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The CANOVA Study Real-World Evidence of Biologic Treatments in Moderate-Severe Psoriasis in Italy: A Gender Perspective
BACKGROUND: In psoriasis, several studies have indicated sex differences in clinical characteristics, type of treatment, and outcomes. A higher impact of psoriasis on quality of life (QoL) and a lower treatment satisfaction have been reported in women by different authors. OBJECTIVES: This article r...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Mary Ann Liebert, Inc., publishers
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9148641/ https://www.ncbi.nlm.nih.gov/pubmed/35651996 http://dx.doi.org/10.1089/whr.2021.0124 |
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author | Colombo, Delia Bianchi, Luca Fabbrocini, Gabriella Corrao, Salvatore Offidani, Annamaria Stingeni, Luca Costanzo, Antonio Pellacani, Giovanni Peris, Ketty Bardazzi, Federico Argenziano, Giuseppe Ruffolo, Silvana Dapavo, Paolo Carrera, Carlo Fargnoli, Maria Concetta Parodi, Aurora Romanelli, Marco Malagoli, Piergiorgio Zullo, Alessandro Ferri, Fabio Fiocchi, Martina Zagni, Emanuela |
author_facet | Colombo, Delia Bianchi, Luca Fabbrocini, Gabriella Corrao, Salvatore Offidani, Annamaria Stingeni, Luca Costanzo, Antonio Pellacani, Giovanni Peris, Ketty Bardazzi, Federico Argenziano, Giuseppe Ruffolo, Silvana Dapavo, Paolo Carrera, Carlo Fargnoli, Maria Concetta Parodi, Aurora Romanelli, Marco Malagoli, Piergiorgio Zullo, Alessandro Ferri, Fabio Fiocchi, Martina Zagni, Emanuela |
author_sort | Colombo, Delia |
collection | PubMed |
description | BACKGROUND: In psoriasis, several studies have indicated sex differences in clinical characteristics, type of treatment, and outcomes. A higher impact of psoriasis on quality of life (QoL) and a lower treatment satisfaction have been reported in women by different authors. OBJECTIVES: This article reports the results of a post hoc gender analysis of CANOVA study, aimed at assessing 16/24/52-week effectiveness of biologics in patients with moderate-severe plaque psoriasis. MATERIALS AND METHODS: CANOVA was a real-world, multicenter, noninterventional, retro-prospective study conducted in 17 Italian hospital dermatology clinics. RESULTS: Of the 669 eligible patients, 63.8% were men. Demographic and baseline characteristics and duration of disease were rather homogeneous between sexes. Slightly more women had been treated with biologics (50.4% vs. 46.5%) and had received ≥2 biologic treatment lines (17.2% vs. 12.4%) before study treatment. The most frequently used biologics were secukinumab, ustekinumab, adalimumab, and ixekizumab in both sexes. At 6 months, Psoriasis Area Severity Index (PASI) 75/90/100 responders were 90.8%/72.3%/45.3% of men and 89.2%/76.6%/48.2% of women. Sustained PASI responders were 79.5% of men and 75.9% of women. Treatment satisfaction was significantly lower in women at enrolment for all subscales, and was still lower at 6 months, no longer significantly. Gender distribution in Dermatology Life Quality Index total score classes showed a significantly greater effect of psoriasis on QoL in women, both at enrolment and at the 6-month follow-up. CONCLUSIONS: In conclusion, this gender analysis confirms in both genders the efficacy of biologics in psoriasis. However, women reported a greater impact of the disease on QoL and lower treatment satisfaction. |
format | Online Article Text |
id | pubmed-9148641 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Mary Ann Liebert, Inc., publishers |
record_format | MEDLINE/PubMed |
spelling | pubmed-91486412022-05-31 The CANOVA Study Real-World Evidence of Biologic Treatments in Moderate-Severe Psoriasis in Italy: A Gender Perspective Colombo, Delia Bianchi, Luca Fabbrocini, Gabriella Corrao, Salvatore Offidani, Annamaria Stingeni, Luca Costanzo, Antonio Pellacani, Giovanni Peris, Ketty Bardazzi, Federico Argenziano, Giuseppe Ruffolo, Silvana Dapavo, Paolo Carrera, Carlo Fargnoli, Maria Concetta Parodi, Aurora Romanelli, Marco Malagoli, Piergiorgio Zullo, Alessandro Ferri, Fabio Fiocchi, Martina Zagni, Emanuela Womens Health Rep (New Rochelle) Original Article BACKGROUND: In psoriasis, several studies have indicated sex differences in clinical characteristics, type of treatment, and outcomes. A higher impact of psoriasis on quality of life (QoL) and a lower treatment satisfaction have been reported in women by different authors. OBJECTIVES: This article reports the results of a post hoc gender analysis of CANOVA study, aimed at assessing 16/24/52-week effectiveness of biologics in patients with moderate-severe plaque psoriasis. MATERIALS AND METHODS: CANOVA was a real-world, multicenter, noninterventional, retro-prospective study conducted in 17 Italian hospital dermatology clinics. RESULTS: Of the 669 eligible patients, 63.8% were men. Demographic and baseline characteristics and duration of disease were rather homogeneous between sexes. Slightly more women had been treated with biologics (50.4% vs. 46.5%) and had received ≥2 biologic treatment lines (17.2% vs. 12.4%) before study treatment. The most frequently used biologics were secukinumab, ustekinumab, adalimumab, and ixekizumab in both sexes. At 6 months, Psoriasis Area Severity Index (PASI) 75/90/100 responders were 90.8%/72.3%/45.3% of men and 89.2%/76.6%/48.2% of women. Sustained PASI responders were 79.5% of men and 75.9% of women. Treatment satisfaction was significantly lower in women at enrolment for all subscales, and was still lower at 6 months, no longer significantly. Gender distribution in Dermatology Life Quality Index total score classes showed a significantly greater effect of psoriasis on QoL in women, both at enrolment and at the 6-month follow-up. CONCLUSIONS: In conclusion, this gender analysis confirms in both genders the efficacy of biologics in psoriasis. However, women reported a greater impact of the disease on QoL and lower treatment satisfaction. Mary Ann Liebert, Inc., publishers 2022-05-02 /pmc/articles/PMC9148641/ /pubmed/35651996 http://dx.doi.org/10.1089/whr.2021.0124 Text en © Delia Colombo et al., 2022; Published by Mary Ann Liebert, Inc. https://creativecommons.org/licenses/by/4.0/This Open Access article is distributed under the terms of the Creative Commons License [CC-BY] (http://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Colombo, Delia Bianchi, Luca Fabbrocini, Gabriella Corrao, Salvatore Offidani, Annamaria Stingeni, Luca Costanzo, Antonio Pellacani, Giovanni Peris, Ketty Bardazzi, Federico Argenziano, Giuseppe Ruffolo, Silvana Dapavo, Paolo Carrera, Carlo Fargnoli, Maria Concetta Parodi, Aurora Romanelli, Marco Malagoli, Piergiorgio Zullo, Alessandro Ferri, Fabio Fiocchi, Martina Zagni, Emanuela The CANOVA Study Real-World Evidence of Biologic Treatments in Moderate-Severe Psoriasis in Italy: A Gender Perspective |
title | The CANOVA Study Real-World Evidence of Biologic Treatments in Moderate-Severe Psoriasis in Italy: A Gender Perspective |
title_full | The CANOVA Study Real-World Evidence of Biologic Treatments in Moderate-Severe Psoriasis in Italy: A Gender Perspective |
title_fullStr | The CANOVA Study Real-World Evidence of Biologic Treatments in Moderate-Severe Psoriasis in Italy: A Gender Perspective |
title_full_unstemmed | The CANOVA Study Real-World Evidence of Biologic Treatments in Moderate-Severe Psoriasis in Italy: A Gender Perspective |
title_short | The CANOVA Study Real-World Evidence of Biologic Treatments in Moderate-Severe Psoriasis in Italy: A Gender Perspective |
title_sort | canova study real-world evidence of biologic treatments in moderate-severe psoriasis in italy: a gender perspective |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9148641/ https://www.ncbi.nlm.nih.gov/pubmed/35651996 http://dx.doi.org/10.1089/whr.2021.0124 |
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