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Troubleshooting Gait Disturbances in Parkinson’s Disease With Deep Brain Stimulation

Deep brain stimulation (DBS) of the subthalamic nucleus or the globus pallidus is an established treatment for Parkinson’s disease (PD) that yields a marked and lasting improvement of motor symptoms. Yet, DBS benefit on gait disturbances in PD is still debated and can be a source of dissatisfaction...

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Autores principales: Pozzi, Nicoló G., Palmisano, Chiara, Reich, Martin M., Capetian, Philip, Pacchetti, Claudio, Volkmann, Jens, Isaias, Ioannis U.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9148971/
https://www.ncbi.nlm.nih.gov/pubmed/35652005
http://dx.doi.org/10.3389/fnhum.2022.806513
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author Pozzi, Nicoló G.
Palmisano, Chiara
Reich, Martin M.
Capetian, Philip
Pacchetti, Claudio
Volkmann, Jens
Isaias, Ioannis U.
author_facet Pozzi, Nicoló G.
Palmisano, Chiara
Reich, Martin M.
Capetian, Philip
Pacchetti, Claudio
Volkmann, Jens
Isaias, Ioannis U.
author_sort Pozzi, Nicoló G.
collection PubMed
description Deep brain stimulation (DBS) of the subthalamic nucleus or the globus pallidus is an established treatment for Parkinson’s disease (PD) that yields a marked and lasting improvement of motor symptoms. Yet, DBS benefit on gait disturbances in PD is still debated and can be a source of dissatisfaction and poor quality of life. Gait disturbances in PD encompass a variety of clinical manifestations and rely on different pathophysiological bases. While gait disturbances arising years after DBS surgery can be related to disease progression, early impairment of gait may be secondary to treatable causes and benefits from DBS reprogramming. In this review, we tackle the issue of gait disturbances in PD patients with DBS by discussing their neurophysiological basis, providing a detailed clinical characterization, and proposing a pragmatic programming approach to support their management.
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spelling pubmed-91489712022-05-31 Troubleshooting Gait Disturbances in Parkinson’s Disease With Deep Brain Stimulation Pozzi, Nicoló G. Palmisano, Chiara Reich, Martin M. Capetian, Philip Pacchetti, Claudio Volkmann, Jens Isaias, Ioannis U. Front Hum Neurosci Human Neuroscience Deep brain stimulation (DBS) of the subthalamic nucleus or the globus pallidus is an established treatment for Parkinson’s disease (PD) that yields a marked and lasting improvement of motor symptoms. Yet, DBS benefit on gait disturbances in PD is still debated and can be a source of dissatisfaction and poor quality of life. Gait disturbances in PD encompass a variety of clinical manifestations and rely on different pathophysiological bases. While gait disturbances arising years after DBS surgery can be related to disease progression, early impairment of gait may be secondary to treatable causes and benefits from DBS reprogramming. In this review, we tackle the issue of gait disturbances in PD patients with DBS by discussing their neurophysiological basis, providing a detailed clinical characterization, and proposing a pragmatic programming approach to support their management. Frontiers Media S.A. 2022-05-16 /pmc/articles/PMC9148971/ /pubmed/35652005 http://dx.doi.org/10.3389/fnhum.2022.806513 Text en Copyright © 2022 Pozzi, Palmisano, Reich, Capetian, Pacchetti, Volkmann and Isaias. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Human Neuroscience
Pozzi, Nicoló G.
Palmisano, Chiara
Reich, Martin M.
Capetian, Philip
Pacchetti, Claudio
Volkmann, Jens
Isaias, Ioannis U.
Troubleshooting Gait Disturbances in Parkinson’s Disease With Deep Brain Stimulation
title Troubleshooting Gait Disturbances in Parkinson’s Disease With Deep Brain Stimulation
title_full Troubleshooting Gait Disturbances in Parkinson’s Disease With Deep Brain Stimulation
title_fullStr Troubleshooting Gait Disturbances in Parkinson’s Disease With Deep Brain Stimulation
title_full_unstemmed Troubleshooting Gait Disturbances in Parkinson’s Disease With Deep Brain Stimulation
title_short Troubleshooting Gait Disturbances in Parkinson’s Disease With Deep Brain Stimulation
title_sort troubleshooting gait disturbances in parkinson’s disease with deep brain stimulation
topic Human Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9148971/
https://www.ncbi.nlm.nih.gov/pubmed/35652005
http://dx.doi.org/10.3389/fnhum.2022.806513
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