The Role of Feedback Loops in Targeted Therapy for Pancreatic Cancer

Pancreatic cancer is the leading cause of cancer-related deaths worldwide, with limited treatment options and low long-term survival rates. The complex and variable signal regulation networks are one of the important reasons why it is difficult for pancreatic cancer to develop precise targeted thera...

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Detalles Bibliográficos
Autores principales: Gu, Weigang, Shen, HongZhang, Xie, Lu, Zhang, Xiaofeng, Yang, Jianfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9148955/
https://www.ncbi.nlm.nih.gov/pubmed/35651786
http://dx.doi.org/10.3389/fonc.2022.800140
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author Gu, Weigang
Shen, HongZhang
Xie, Lu
Zhang, Xiaofeng
Yang, Jianfeng
author_facet Gu, Weigang
Shen, HongZhang
Xie, Lu
Zhang, Xiaofeng
Yang, Jianfeng
author_sort Gu, Weigang
collection PubMed
description Pancreatic cancer is the leading cause of cancer-related deaths worldwide, with limited treatment options and low long-term survival rates. The complex and variable signal regulation networks are one of the important reasons why it is difficult for pancreatic cancer to develop precise targeted therapy drugs. Numerous studies have associated feedback loop regulation with the development and therapeutic response of cancers including pancreatic cancer. Therefore, we review researches on the role of feedback loops in the progression of pancreatic cancer, and summarize the connection between feedback loops and several signaling pathways in pancreatic cancer, as well as recent advances in the intervention of feedback loops in pancreatic cancer treatment, highlighting the potential of capitalizing on feedback loops modulation in targeted therapy for pancreatic cancer.
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spelling pubmed-91489552022-05-31 The Role of Feedback Loops in Targeted Therapy for Pancreatic Cancer Gu, Weigang Shen, HongZhang Xie, Lu Zhang, Xiaofeng Yang, Jianfeng Front Oncol Oncology Pancreatic cancer is the leading cause of cancer-related deaths worldwide, with limited treatment options and low long-term survival rates. The complex and variable signal regulation networks are one of the important reasons why it is difficult for pancreatic cancer to develop precise targeted therapy drugs. Numerous studies have associated feedback loop regulation with the development and therapeutic response of cancers including pancreatic cancer. Therefore, we review researches on the role of feedback loops in the progression of pancreatic cancer, and summarize the connection between feedback loops and several signaling pathways in pancreatic cancer, as well as recent advances in the intervention of feedback loops in pancreatic cancer treatment, highlighting the potential of capitalizing on feedback loops modulation in targeted therapy for pancreatic cancer. Frontiers Media S.A. 2022-05-16 /pmc/articles/PMC9148955/ /pubmed/35651786 http://dx.doi.org/10.3389/fonc.2022.800140 Text en Copyright © 2022 Gu, Shen, Xie, Zhang and Yang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Gu, Weigang
Shen, HongZhang
Xie, Lu
Zhang, Xiaofeng
Yang, Jianfeng
The Role of Feedback Loops in Targeted Therapy for Pancreatic Cancer
title The Role of Feedback Loops in Targeted Therapy for Pancreatic Cancer
title_full The Role of Feedback Loops in Targeted Therapy for Pancreatic Cancer
title_fullStr The Role of Feedback Loops in Targeted Therapy for Pancreatic Cancer
title_full_unstemmed The Role of Feedback Loops in Targeted Therapy for Pancreatic Cancer
title_short The Role of Feedback Loops in Targeted Therapy for Pancreatic Cancer
title_sort role of feedback loops in targeted therapy for pancreatic cancer
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9148955/
https://www.ncbi.nlm.nih.gov/pubmed/35651786
http://dx.doi.org/10.3389/fonc.2022.800140
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