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Clinical presentation of COVID-19 at the time of testing and factors associated with pre-symptomatic cases in Cameroon

OBJECTIVES: To describe the clinical features at time of testing and explore factors associated with SARS-CoV-2 infection and pre-symptomatic cases in Cameroon. METHODS: Data was collected on people in Cameroon who participated in COVID-19 testing by real-time reverse transcriptase-polymerase chain...

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Autores principales: Cyrille, Tejiokem Mathurin, Serge, Sadeuh-Mba, Brice, Tchatchueng Mbougwa Jules, Alain, Tagnouokam Ngoupo Paul, Grace, Ngondi, Joseph, Fokam, Achta, Hamadou, Gisèle, Nke, Julius, Nwobegahay, Marcel, Tongo, Melissa, Sander, Lucy, Ndip, Ronald, Perraut, Claire, Okomo Assoumou Marie, Walter, Pefura Yone Eric, Alain, Etoundi Mballa Georges, Richard, Njouom, Sara, Eyangoh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9148624/
https://www.ncbi.nlm.nih.gov/pubmed/35720960
http://dx.doi.org/10.1016/j.ijregi.2022.05.010
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author Cyrille, Tejiokem Mathurin
Serge, Sadeuh-Mba
Brice, Tchatchueng Mbougwa Jules
Alain, Tagnouokam Ngoupo Paul
Grace, Ngondi
Joseph, Fokam
Achta, Hamadou
Gisèle, Nke
Julius, Nwobegahay
Marcel, Tongo
Melissa, Sander
Lucy, Ndip
Ronald, Perraut
Claire, Okomo Assoumou Marie
Walter, Pefura Yone Eric
Alain, Etoundi Mballa Georges
Richard, Njouom
Sara, Eyangoh
author_facet Cyrille, Tejiokem Mathurin
Serge, Sadeuh-Mba
Brice, Tchatchueng Mbougwa Jules
Alain, Tagnouokam Ngoupo Paul
Grace, Ngondi
Joseph, Fokam
Achta, Hamadou
Gisèle, Nke
Julius, Nwobegahay
Marcel, Tongo
Melissa, Sander
Lucy, Ndip
Ronald, Perraut
Claire, Okomo Assoumou Marie
Walter, Pefura Yone Eric
Alain, Etoundi Mballa Georges
Richard, Njouom
Sara, Eyangoh
author_sort Cyrille, Tejiokem Mathurin
collection PubMed
description OBJECTIVES: To describe the clinical features at time of testing and explore factors associated with SARS-CoV-2 infection and pre-symptomatic cases in Cameroon. METHODS: Data was collected on people in Cameroon who participated in COVID-19 testing by real-time reverse transcriptase-polymerase chain reaction between 1 March and 5 October 2020. After descriptive analysis, multivariate logistic regression was used to identify factors associated with SARS-CoV-2 infection and pre-symptomatic cases. RESULTS: Of 85 206 test participants, 14 863 (17.4%) were infected with SARS-CoV-2. The median age for cases was 38.4 years (interquartile range 29.6−49.4); 6.1% were aged <19 years, and 6.3% were ≥65 years. Of these cases, 46.5% had at least one symptom/sign with a median time from illness onset to testing of 6 days (interquartile range 3−9). Cough (64.2%), headache (46.5%), fatigue/malaise (46.0%), shortness of breath (30.6%) and myalgia/arthralgia (25.6%) were the most commonly observed symptoms/signs. Pre-symptomatic SARS-CoV-2 infection was associated with age <50 years, being male and absence of comorbidities. CONCLUSION: This study provides a comprehensive summary of the early clinical profile of SARS-CoV-2 infection during the first wave of COVID-19 in Cameroon, which was dominated by pre-symptomatic illness. These findings would be helpful for SARS-CoV-2 surveillance and control at a regional level.
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spelling pubmed-91486242022-05-31 Clinical presentation of COVID-19 at the time of testing and factors associated with pre-symptomatic cases in Cameroon Cyrille, Tejiokem Mathurin Serge, Sadeuh-Mba Brice, Tchatchueng Mbougwa Jules Alain, Tagnouokam Ngoupo Paul Grace, Ngondi Joseph, Fokam Achta, Hamadou Gisèle, Nke Julius, Nwobegahay Marcel, Tongo Melissa, Sander Lucy, Ndip Ronald, Perraut Claire, Okomo Assoumou Marie Walter, Pefura Yone Eric Alain, Etoundi Mballa Georges Richard, Njouom Sara, Eyangoh IJID Reg Coronavirus (COVID-19) Collection OBJECTIVES: To describe the clinical features at time of testing and explore factors associated with SARS-CoV-2 infection and pre-symptomatic cases in Cameroon. METHODS: Data was collected on people in Cameroon who participated in COVID-19 testing by real-time reverse transcriptase-polymerase chain reaction between 1 March and 5 October 2020. After descriptive analysis, multivariate logistic regression was used to identify factors associated with SARS-CoV-2 infection and pre-symptomatic cases. RESULTS: Of 85 206 test participants, 14 863 (17.4%) were infected with SARS-CoV-2. The median age for cases was 38.4 years (interquartile range 29.6−49.4); 6.1% were aged <19 years, and 6.3% were ≥65 years. Of these cases, 46.5% had at least one symptom/sign with a median time from illness onset to testing of 6 days (interquartile range 3−9). Cough (64.2%), headache (46.5%), fatigue/malaise (46.0%), shortness of breath (30.6%) and myalgia/arthralgia (25.6%) were the most commonly observed symptoms/signs. Pre-symptomatic SARS-CoV-2 infection was associated with age <50 years, being male and absence of comorbidities. CONCLUSION: This study provides a comprehensive summary of the early clinical profile of SARS-CoV-2 infection during the first wave of COVID-19 in Cameroon, which was dominated by pre-symptomatic illness. These findings would be helpful for SARS-CoV-2 surveillance and control at a regional level. Elsevier 2022-05-29 /pmc/articles/PMC9148624/ /pubmed/35720960 http://dx.doi.org/10.1016/j.ijregi.2022.05.010 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Coronavirus (COVID-19) Collection
Cyrille, Tejiokem Mathurin
Serge, Sadeuh-Mba
Brice, Tchatchueng Mbougwa Jules
Alain, Tagnouokam Ngoupo Paul
Grace, Ngondi
Joseph, Fokam
Achta, Hamadou
Gisèle, Nke
Julius, Nwobegahay
Marcel, Tongo
Melissa, Sander
Lucy, Ndip
Ronald, Perraut
Claire, Okomo Assoumou Marie
Walter, Pefura Yone Eric
Alain, Etoundi Mballa Georges
Richard, Njouom
Sara, Eyangoh
Clinical presentation of COVID-19 at the time of testing and factors associated with pre-symptomatic cases in Cameroon
title Clinical presentation of COVID-19 at the time of testing and factors associated with pre-symptomatic cases in Cameroon
title_full Clinical presentation of COVID-19 at the time of testing and factors associated with pre-symptomatic cases in Cameroon
title_fullStr Clinical presentation of COVID-19 at the time of testing and factors associated with pre-symptomatic cases in Cameroon
title_full_unstemmed Clinical presentation of COVID-19 at the time of testing and factors associated with pre-symptomatic cases in Cameroon
title_short Clinical presentation of COVID-19 at the time of testing and factors associated with pre-symptomatic cases in Cameroon
title_sort clinical presentation of covid-19 at the time of testing and factors associated with pre-symptomatic cases in cameroon
topic Coronavirus (COVID-19) Collection
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9148624/
https://www.ncbi.nlm.nih.gov/pubmed/35720960
http://dx.doi.org/10.1016/j.ijregi.2022.05.010
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