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The CANOVA Study Real-World Evidence of Biologic Treatments in Moderate-Severe Psoriasis in Italy: A Gender Perspective

BACKGROUND: In psoriasis, several studies have indicated sex differences in clinical characteristics, type of treatment, and outcomes. A higher impact of psoriasis on quality of life (QoL) and a lower treatment satisfaction have been reported in women by different authors. OBJECTIVES: This article r...

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Autores principales: Colombo, Delia, Bianchi, Luca, Fabbrocini, Gabriella, Corrao, Salvatore, Offidani, Annamaria, Stingeni, Luca, Costanzo, Antonio, Pellacani, Giovanni, Peris, Ketty, Bardazzi, Federico, Argenziano, Giuseppe, Ruffolo, Silvana, Dapavo, Paolo, Carrera, Carlo, Fargnoli, Maria Concetta, Parodi, Aurora, Romanelli, Marco, Malagoli, Piergiorgio, Zullo, Alessandro, Ferri, Fabio, Fiocchi, Martina, Zagni, Emanuela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc., publishers 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9148641/
https://www.ncbi.nlm.nih.gov/pubmed/35651996
http://dx.doi.org/10.1089/whr.2021.0124
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author Colombo, Delia
Bianchi, Luca
Fabbrocini, Gabriella
Corrao, Salvatore
Offidani, Annamaria
Stingeni, Luca
Costanzo, Antonio
Pellacani, Giovanni
Peris, Ketty
Bardazzi, Federico
Argenziano, Giuseppe
Ruffolo, Silvana
Dapavo, Paolo
Carrera, Carlo
Fargnoli, Maria Concetta
Parodi, Aurora
Romanelli, Marco
Malagoli, Piergiorgio
Zullo, Alessandro
Ferri, Fabio
Fiocchi, Martina
Zagni, Emanuela
author_facet Colombo, Delia
Bianchi, Luca
Fabbrocini, Gabriella
Corrao, Salvatore
Offidani, Annamaria
Stingeni, Luca
Costanzo, Antonio
Pellacani, Giovanni
Peris, Ketty
Bardazzi, Federico
Argenziano, Giuseppe
Ruffolo, Silvana
Dapavo, Paolo
Carrera, Carlo
Fargnoli, Maria Concetta
Parodi, Aurora
Romanelli, Marco
Malagoli, Piergiorgio
Zullo, Alessandro
Ferri, Fabio
Fiocchi, Martina
Zagni, Emanuela
author_sort Colombo, Delia
collection PubMed
description BACKGROUND: In psoriasis, several studies have indicated sex differences in clinical characteristics, type of treatment, and outcomes. A higher impact of psoriasis on quality of life (QoL) and a lower treatment satisfaction have been reported in women by different authors. OBJECTIVES: This article reports the results of a post hoc gender analysis of CANOVA study, aimed at assessing 16/24/52-week effectiveness of biologics in patients with moderate-severe plaque psoriasis. MATERIALS AND METHODS: CANOVA was a real-world, multicenter, noninterventional, retro-prospective study conducted in 17 Italian hospital dermatology clinics. RESULTS: Of the 669 eligible patients, 63.8% were men. Demographic and baseline characteristics and duration of disease were rather homogeneous between sexes. Slightly more women had been treated with biologics (50.4% vs. 46.5%) and had received ≥2 biologic treatment lines (17.2% vs. 12.4%) before study treatment. The most frequently used biologics were secukinumab, ustekinumab, adalimumab, and ixekizumab in both sexes. At 6 months, Psoriasis Area Severity Index (PASI) 75/90/100 responders were 90.8%/72.3%/45.3% of men and 89.2%/76.6%/48.2% of women. Sustained PASI responders were 79.5% of men and 75.9% of women. Treatment satisfaction was significantly lower in women at enrolment for all subscales, and was still lower at 6 months, no longer significantly. Gender distribution in Dermatology Life Quality Index total score classes showed a significantly greater effect of psoriasis on QoL in women, both at enrolment and at the 6-month follow-up. CONCLUSIONS: In conclusion, this gender analysis confirms in both genders the efficacy of biologics in psoriasis. However, women reported a greater impact of the disease on QoL and lower treatment satisfaction.
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spelling pubmed-91486412022-05-31 The CANOVA Study Real-World Evidence of Biologic Treatments in Moderate-Severe Psoriasis in Italy: A Gender Perspective Colombo, Delia Bianchi, Luca Fabbrocini, Gabriella Corrao, Salvatore Offidani, Annamaria Stingeni, Luca Costanzo, Antonio Pellacani, Giovanni Peris, Ketty Bardazzi, Federico Argenziano, Giuseppe Ruffolo, Silvana Dapavo, Paolo Carrera, Carlo Fargnoli, Maria Concetta Parodi, Aurora Romanelli, Marco Malagoli, Piergiorgio Zullo, Alessandro Ferri, Fabio Fiocchi, Martina Zagni, Emanuela Womens Health Rep (New Rochelle) Original Article BACKGROUND: In psoriasis, several studies have indicated sex differences in clinical characteristics, type of treatment, and outcomes. A higher impact of psoriasis on quality of life (QoL) and a lower treatment satisfaction have been reported in women by different authors. OBJECTIVES: This article reports the results of a post hoc gender analysis of CANOVA study, aimed at assessing 16/24/52-week effectiveness of biologics in patients with moderate-severe plaque psoriasis. MATERIALS AND METHODS: CANOVA was a real-world, multicenter, noninterventional, retro-prospective study conducted in 17 Italian hospital dermatology clinics. RESULTS: Of the 669 eligible patients, 63.8% were men. Demographic and baseline characteristics and duration of disease were rather homogeneous between sexes. Slightly more women had been treated with biologics (50.4% vs. 46.5%) and had received ≥2 biologic treatment lines (17.2% vs. 12.4%) before study treatment. The most frequently used biologics were secukinumab, ustekinumab, adalimumab, and ixekizumab in both sexes. At 6 months, Psoriasis Area Severity Index (PASI) 75/90/100 responders were 90.8%/72.3%/45.3% of men and 89.2%/76.6%/48.2% of women. Sustained PASI responders were 79.5% of men and 75.9% of women. Treatment satisfaction was significantly lower in women at enrolment for all subscales, and was still lower at 6 months, no longer significantly. Gender distribution in Dermatology Life Quality Index total score classes showed a significantly greater effect of psoriasis on QoL in women, both at enrolment and at the 6-month follow-up. CONCLUSIONS: In conclusion, this gender analysis confirms in both genders the efficacy of biologics in psoriasis. However, women reported a greater impact of the disease on QoL and lower treatment satisfaction. Mary Ann Liebert, Inc., publishers 2022-05-02 /pmc/articles/PMC9148641/ /pubmed/35651996 http://dx.doi.org/10.1089/whr.2021.0124 Text en © Delia Colombo et al., 2022; Published by Mary Ann Liebert, Inc. https://creativecommons.org/licenses/by/4.0/This Open Access article is distributed under the terms of the Creative Commons License [CC-BY] (http://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Colombo, Delia
Bianchi, Luca
Fabbrocini, Gabriella
Corrao, Salvatore
Offidani, Annamaria
Stingeni, Luca
Costanzo, Antonio
Pellacani, Giovanni
Peris, Ketty
Bardazzi, Federico
Argenziano, Giuseppe
Ruffolo, Silvana
Dapavo, Paolo
Carrera, Carlo
Fargnoli, Maria Concetta
Parodi, Aurora
Romanelli, Marco
Malagoli, Piergiorgio
Zullo, Alessandro
Ferri, Fabio
Fiocchi, Martina
Zagni, Emanuela
The CANOVA Study Real-World Evidence of Biologic Treatments in Moderate-Severe Psoriasis in Italy: A Gender Perspective
title The CANOVA Study Real-World Evidence of Biologic Treatments in Moderate-Severe Psoriasis in Italy: A Gender Perspective
title_full The CANOVA Study Real-World Evidence of Biologic Treatments in Moderate-Severe Psoriasis in Italy: A Gender Perspective
title_fullStr The CANOVA Study Real-World Evidence of Biologic Treatments in Moderate-Severe Psoriasis in Italy: A Gender Perspective
title_full_unstemmed The CANOVA Study Real-World Evidence of Biologic Treatments in Moderate-Severe Psoriasis in Italy: A Gender Perspective
title_short The CANOVA Study Real-World Evidence of Biologic Treatments in Moderate-Severe Psoriasis in Italy: A Gender Perspective
title_sort canova study real-world evidence of biologic treatments in moderate-severe psoriasis in italy: a gender perspective
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9148641/
https://www.ncbi.nlm.nih.gov/pubmed/35651996
http://dx.doi.org/10.1089/whr.2021.0124
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