Survival of HT29 Cancer Cells Is Affected by IGF1R Inhibition via Modulation of Self-DNA-Triggered TLR9 Signaling and the Autophagy Response

Purpose: In HT29 colon cancer cells, a close interplay between self-DNA-induced TLR9 signaling and autophagy response was found, with remarkable effects on cell survival and differentiation. IGF1R activation drives the development and malignant progression of colorectal cancer. IGF1R inhibition disp...

Descripción completa

Detalles Bibliográficos
Autores principales: Sipos, Ferenc, Bohusné Barta, Bettina, Simon, Ágnes, Nagy, Lőrinc, Dankó, Titanilla, Raffay, Regina Eszter, Petővári, Gábor, Zsiros, Viktória, Wichmann, Barnabás, Sebestyén, Anna, Műzes, Györgyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pathology and Oncology Archive
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9148969/
https://www.ncbi.nlm.nih.gov/pubmed/35651701
http://dx.doi.org/10.3389/pore.2022.1610322

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9148969/
https://www.ncbi.nlm.nih.gov/pubmed/35651701
http://dx.doi.org/10.3389/pore.2022.1610322

Ejemplares similares