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Molecular Determinants Regulating the Plasticity of the MHC Class II Immunopeptidome
In the last few years, advancement in the analysis of the MHC class II (MHC-II) ligandome in several mouse and human haplotypes has increased our understanding of the molecular components that regulate the range and selection of the MHC-II presented peptides, from MHC class II molecule polymorphisms...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9148998/ https://www.ncbi.nlm.nih.gov/pubmed/35651601 http://dx.doi.org/10.3389/fimmu.2022.878271 |
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author | Santambrogio, Laura |
author_facet | Santambrogio, Laura |
author_sort | Santambrogio, Laura |
collection | PubMed |
description | In the last few years, advancement in the analysis of the MHC class II (MHC-II) ligandome in several mouse and human haplotypes has increased our understanding of the molecular components that regulate the range and selection of the MHC-II presented peptides, from MHC class II molecule polymorphisms to the recognition of different conformers, functional differences in endosomal processing along the endocytic tract, and the interplay between the MHC class II chaperones DM and DO. The sum of all these variables contributes, qualitatively and quantitatively, to the composition of the MHC II ligandome, altogether ensuring that the immunopeptidome landscape is highly sensitive to any changes in the composition of the intra- and extracellular proteome for a comprehensive survey of the microenvironment for MHC II presentation to CD4 T cells. |
format | Online Article Text |
id | pubmed-9148998 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-91489982022-05-31 Molecular Determinants Regulating the Plasticity of the MHC Class II Immunopeptidome Santambrogio, Laura Front Immunol Immunology In the last few years, advancement in the analysis of the MHC class II (MHC-II) ligandome in several mouse and human haplotypes has increased our understanding of the molecular components that regulate the range and selection of the MHC-II presented peptides, from MHC class II molecule polymorphisms to the recognition of different conformers, functional differences in endosomal processing along the endocytic tract, and the interplay between the MHC class II chaperones DM and DO. The sum of all these variables contributes, qualitatively and quantitatively, to the composition of the MHC II ligandome, altogether ensuring that the immunopeptidome landscape is highly sensitive to any changes in the composition of the intra- and extracellular proteome for a comprehensive survey of the microenvironment for MHC II presentation to CD4 T cells. Frontiers Media S.A. 2022-05-16 /pmc/articles/PMC9148998/ /pubmed/35651601 http://dx.doi.org/10.3389/fimmu.2022.878271 Text en Copyright © 2022 Santambrogio https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Santambrogio, Laura Molecular Determinants Regulating the Plasticity of the MHC Class II Immunopeptidome |
title | Molecular Determinants Regulating the Plasticity of the MHC Class II Immunopeptidome |
title_full | Molecular Determinants Regulating the Plasticity of the MHC Class II Immunopeptidome |
title_fullStr | Molecular Determinants Regulating the Plasticity of the MHC Class II Immunopeptidome |
title_full_unstemmed | Molecular Determinants Regulating the Plasticity of the MHC Class II Immunopeptidome |
title_short | Molecular Determinants Regulating the Plasticity of the MHC Class II Immunopeptidome |
title_sort | molecular determinants regulating the plasticity of the mhc class ii immunopeptidome |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9148998/ https://www.ncbi.nlm.nih.gov/pubmed/35651601 http://dx.doi.org/10.3389/fimmu.2022.878271 |
work_keys_str_mv | AT santambrogiolaura moleculardeterminantsregulatingtheplasticityofthemhcclassiiimmunopeptidome |