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Decreased Efficiency of Between-Network Dynamics During Early Memory Consolidation With Aging

Aging is associated with memory decline and progressive disabilities in the activities of daily living. These deficits have a significant impact on the quality of life of the aging population and lead to a tremendous burden on societies and health care systems. Understanding the mechanisms underlyin...

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Autores principales: Faßbender, Ronja V., Risius, Okka J., Dronse, Julian, Richter, Nils, Gramespacher, Hannes, Befahr, Qumars, Fink, Gereon R., Kukolja, Juraj, Onur, Oezguer A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9148994/
https://www.ncbi.nlm.nih.gov/pubmed/35651531
http://dx.doi.org/10.3389/fnagi.2022.780630
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author Faßbender, Ronja V.
Risius, Okka J.
Dronse, Julian
Richter, Nils
Gramespacher, Hannes
Befahr, Qumars
Fink, Gereon R.
Kukolja, Juraj
Onur, Oezguer A.
author_facet Faßbender, Ronja V.
Risius, Okka J.
Dronse, Julian
Richter, Nils
Gramespacher, Hannes
Befahr, Qumars
Fink, Gereon R.
Kukolja, Juraj
Onur, Oezguer A.
author_sort Faßbender, Ronja V.
collection PubMed
description Aging is associated with memory decline and progressive disabilities in the activities of daily living. These deficits have a significant impact on the quality of life of the aging population and lead to a tremendous burden on societies and health care systems. Understanding the mechanisms underlying aging-related memory decline is likely to inform the development of compensatory strategies promoting independence in old age. Research on aging-related memory decline has mainly focused on encoding and retrieval. However, some findings suggest that memory deficits may at least partly be due to impaired consolidation. To date, it remains elusive whether aging-related memory decline results from defective consolidation. This study examined age effects on consolidation-related neural mechanisms and their susceptibility to interference using functional magnetic resonance imaging data from 13 younger (20–30 years, 8 female) and 16 older (49–75 years, 5 female) healthy participants. fMRI was performed before and during a memory paradigm comprised of encoding, consolidation, and retrieval phases. Consolidation was variously challenged: (1) control (no manipulation), (2) interference (repeated stimulus presentation with interfering information), and (3) reminder condition (repeated presentation without interfering information). We analyzed the fractional amplitude of low-frequency fluctuations (fALFF) to compare brain activity changes from pre- to post-encoding rest. In the control condition, fALFF was decreased in the left supramarginal gyrus, right middle temporal gyrus, and left precuneus but increased in parts of the occipital and inferior temporal cortex. Connectivity analyses between fALFF-derived seeds and network ROIs revealed an aging-related decrease in the efficiency of functional connectivity (FC) within the ventral stream network and between salience, default mode, and central executive networks during consolidation. Moreover, our results indicate increased interference susceptibility in older individuals with dynamics between salience and default mode networks as a neurophysiological correlate. Conclusively, aging-related memory decline is partly caused by inefficient consolidation. Memory consolidation requires a complex interplay between large-scale brain networks, which qualitatively decreases with age.
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spelling pubmed-91489942022-05-31 Decreased Efficiency of Between-Network Dynamics During Early Memory Consolidation With Aging Faßbender, Ronja V. Risius, Okka J. Dronse, Julian Richter, Nils Gramespacher, Hannes Befahr, Qumars Fink, Gereon R. Kukolja, Juraj Onur, Oezguer A. Front Aging Neurosci Neuroscience Aging is associated with memory decline and progressive disabilities in the activities of daily living. These deficits have a significant impact on the quality of life of the aging population and lead to a tremendous burden on societies and health care systems. Understanding the mechanisms underlying aging-related memory decline is likely to inform the development of compensatory strategies promoting independence in old age. Research on aging-related memory decline has mainly focused on encoding and retrieval. However, some findings suggest that memory deficits may at least partly be due to impaired consolidation. To date, it remains elusive whether aging-related memory decline results from defective consolidation. This study examined age effects on consolidation-related neural mechanisms and their susceptibility to interference using functional magnetic resonance imaging data from 13 younger (20–30 years, 8 female) and 16 older (49–75 years, 5 female) healthy participants. fMRI was performed before and during a memory paradigm comprised of encoding, consolidation, and retrieval phases. Consolidation was variously challenged: (1) control (no manipulation), (2) interference (repeated stimulus presentation with interfering information), and (3) reminder condition (repeated presentation without interfering information). We analyzed the fractional amplitude of low-frequency fluctuations (fALFF) to compare brain activity changes from pre- to post-encoding rest. In the control condition, fALFF was decreased in the left supramarginal gyrus, right middle temporal gyrus, and left precuneus but increased in parts of the occipital and inferior temporal cortex. Connectivity analyses between fALFF-derived seeds and network ROIs revealed an aging-related decrease in the efficiency of functional connectivity (FC) within the ventral stream network and between salience, default mode, and central executive networks during consolidation. Moreover, our results indicate increased interference susceptibility in older individuals with dynamics between salience and default mode networks as a neurophysiological correlate. Conclusively, aging-related memory decline is partly caused by inefficient consolidation. Memory consolidation requires a complex interplay between large-scale brain networks, which qualitatively decreases with age. Frontiers Media S.A. 2022-05-16 /pmc/articles/PMC9148994/ /pubmed/35651531 http://dx.doi.org/10.3389/fnagi.2022.780630 Text en Copyright © 2022 Faßbender, Risius, Dronse, Richter, Gramespacher, Befahr, Fink, Kukolja and Onur. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Faßbender, Ronja V.
Risius, Okka J.
Dronse, Julian
Richter, Nils
Gramespacher, Hannes
Befahr, Qumars
Fink, Gereon R.
Kukolja, Juraj
Onur, Oezguer A.
Decreased Efficiency of Between-Network Dynamics During Early Memory Consolidation With Aging
title Decreased Efficiency of Between-Network Dynamics During Early Memory Consolidation With Aging
title_full Decreased Efficiency of Between-Network Dynamics During Early Memory Consolidation With Aging
title_fullStr Decreased Efficiency of Between-Network Dynamics During Early Memory Consolidation With Aging
title_full_unstemmed Decreased Efficiency of Between-Network Dynamics During Early Memory Consolidation With Aging
title_short Decreased Efficiency of Between-Network Dynamics During Early Memory Consolidation With Aging
title_sort decreased efficiency of between-network dynamics during early memory consolidation with aging
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9148994/
https://www.ncbi.nlm.nih.gov/pubmed/35651531
http://dx.doi.org/10.3389/fnagi.2022.780630
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