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A wolf in sheep's clothing: Dogs confer an unrecognized risk for their immunocompromised master

Bordetella bronchiseptica is a pleomorphic gram-negative coccobacillus that commonly causes respiratory tract infections in canines, felines, and swine. Human infections are rare. We report a case of Bordetella bronchiseptica pneumonia in a 67-year-old immunocompromised host. His past medical histor...

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Autores principales: Agarwal, Lipisha, Singh, Harpreet, Jani, Chinmay, Banankhah, Peymaan, Abdalla, Mohammed, Kurman, Jonathan S., Franco, Rose A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9149181/
https://www.ncbi.nlm.nih.gov/pubmed/35651518
http://dx.doi.org/10.1016/j.rmcr.2022.101672
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author Agarwal, Lipisha
Singh, Harpreet
Jani, Chinmay
Banankhah, Peymaan
Abdalla, Mohammed
Kurman, Jonathan S.
Franco, Rose A.
author_facet Agarwal, Lipisha
Singh, Harpreet
Jani, Chinmay
Banankhah, Peymaan
Abdalla, Mohammed
Kurman, Jonathan S.
Franco, Rose A.
author_sort Agarwal, Lipisha
collection PubMed
description Bordetella bronchiseptica is a pleomorphic gram-negative coccobacillus that commonly causes respiratory tract infections in canines, felines, and swine. Human infections are rare. We report a case of Bordetella bronchiseptica pneumonia in a 67-year-old immunocompromised host. His past medical history included multiple myeloma treated with autologous bone marrow transplant followed by a chimeric antigen receptor cell therapy for relapse. He was admitted with unrelenting diarrhea due to HHV-6 pancolitis. During the hospital course he developed high-grade fever (102.3°F), cough and respiratory failure requiring mechanical ventilation. Chest imaging demonstrated bilateral opacities most pronounced at lung bases and worsening mediastinal lymphadenopathy. Bronchoalveolar lavage cultures grew Bordetella bronchiseptica. He was treated with piperacillin/tazobactam, but developed progressive multiorgan failure, transitioned to comfort care, and expired in the hospital. Bordetella bronchiseptica is an organism that do not cause serious infection in immunocompetent persons but can sometimes cause serious illness in immunocompromised populations. It causes “kennel cough” in dogs and spready by respiratory droplets. Dogs and cats are not uniformly vaccinated against this pathogen. Therefore, transmission through animal contact is becoming increasingly common. Realize that unlike other Bordetella spp, this pathogen is not typically responsive to erythromycin and is often resistant to ampicillin and cephalosporins so the typical neutropenic fever coverage with an antipseudomonal cephalosporin and azithromycin might not be effective. Given the increasing recognition of this zoonosis as a threat to the immunocompromised, it is essential to educate immunocompromised patients to minimize zoonotic exposure, as immunization of pets might not confer protection to humans.
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spelling pubmed-91491812022-05-31 A wolf in sheep's clothing: Dogs confer an unrecognized risk for their immunocompromised master Agarwal, Lipisha Singh, Harpreet Jani, Chinmay Banankhah, Peymaan Abdalla, Mohammed Kurman, Jonathan S. Franco, Rose A. Respir Med Case Rep Case Report Bordetella bronchiseptica is a pleomorphic gram-negative coccobacillus that commonly causes respiratory tract infections in canines, felines, and swine. Human infections are rare. We report a case of Bordetella bronchiseptica pneumonia in a 67-year-old immunocompromised host. His past medical history included multiple myeloma treated with autologous bone marrow transplant followed by a chimeric antigen receptor cell therapy for relapse. He was admitted with unrelenting diarrhea due to HHV-6 pancolitis. During the hospital course he developed high-grade fever (102.3°F), cough and respiratory failure requiring mechanical ventilation. Chest imaging demonstrated bilateral opacities most pronounced at lung bases and worsening mediastinal lymphadenopathy. Bronchoalveolar lavage cultures grew Bordetella bronchiseptica. He was treated with piperacillin/tazobactam, but developed progressive multiorgan failure, transitioned to comfort care, and expired in the hospital. Bordetella bronchiseptica is an organism that do not cause serious infection in immunocompetent persons but can sometimes cause serious illness in immunocompromised populations. It causes “kennel cough” in dogs and spready by respiratory droplets. Dogs and cats are not uniformly vaccinated against this pathogen. Therefore, transmission through animal contact is becoming increasingly common. Realize that unlike other Bordetella spp, this pathogen is not typically responsive to erythromycin and is often resistant to ampicillin and cephalosporins so the typical neutropenic fever coverage with an antipseudomonal cephalosporin and azithromycin might not be effective. Given the increasing recognition of this zoonosis as a threat to the immunocompromised, it is essential to educate immunocompromised patients to minimize zoonotic exposure, as immunization of pets might not confer protection to humans. Elsevier 2022-05-25 /pmc/articles/PMC9149181/ /pubmed/35651518 http://dx.doi.org/10.1016/j.rmcr.2022.101672 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Agarwal, Lipisha
Singh, Harpreet
Jani, Chinmay
Banankhah, Peymaan
Abdalla, Mohammed
Kurman, Jonathan S.
Franco, Rose A.
A wolf in sheep's clothing: Dogs confer an unrecognized risk for their immunocompromised master
title A wolf in sheep's clothing: Dogs confer an unrecognized risk for their immunocompromised master
title_full A wolf in sheep's clothing: Dogs confer an unrecognized risk for their immunocompromised master
title_fullStr A wolf in sheep's clothing: Dogs confer an unrecognized risk for their immunocompromised master
title_full_unstemmed A wolf in sheep's clothing: Dogs confer an unrecognized risk for their immunocompromised master
title_short A wolf in sheep's clothing: Dogs confer an unrecognized risk for their immunocompromised master
title_sort wolf in sheep's clothing: dogs confer an unrecognized risk for their immunocompromised master
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9149181/
https://www.ncbi.nlm.nih.gov/pubmed/35651518
http://dx.doi.org/10.1016/j.rmcr.2022.101672
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