Human pluripotent stem cell-derived kidney organoids for personalized congenital and idiopathic nephrotic syndrome modeling

Nephrotic syndrome (NS) is characterized by severe proteinuria as a consequence of kidney glomerular injury due to podocyte damage. In vitro models mimicking in vivo podocyte characteristics are a prerequisite to resolve NS pathogenesis. The detailed characterization of organoid podocytes resulting...

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Detalles Bibliográficos
Autores principales: Jansen, Jitske, van den Berge, Bartholomeus T., van den Broek, Martijn, Maas, Rutger J., Daviran, Deniz, Willemsen, Brigith, Roverts, Rona, van der Kruit, Marit, Kuppe, Christoph, Reimer, Katharina C., Di Giovanni, Gianluca, Mooren, Fieke, Nlandu, Quincy, Mudde, Helmer, Wetzels, Roy, den Braanker, Dirk, Parr, Naomi, Nagai, James S., Drenic, Vedran, Costa, Ivan G., Steenbergen, Eric, Nijenhuis, Tom, Dijkman, Henry, Endlich, Nicole, van de Kar, Nicole C. A. J., Schneider, Rebekka K., Wetzels, Jack F. M., Akiva, Anat, van der Vlag, Johan, Kramann, Rafael, Schreuder, Michiel F., Smeets, Bart
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2022
Materias:
Human Development
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9148570/
https://www.ncbi.nlm.nih.gov/pubmed/35417019
http://dx.doi.org/10.1242/dev.200198

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