Cargando…
Effect of 8 Weeks milk thistle powder (silymarin extract) supplementation on fatty liver disease in patients candidates for bariatric surgery
INTRODUCTION: Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide and is becoming the most frequent indication of liver transplantation. At present, since no Food and Drug Association (FDA) approved medication exists for NAFLD patients, bariatric surgery is indicated...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9149185/ https://www.ncbi.nlm.nih.gov/pubmed/35651885 http://dx.doi.org/10.1016/j.metop.2022.100190 |
_version_ | 1784717151433654272 |
---|---|
author | Mirhashemi, Seyed Hadi Hakakzadeh, Azadeh Yeganeh, Farbod Emami Oshidari, Bahador Rezaee, Seyed Parviz |
author_facet | Mirhashemi, Seyed Hadi Hakakzadeh, Azadeh Yeganeh, Farbod Emami Oshidari, Bahador Rezaee, Seyed Parviz |
author_sort | Mirhashemi, Seyed Hadi |
collection | PubMed |
description | INTRODUCTION: Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide and is becoming the most frequent indication of liver transplantation. At present, since no Food and Drug Association (FDA) approved medication exists for NAFLD patients, bariatric surgery is indicated for the significant improvement in obesity-related comorbidities, such as NAFLD. However, alternative therapy is emerging to manage NAFLD. Problematically, many patients taking herbal remedies, such as Silymarin (milk thistle), with little/no understanding of its purported properties. METHODS: Fifty-two morbidly-obese (47.84 ± 6.48 kg m(−2)) patient candidates (mean age: 38.90 ± 10.28 years; n = 41 women and 11 men) for bariatric surgery with NAFLD were randomly assigned to determine the efficacy of eight weeks of Silymarin supplementation (140 mg four times daily for a total of 560 mg) on the aspartate transaminase (AST)/alanine transaminase (ALT) (AST/ALT) ratio, Fibrosis-4 (Fib-4) score, NAFLD score, sonographic grading, and fibroscan stages of NAFLD. RESULTS: Significant (p ≤ 0.05) improvements were found in AST/ALT ratio, BMI and sonographic grading. No significant change was found for fibroscan staging, Fib-4, and NAFLD scores. CONCLUSION: Silymarin improved ultrasound fatty liver grading and liver enzymes morbidly-obese patient candidates for bariatric surgery with NAFLD after only eight weeks, without any adverse effects. |
format | Online Article Text |
id | pubmed-9149185 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-91491852022-05-31 Effect of 8 Weeks milk thistle powder (silymarin extract) supplementation on fatty liver disease in patients candidates for bariatric surgery Mirhashemi, Seyed Hadi Hakakzadeh, Azadeh Yeganeh, Farbod Emami Oshidari, Bahador Rezaee, Seyed Parviz Metabol Open Articles from the NAFLD: from Molecular Basis to Therapeutic Advances Special Issue INTRODUCTION: Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide and is becoming the most frequent indication of liver transplantation. At present, since no Food and Drug Association (FDA) approved medication exists for NAFLD patients, bariatric surgery is indicated for the significant improvement in obesity-related comorbidities, such as NAFLD. However, alternative therapy is emerging to manage NAFLD. Problematically, many patients taking herbal remedies, such as Silymarin (milk thistle), with little/no understanding of its purported properties. METHODS: Fifty-two morbidly-obese (47.84 ± 6.48 kg m(−2)) patient candidates (mean age: 38.90 ± 10.28 years; n = 41 women and 11 men) for bariatric surgery with NAFLD were randomly assigned to determine the efficacy of eight weeks of Silymarin supplementation (140 mg four times daily for a total of 560 mg) on the aspartate transaminase (AST)/alanine transaminase (ALT) (AST/ALT) ratio, Fibrosis-4 (Fib-4) score, NAFLD score, sonographic grading, and fibroscan stages of NAFLD. RESULTS: Significant (p ≤ 0.05) improvements were found in AST/ALT ratio, BMI and sonographic grading. No significant change was found for fibroscan staging, Fib-4, and NAFLD scores. CONCLUSION: Silymarin improved ultrasound fatty liver grading and liver enzymes morbidly-obese patient candidates for bariatric surgery with NAFLD after only eight weeks, without any adverse effects. Elsevier 2022-05-21 /pmc/articles/PMC9149185/ /pubmed/35651885 http://dx.doi.org/10.1016/j.metop.2022.100190 Text en © 2022 The Authors. Published by Elsevier Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Articles from the NAFLD: from Molecular Basis to Therapeutic Advances Special Issue Mirhashemi, Seyed Hadi Hakakzadeh, Azadeh Yeganeh, Farbod Emami Oshidari, Bahador Rezaee, Seyed Parviz Effect of 8 Weeks milk thistle powder (silymarin extract) supplementation on fatty liver disease in patients candidates for bariatric surgery |
title | Effect of 8 Weeks milk thistle powder (silymarin extract) supplementation on fatty liver disease in patients candidates for bariatric surgery |
title_full | Effect of 8 Weeks milk thistle powder (silymarin extract) supplementation on fatty liver disease in patients candidates for bariatric surgery |
title_fullStr | Effect of 8 Weeks milk thistle powder (silymarin extract) supplementation on fatty liver disease in patients candidates for bariatric surgery |
title_full_unstemmed | Effect of 8 Weeks milk thistle powder (silymarin extract) supplementation on fatty liver disease in patients candidates for bariatric surgery |
title_short | Effect of 8 Weeks milk thistle powder (silymarin extract) supplementation on fatty liver disease in patients candidates for bariatric surgery |
title_sort | effect of 8 weeks milk thistle powder (silymarin extract) supplementation on fatty liver disease in patients candidates for bariatric surgery |
topic | Articles from the NAFLD: from Molecular Basis to Therapeutic Advances Special Issue |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9149185/ https://www.ncbi.nlm.nih.gov/pubmed/35651885 http://dx.doi.org/10.1016/j.metop.2022.100190 |
work_keys_str_mv | AT mirhashemiseyedhadi effectof8weeksmilkthistlepowdersilymarinextractsupplementationonfattyliverdiseaseinpatientscandidatesforbariatricsurgery AT hakakzadehazadeh effectof8weeksmilkthistlepowdersilymarinextractsupplementationonfattyliverdiseaseinpatientscandidatesforbariatricsurgery AT yeganehfarbodemami effectof8weeksmilkthistlepowdersilymarinextractsupplementationonfattyliverdiseaseinpatientscandidatesforbariatricsurgery AT oshidaribahador effectof8weeksmilkthistlepowdersilymarinextractsupplementationonfattyliverdiseaseinpatientscandidatesforbariatricsurgery AT rezaeeseyedparviz effectof8weeksmilkthistlepowdersilymarinextractsupplementationonfattyliverdiseaseinpatientscandidatesforbariatricsurgery |