Validation of genomic and transcriptomic models of homologous recombination deficiency in a real-world pan-cancer cohort

BACKGROUND: With the introduction of DNA-damaging therapies into standard of care cancer treatment, there is a growing need for predictive diagnostics assessing homologous recombination deficiency (HRD) status across tumor types. Following the strong clinical evidence for the utility of DNA-sequenci...

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Detalles Bibliográficos
Autores principales: Leibowitz, Benjamin D., Dougherty, Bonnie V., Bell, Joshua S. K., Kapilivsky, Joshuah, Michuda, Jackson, Sedgewick, Andrew J., Munson, Wesley A., Chandra, Tushar A., Dry, Jonathan R., Beaubier, Nike, Igartua, Catherine, Taxter, Timothy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9148513/
https://www.ncbi.nlm.nih.gov/pubmed/35643464
http://dx.doi.org/10.1186/s12885-022-09669-z

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