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1,3,5-triazines inhibit osteosarcoma and avert lung metastasis in a patient-derived orthotopic xenograft mouse model with favorable pharmacokinetics

OBJECTIVE(S): Osteosarcoma is a major solid malignant tumor of bone, possessing significant burden on healthcare due to non-availability of specific anticancer agents. The current study was conducted to identify novel 1,3,5-triazine derivatives against osteosarcoma. MATERIALS AND METHODS: The compou...

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Detalles Bibliográficos
Autores principales: Su, Qing, Xu, Baolin, Tian, Zhoubin, Gong, Ziling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mashhad University of Medical Sciences 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9148403/
https://www.ncbi.nlm.nih.gov/pubmed/35656180
http://dx.doi.org/10.22038/IJBMS.2022.62705.13873