodialysis, hypomagnesemia is associated with cardiovascular and all-cause mortality. However, in patients undergoing peritoneal dialysis (PD), clinical factors associated with Mg have not been fully investigated. PATIENTS AND METHODS: Clinical factors including anthropometric data, comorbidities, laboratory data, medications, and dialysis methods were collected from the medical records of patients undergoing PD. The associations of these factors with the serum Mg concentration were investigated by univariate and multivariate analyses. RESULTS: Sixty patients undergoing PD were investigated. The univariate analysis showed that the serum Mg concentration was significantly associated with treatment by hybrid PD (daily PD + once-weekly hemodialysis) (β = 0.264, P = 0.04), administration of phosphate binders (β = 0.294, P = 0.02), the serum C-reactive protein concentration (β = −0.318, P = 0.01), the serum potassium (K) concentration (β = 0.451, P < 0.01), and the serum intact parathormone concentration (β = −0.333, P = 0.01). The multivariate analysis using these factors showed an independent association between the serum Mg and K concentrations (β = 0.333, P = 0.01). CONCLUSION: The serum Mg concentration was independently associated with the serum K concentration in patients undergoing PD. |
format | Online Article Text |
id | pubmed-9148175 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-91481752022-05-29 Clinical Factors Associated with Serum Magnesium Concentration in Patients Undergoing Peritoneal Dialysis: A Single-Center Observational Study Kaneko, Shohei Ookawara, Susumu Morishita, Yoshiyuki Int J Nephrol Renovasc Dis Original Research PURPOSE: Magnesium (Mg) is an essential element that is associated with various physiological functions, such as maintenance of blood pressure, muscle contraction, and nerve function. In patients undergoing hemodialysis, hypomagnesemia is associated with cardiovascular and all-cause mortality. However, in patients undergoing peritoneal dialysis (PD), clinical factors associated with Mg have not been fully investigated. PATIENTS AND METHODS: Clinical factors including anthropometric data, comorbidities, laboratory data, medications, and dialysis methods were collected from the medical records of patients undergoing PD. The associations of these factors with the serum Mg concentration were investigated by univariate and multivariate analyses. RESULTS: Sixty patients undergoing PD were investigated. The univariate analysis showed that the serum Mg concentration was significantly associated with treatment by hybrid PD (daily PD + once-weekly hemodialysis) (β = 0.264, P = 0.04), administration of phosphate binders (β = 0.294, P = 0.02), the serum C-reactive protein concentration (β = −0.318, P = 0.01), the serum potassium (K) concentration (β = 0.451, P < 0.01), and the serum intact parathormone concentration (β = −0.333, P = 0.01). The multivariate analysis using these factors showed an independent association between the serum Mg and K concentrations (β = 0.333, P = 0.01). CONCLUSION: The serum Mg concentration was independently associated with the serum K concentration in patients undergoing PD. Dove 2022-05-24 /pmc/articles/PMC9148175/ /pubmed/35637657 http://dx.doi.org/10.2147/IJNRD.S357130 Text en © 2022 Kaneko et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Original Research Kaneko, Shohei Ookawara, Susumu Morishita, Yoshiyuki Clinical Factors Associated with Serum Magnesium Concentration in Patients Undergoing Peritoneal Dialysis: A Single-Center Observational Study |
title | Clinical Factors Associated with Serum Magnesium Concentration in Patients Undergoing Peritoneal Dialysis: A Single-Center Observational Study |
title_full | Clinical Factors Associated with Serum Magnesium Concentration in Patients Undergoing Peritoneal Dialysis: A Single-Center Observational Study |
title_fullStr | Clinical Factors Associated with Serum Magnesium Concentration in Patients Undergoing Peritoneal Dialysis: A Single-Center Observational Study |
title_full_unstemmed | Clinical Factors Associated with Serum Magnesium Concentration in Patients Undergoing Peritoneal Dialysis: A Single-Center Observational Study |
title_short | Clinical Factors Associated with Serum Magnesium Concentration in Patients Undergoing Peritoneal Dialysis: A Single-Center Observational Study |
title_sort | clinical factors associated with serum magnesium concentration in patients undergoing peritoneal dialysis: a single-center observational study |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9148175/ https://www.ncbi.nlm.nih.gov/pubmed/35637657 http://dx.doi.org/10.2147/IJNRD.S357130 |
work_keys_str_mv | AT kanekoshohei clinicalfactorsassociatedwithserummagnesiumconcentrationinpatientsundergoingperitonealdialysisasinglecenterobservationalstudy AT ookawarasusumu clinicalfactorsassociatedwithserummagnesiumconcentrationinpatientsundergoingperitonealdialysisasinglecenterobservationalstudy AT morishitayoshiyuki clinicalfactorsassociatedwithserummagnesiumconcentrationinpatientsundergoingperitonealdialysisasinglecenterobservationalstudy |