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Effect of 8 Weeks milk thistle powder (silymarin extract) supplementation on fatty liver disease in patients candidates for bariatric surgery

INTRODUCTION: Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide and is becoming the most frequent indication of liver transplantation. At present, since no Food and Drug Association (FDA) approved medication exists for NAFLD patients, bariatric surgery is indicated...

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Autores principales: Mirhashemi, Seyed Hadi, Hakakzadeh, Azadeh, Yeganeh, Farbod Emami, Oshidari, Bahador, Rezaee, Seyed Parviz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9149185/
https://www.ncbi.nlm.nih.gov/pubmed/35651885
http://dx.doi.org/10.1016/j.metop.2022.100190
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author Mirhashemi, Seyed Hadi
Hakakzadeh, Azadeh
Yeganeh, Farbod Emami
Oshidari, Bahador
Rezaee, Seyed Parviz
author_facet Mirhashemi, Seyed Hadi
Hakakzadeh, Azadeh
Yeganeh, Farbod Emami
Oshidari, Bahador
Rezaee, Seyed Parviz
author_sort Mirhashemi, Seyed Hadi
collection PubMed
description INTRODUCTION: Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide and is becoming the most frequent indication of liver transplantation. At present, since no Food and Drug Association (FDA) approved medication exists for NAFLD patients, bariatric surgery is indicated for the significant improvement in obesity-related comorbidities, such as NAFLD. However, alternative therapy is emerging to manage NAFLD. Problematically, many patients taking herbal remedies, such as Silymarin (milk thistle), with little/no understanding of its purported properties. METHODS: Fifty-two morbidly-obese (47.84 ± 6.48 kg m(−2)) patient candidates (mean age: 38.90 ± 10.28 years; n = 41 women and 11 men) for bariatric surgery with NAFLD were randomly assigned to determine the efficacy of eight weeks of Silymarin supplementation (140 mg four times daily for a total of 560 mg) on the aspartate transaminase (AST)/alanine transaminase (ALT) (AST/ALT) ratio, Fibrosis-4 (Fib-4) score, NAFLD score, sonographic grading, and fibroscan stages of NAFLD. RESULTS: Significant (p ≤ 0.05) improvements were found in AST/ALT ratio, BMI and sonographic grading. No significant change was found for fibroscan staging, Fib-4, and NAFLD scores. CONCLUSION: Silymarin improved ultrasound fatty liver grading and liver enzymes morbidly-obese patient candidates for bariatric surgery with NAFLD after only eight weeks, without any adverse effects.
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spelling pubmed-91491852022-05-31 Effect of 8 Weeks milk thistle powder (silymarin extract) supplementation on fatty liver disease in patients candidates for bariatric surgery Mirhashemi, Seyed Hadi Hakakzadeh, Azadeh Yeganeh, Farbod Emami Oshidari, Bahador Rezaee, Seyed Parviz Metabol Open Articles from the NAFLD: from Molecular Basis to Therapeutic Advances Special Issue INTRODUCTION: Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide and is becoming the most frequent indication of liver transplantation. At present, since no Food and Drug Association (FDA) approved medication exists for NAFLD patients, bariatric surgery is indicated for the significant improvement in obesity-related comorbidities, such as NAFLD. However, alternative therapy is emerging to manage NAFLD. Problematically, many patients taking herbal remedies, such as Silymarin (milk thistle), with little/no understanding of its purported properties. METHODS: Fifty-two morbidly-obese (47.84 ± 6.48 kg m(−2)) patient candidates (mean age: 38.90 ± 10.28 years; n = 41 women and 11 men) for bariatric surgery with NAFLD were randomly assigned to determine the efficacy of eight weeks of Silymarin supplementation (140 mg four times daily for a total of 560 mg) on the aspartate transaminase (AST)/alanine transaminase (ALT) (AST/ALT) ratio, Fibrosis-4 (Fib-4) score, NAFLD score, sonographic grading, and fibroscan stages of NAFLD. RESULTS: Significant (p ≤ 0.05) improvements were found in AST/ALT ratio, BMI and sonographic grading. No significant change was found for fibroscan staging, Fib-4, and NAFLD scores. CONCLUSION: Silymarin improved ultrasound fatty liver grading and liver enzymes morbidly-obese patient candidates for bariatric surgery with NAFLD after only eight weeks, without any adverse effects. Elsevier 2022-05-21 /pmc/articles/PMC9149185/ /pubmed/35651885 http://dx.doi.org/10.1016/j.metop.2022.100190 Text en © 2022 The Authors. Published by Elsevier Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Articles from the NAFLD: from Molecular Basis to Therapeutic Advances Special Issue
Mirhashemi, Seyed Hadi
Hakakzadeh, Azadeh
Yeganeh, Farbod Emami
Oshidari, Bahador
Rezaee, Seyed Parviz
Effect of 8 Weeks milk thistle powder (silymarin extract) supplementation on fatty liver disease in patients candidates for bariatric surgery
title Effect of 8 Weeks milk thistle powder (silymarin extract) supplementation on fatty liver disease in patients candidates for bariatric surgery
title_full Effect of 8 Weeks milk thistle powder (silymarin extract) supplementation on fatty liver disease in patients candidates for bariatric surgery
title_fullStr Effect of 8 Weeks milk thistle powder (silymarin extract) supplementation on fatty liver disease in patients candidates for bariatric surgery
title_full_unstemmed Effect of 8 Weeks milk thistle powder (silymarin extract) supplementation on fatty liver disease in patients candidates for bariatric surgery
title_short Effect of 8 Weeks milk thistle powder (silymarin extract) supplementation on fatty liver disease in patients candidates for bariatric surgery
title_sort effect of 8 weeks milk thistle powder (silymarin extract) supplementation on fatty liver disease in patients candidates for bariatric surgery
topic Articles from the NAFLD: from Molecular Basis to Therapeutic Advances Special Issue
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9149185/
https://www.ncbi.nlm.nih.gov/pubmed/35651885
http://dx.doi.org/10.1016/j.metop.2022.100190
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