A Rare Case of Pure Primary Large Cell Neuroendocrine Carcinoma of the Gallbladder

Primary large cell neuroendocrine carcinoma (LCNEC) of the gallbladder is a rare malignancy which is often associated with non-LCNEC histologic components. Histologically “pure” LCNECs of the gallbladder are exceedingly rare with only 15 cases reported in the medical literature. Clinically, LCNECs p...

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Autores principales: Shackelford, Rodney E., Ozluk, Ekin, Abdulsattar, Jehan, Lairmore, Terry C., Chu, Quyen, Wei, Eric X.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9148250/
https://www.ncbi.nlm.nih.gov/pubmed/35637677
http://dx.doi.org/10.1155/2022/6956046
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author Shackelford, Rodney E.
Ozluk, Ekin
Abdulsattar, Jehan
Lairmore, Terry C.
Chu, Quyen
Wei, Eric X.
author_facet Shackelford, Rodney E.
Ozluk, Ekin
Abdulsattar, Jehan
Lairmore, Terry C.
Chu, Quyen
Wei, Eric X.
author_sort Shackelford, Rodney E.
collection PubMed
description Primary large cell neuroendocrine carcinoma (LCNEC) of the gallbladder is a rare malignancy which is often associated with non-LCNEC histologic components. Histologically “pure” LCNECs of the gallbladder are exceedingly rare with only 15 cases reported in the medical literature. Clinically, LCNECs present with abdominal pain and jaundice and follow an aggressive course with patients surviving a median of 15 months following initial diagnosis. To our knowledge, we present the 16(th) case of a histologically pure LCNEC in a 62-year-old African American male who was successfully treated surgically. After discharge, he was subsequently lost to follow-up. Due to the extreme rarity of such disease entity, accurate diagnosis and proper management are essential for the best clinical outcome.
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spelling pubmed-91482502022-05-29 A Rare Case of Pure Primary Large Cell Neuroendocrine Carcinoma of the Gallbladder Shackelford, Rodney E. Ozluk, Ekin Abdulsattar, Jehan Lairmore, Terry C. Chu, Quyen Wei, Eric X. Case Rep Oncol Med Case Report Primary large cell neuroendocrine carcinoma (LCNEC) of the gallbladder is a rare malignancy which is often associated with non-LCNEC histologic components. Histologically “pure” LCNECs of the gallbladder are exceedingly rare with only 15 cases reported in the medical literature. Clinically, LCNECs present with abdominal pain and jaundice and follow an aggressive course with patients surviving a median of 15 months following initial diagnosis. To our knowledge, we present the 16(th) case of a histologically pure LCNEC in a 62-year-old African American male who was successfully treated surgically. After discharge, he was subsequently lost to follow-up. Due to the extreme rarity of such disease entity, accurate diagnosis and proper management are essential for the best clinical outcome. Hindawi 2022-05-21 /pmc/articles/PMC9148250/ /pubmed/35637677 http://dx.doi.org/10.1155/2022/6956046 Text en Copyright © 2022 Rodney E. Shackelford et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Shackelford, Rodney E.
Ozluk, Ekin
Abdulsattar, Jehan
Lairmore, Terry C.
Chu, Quyen
Wei, Eric X.
A Rare Case of Pure Primary Large Cell Neuroendocrine Carcinoma of the Gallbladder
title A Rare Case of Pure Primary Large Cell Neuroendocrine Carcinoma of the Gallbladder
title_full A Rare Case of Pure Primary Large Cell Neuroendocrine Carcinoma of the Gallbladder
title_fullStr A Rare Case of Pure Primary Large Cell Neuroendocrine Carcinoma of the Gallbladder
title_full_unstemmed A Rare Case of Pure Primary Large Cell Neuroendocrine Carcinoma of the Gallbladder
title_short A Rare Case of Pure Primary Large Cell Neuroendocrine Carcinoma of the Gallbladder
title_sort rare case of pure primary large cell neuroendocrine carcinoma of the gallbladder
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9148250/
https://www.ncbi.nlm.nih.gov/pubmed/35637677
http://dx.doi.org/10.1155/2022/6956046
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