The Promise of Single-cell Technology in Providing New Insights Into the Molecular Heterogeneity and Management of Acute Lymphoblastic Leukemia

Drug resistance and treatment failure in pediatric acute lymphoblastic leukemia (ALL) are in part driven by tumor heterogeneity and clonal evolution. Although bulk tumor genomic analyses have provided some insight into these processes, single-cell sequencing has emerged as a powerful technique to pr...

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Detalles Bibliográficos
Autores principales: Pearson, Holly C.L., Hunt, Kooper V., Trahair, Toby N., Lock, Richard B., Lee, Heather J., de Bock, Charles E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9148686/
https://www.ncbi.nlm.nih.gov/pubmed/35651714
http://dx.doi.org/10.1097/HS9.0000000000000734

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