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Troubleshooting Gait Disturbances in Parkinson’s Disease With Deep Brain Stimulation
Deep brain stimulation (DBS) of the subthalamic nucleus or the globus pallidus is an established treatment for Parkinson’s disease (PD) that yields a marked and lasting improvement of motor symptoms. Yet, DBS benefit on gait disturbances in PD is still debated and can be a source of dissatisfaction...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9148971/ https://www.ncbi.nlm.nih.gov/pubmed/35652005 http://dx.doi.org/10.3389/fnhum.2022.806513 |
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author | Pozzi, Nicoló G. Palmisano, Chiara Reich, Martin M. Capetian, Philip Pacchetti, Claudio Volkmann, Jens Isaias, Ioannis U. |
author_facet | Pozzi, Nicoló G. Palmisano, Chiara Reich, Martin M. Capetian, Philip Pacchetti, Claudio Volkmann, Jens Isaias, Ioannis U. |
author_sort | Pozzi, Nicoló G. |
collection | PubMed |
description | Deep brain stimulation (DBS) of the subthalamic nucleus or the globus pallidus is an established treatment for Parkinson’s disease (PD) that yields a marked and lasting improvement of motor symptoms. Yet, DBS benefit on gait disturbances in PD is still debated and can be a source of dissatisfaction and poor quality of life. Gait disturbances in PD encompass a variety of clinical manifestations and rely on different pathophysiological bases. While gait disturbances arising years after DBS surgery can be related to disease progression, early impairment of gait may be secondary to treatable causes and benefits from DBS reprogramming. In this review, we tackle the issue of gait disturbances in PD patients with DBS by discussing their neurophysiological basis, providing a detailed clinical characterization, and proposing a pragmatic programming approach to support their management. |
format | Online Article Text |
id | pubmed-9148971 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-91489712022-05-31 Troubleshooting Gait Disturbances in Parkinson’s Disease With Deep Brain Stimulation Pozzi, Nicoló G. Palmisano, Chiara Reich, Martin M. Capetian, Philip Pacchetti, Claudio Volkmann, Jens Isaias, Ioannis U. Front Hum Neurosci Human Neuroscience Deep brain stimulation (DBS) of the subthalamic nucleus or the globus pallidus is an established treatment for Parkinson’s disease (PD) that yields a marked and lasting improvement of motor symptoms. Yet, DBS benefit on gait disturbances in PD is still debated and can be a source of dissatisfaction and poor quality of life. Gait disturbances in PD encompass a variety of clinical manifestations and rely on different pathophysiological bases. While gait disturbances arising years after DBS surgery can be related to disease progression, early impairment of gait may be secondary to treatable causes and benefits from DBS reprogramming. In this review, we tackle the issue of gait disturbances in PD patients with DBS by discussing their neurophysiological basis, providing a detailed clinical characterization, and proposing a pragmatic programming approach to support their management. Frontiers Media S.A. 2022-05-16 /pmc/articles/PMC9148971/ /pubmed/35652005 http://dx.doi.org/10.3389/fnhum.2022.806513 Text en Copyright © 2022 Pozzi, Palmisano, Reich, Capetian, Pacchetti, Volkmann and Isaias. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Human Neuroscience Pozzi, Nicoló G. Palmisano, Chiara Reich, Martin M. Capetian, Philip Pacchetti, Claudio Volkmann, Jens Isaias, Ioannis U. Troubleshooting Gait Disturbances in Parkinson’s Disease With Deep Brain Stimulation |
title | Troubleshooting Gait Disturbances in Parkinson’s Disease With Deep Brain Stimulation |
title_full | Troubleshooting Gait Disturbances in Parkinson’s Disease With Deep Brain Stimulation |
title_fullStr | Troubleshooting Gait Disturbances in Parkinson’s Disease With Deep Brain Stimulation |
title_full_unstemmed | Troubleshooting Gait Disturbances in Parkinson’s Disease With Deep Brain Stimulation |
title_short | Troubleshooting Gait Disturbances in Parkinson’s Disease With Deep Brain Stimulation |
title_sort | troubleshooting gait disturbances in parkinson’s disease with deep brain stimulation |
topic | Human Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9148971/ https://www.ncbi.nlm.nih.gov/pubmed/35652005 http://dx.doi.org/10.3389/fnhum.2022.806513 |
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