Inversion of a topological domain leads to restricted changes in its gene expression and affects interdomain communication

The interplay between the topological organization of the genome and the regulation of gene expression remains unclear. Depletion of molecular factors (e.g. CTCF) underlying topologically associating domains (TADs) leads to modest alterations in gene expression, whereas genomic rearrangements involv...

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Detalles Bibliográficos
Autores principales: Galupa, Rafael, Picard, Christel, Servant, Nicolas, Nora, Elphège P., Zhan, Yinxiu, van Bemmel, Joke G., El Marjou, Fatima, Johanneau, Colin, Borensztein, Maud, Ancelin, Katia, Giorgetti, Luca, Heard, Edith
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9148567/
https://www.ncbi.nlm.nih.gov/pubmed/35502750
http://dx.doi.org/10.1242/dev.200568

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