Cargando…

Molecular Determinants Regulating the Plasticity of the MHC Class II Immunopeptidome

In the last few years, advancement in the analysis of the MHC class II (MHC-II) ligandome in several mouse and human haplotypes has increased our understanding of the molecular components that regulate the range and selection of the MHC-II presented peptides, from MHC class II molecule polymorphisms...

Descripción completa

Detalles Bibliográficos
Autor principal: Santambrogio, Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9148998/
https://www.ncbi.nlm.nih.gov/pubmed/35651601
http://dx.doi.org/10.3389/fimmu.2022.878271
_version_ 1784717126221692928
author Santambrogio, Laura
author_facet Santambrogio, Laura
author_sort Santambrogio, Laura
collection PubMed
description In the last few years, advancement in the analysis of the MHC class II (MHC-II) ligandome in several mouse and human haplotypes has increased our understanding of the molecular components that regulate the range and selection of the MHC-II presented peptides, from MHC class II molecule polymorphisms to the recognition of different conformers, functional differences in endosomal processing along the endocytic tract, and the interplay between the MHC class II chaperones DM and DO. The sum of all these variables contributes, qualitatively and quantitatively, to the composition of the MHC II ligandome, altogether ensuring that the immunopeptidome landscape is highly sensitive to any changes in the composition of the intra- and extracellular proteome for a comprehensive survey of the microenvironment for MHC II presentation to CD4 T cells.
format Online
Article
Text
id pubmed-9148998
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-91489982022-05-31 Molecular Determinants Regulating the Plasticity of the MHC Class II Immunopeptidome Santambrogio, Laura Front Immunol Immunology In the last few years, advancement in the analysis of the MHC class II (MHC-II) ligandome in several mouse and human haplotypes has increased our understanding of the molecular components that regulate the range and selection of the MHC-II presented peptides, from MHC class II molecule polymorphisms to the recognition of different conformers, functional differences in endosomal processing along the endocytic tract, and the interplay between the MHC class II chaperones DM and DO. The sum of all these variables contributes, qualitatively and quantitatively, to the composition of the MHC II ligandome, altogether ensuring that the immunopeptidome landscape is highly sensitive to any changes in the composition of the intra- and extracellular proteome for a comprehensive survey of the microenvironment for MHC II presentation to CD4 T cells. Frontiers Media S.A. 2022-05-16 /pmc/articles/PMC9148998/ /pubmed/35651601 http://dx.doi.org/10.3389/fimmu.2022.878271 Text en Copyright © 2022 Santambrogio https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Santambrogio, Laura
Molecular Determinants Regulating the Plasticity of the MHC Class II Immunopeptidome
title Molecular Determinants Regulating the Plasticity of the MHC Class II Immunopeptidome
title_full Molecular Determinants Regulating the Plasticity of the MHC Class II Immunopeptidome
title_fullStr Molecular Determinants Regulating the Plasticity of the MHC Class II Immunopeptidome
title_full_unstemmed Molecular Determinants Regulating the Plasticity of the MHC Class II Immunopeptidome
title_short Molecular Determinants Regulating the Plasticity of the MHC Class II Immunopeptidome
title_sort molecular determinants regulating the plasticity of the mhc class ii immunopeptidome
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9148998/
https://www.ncbi.nlm.nih.gov/pubmed/35651601
http://dx.doi.org/10.3389/fimmu.2022.878271
work_keys_str_mv AT santambrogiolaura moleculardeterminantsregulatingtheplasticityofthemhcclassiiimmunopeptidome