In Vivo Generation of Organs by Blastocyst Complementation: Advances and Challenges

The ultimate goal of regenerative medicine is to replace damaged cells, tissues or whole organs, in order to restore their proper function. Stem cell related technologies promise to generate transplants from the patients’ own cells. Novel approaches such as blastocyst complementation combined with g...

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Detalles Bibliográficos
Autores principales: Founta, Konstantina-Maria, Papanayotou, Costis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Stem Cell Research 2021
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9148837/
https://www.ncbi.nlm.nih.gov/pubmed/34711704
http://dx.doi.org/10.15283/ijsc21122
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author Founta, Konstantina-Maria
Papanayotou, Costis
author_facet Founta, Konstantina-Maria
Papanayotou, Costis
author_sort Founta, Konstantina-Maria
collection PubMed
description The ultimate goal of regenerative medicine is to replace damaged cells, tissues or whole organs, in order to restore their proper function. Stem cell related technologies promise to generate transplants from the patients’ own cells. Novel approaches such as blastocyst complementation combined with genome editing techniques open up new perspectives for organ replacement therapies. This review summarizes recent advances in the field and highlights the challenges that still remain to be addressed.
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spelling pubmed-91488372022-06-01 In Vivo Generation of Organs by Blastocyst Complementation: Advances and Challenges Founta, Konstantina-Maria Papanayotou, Costis Int J Stem Cells Review Article The ultimate goal of regenerative medicine is to replace damaged cells, tissues or whole organs, in order to restore their proper function. Stem cell related technologies promise to generate transplants from the patients’ own cells. Novel approaches such as blastocyst complementation combined with genome editing techniques open up new perspectives for organ replacement therapies. This review summarizes recent advances in the field and highlights the challenges that still remain to be addressed. Korean Society for Stem Cell Research 2021-10-31 /pmc/articles/PMC9148837/ /pubmed/34711704 http://dx.doi.org/10.15283/ijsc21122 Text en Copyright © 2022 by the Korean Society for Stem Cell Research https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Founta, Konstantina-Maria
Papanayotou, Costis
In Vivo Generation of Organs by Blastocyst Complementation: Advances and Challenges
title In Vivo Generation of Organs by Blastocyst Complementation: Advances and Challenges
title_full In Vivo Generation of Organs by Blastocyst Complementation: Advances and Challenges
title_fullStr In Vivo Generation of Organs by Blastocyst Complementation: Advances and Challenges
title_full_unstemmed In Vivo Generation of Organs by Blastocyst Complementation: Advances and Challenges
title_short In Vivo Generation of Organs by Blastocyst Complementation: Advances and Challenges
title_sort in vivo generation of organs by blastocyst complementation: advances and challenges
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9148837/
https://www.ncbi.nlm.nih.gov/pubmed/34711704
http://dx.doi.org/10.15283/ijsc21122
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