Role of Selective Histone Deacetylase 6 Inhibitor ACY-1215 in Cancer and Other Human Diseases

The deacetylation process regulated by histone deacetylases (HDACs) plays an important role in human health and diseases. HDAC6 belongs to the Class IIb of HDACs family, which mainly modifies non-histone proteins located in the cytoplasm. HDAC6 plays a key role in tumors, neurological diseases, and...

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Autores principales: Li, Jianglei, Yu, Meihong, Fu, Shifeng, Liu, Deliang, Tan, Yuyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9149003/
https://www.ncbi.nlm.nih.gov/pubmed/35652048
http://dx.doi.org/10.3389/fphar.2022.907981
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author Li, Jianglei
Yu, Meihong
Fu, Shifeng
Liu, Deliang
Tan, Yuyong
author_facet Li, Jianglei
Yu, Meihong
Fu, Shifeng
Liu, Deliang
Tan, Yuyong
author_sort Li, Jianglei
collection PubMed
description The deacetylation process regulated by histone deacetylases (HDACs) plays an important role in human health and diseases. HDAC6 belongs to the Class IIb of HDACs family, which mainly modifies non-histone proteins located in the cytoplasm. HDAC6 plays a key role in tumors, neurological diseases, and inflammatory diseases. Therefore, targeting HDAC6 has become a promising treatment strategy in recent years. ACY-1215 is the first orally available highly selective HDAC6 inhibitor, and its efficacy and therapeutic effects are being continuously verified. This review summarizes the research progress of ACY-1215 in cancer and other human diseases, as well as the underlying mechanism, in order to guide the future clinical trials of ACY-1215 and more in-depth mechanism researches.
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spelling pubmed-91490032022-05-31 Role of Selective Histone Deacetylase 6 Inhibitor ACY-1215 in Cancer and Other Human Diseases Li, Jianglei Yu, Meihong Fu, Shifeng Liu, Deliang Tan, Yuyong Front Pharmacol Pharmacology The deacetylation process regulated by histone deacetylases (HDACs) plays an important role in human health and diseases. HDAC6 belongs to the Class IIb of HDACs family, which mainly modifies non-histone proteins located in the cytoplasm. HDAC6 plays a key role in tumors, neurological diseases, and inflammatory diseases. Therefore, targeting HDAC6 has become a promising treatment strategy in recent years. ACY-1215 is the first orally available highly selective HDAC6 inhibitor, and its efficacy and therapeutic effects are being continuously verified. This review summarizes the research progress of ACY-1215 in cancer and other human diseases, as well as the underlying mechanism, in order to guide the future clinical trials of ACY-1215 and more in-depth mechanism researches. Frontiers Media S.A. 2022-05-16 /pmc/articles/PMC9149003/ /pubmed/35652048 http://dx.doi.org/10.3389/fphar.2022.907981 Text en Copyright © 2022 Li, Yu, Fu, Liu and Tan. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Li, Jianglei
Yu, Meihong
Fu, Shifeng
Liu, Deliang
Tan, Yuyong
Role of Selective Histone Deacetylase 6 Inhibitor ACY-1215 in Cancer and Other Human Diseases
title Role of Selective Histone Deacetylase 6 Inhibitor ACY-1215 in Cancer and Other Human Diseases
title_full Role of Selective Histone Deacetylase 6 Inhibitor ACY-1215 in Cancer and Other Human Diseases
title_fullStr Role of Selective Histone Deacetylase 6 Inhibitor ACY-1215 in Cancer and Other Human Diseases
title_full_unstemmed Role of Selective Histone Deacetylase 6 Inhibitor ACY-1215 in Cancer and Other Human Diseases
title_short Role of Selective Histone Deacetylase 6 Inhibitor ACY-1215 in Cancer and Other Human Diseases
title_sort role of selective histone deacetylase 6 inhibitor acy-1215 in cancer and other human diseases
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9149003/
https://www.ncbi.nlm.nih.gov/pubmed/35652048
http://dx.doi.org/10.3389/fphar.2022.907981
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