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Nivolumab-Induced de novo Discoid Lupus Erythematosus
An increasing number of checkpoint inhibitor-induced subacute cutaneous lupus erythematosus events have been reported. We present the first case of nivolumab-induced discoid lupus erythematosus in a patient with hepatocellular carcinoma. The patient presents with violaceous hypopigmented plaques on...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
S. Karger AG
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9149346/ https://www.ncbi.nlm.nih.gov/pubmed/35702724 http://dx.doi.org/10.1159/000523800 |
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author | Manjunath, Jaya Mochel, Mark Nutan, Fnu |
author_facet | Manjunath, Jaya Mochel, Mark Nutan, Fnu |
author_sort | Manjunath, Jaya |
collection | PubMed |
description | An increasing number of checkpoint inhibitor-induced subacute cutaneous lupus erythematosus events have been reported. We present the first case of nivolumab-induced discoid lupus erythematosus in a patient with hepatocellular carcinoma. The patient presents with violaceous hypopigmented plaques on the pinna bilaterally, hypopigmented plaques with central hyperpigmentation on the posterior neck, and other hypopigmented plaques on the face, forearms, and hands. For management, nivolumab was held for 2 months, and Plaquenil and topical steroids were added. Nivolumab was resumed with no further progression of DLE lesions and improvement of the skin. It is important to characterize cutaneous side effects to effectively manage them. |
format | Online Article Text |
id | pubmed-9149346 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | S. Karger AG |
record_format | MEDLINE/PubMed |
spelling | pubmed-91493462022-06-13 Nivolumab-Induced de novo Discoid Lupus Erythematosus Manjunath, Jaya Mochel, Mark Nutan, Fnu Case Rep Dermatol Single Case An increasing number of checkpoint inhibitor-induced subacute cutaneous lupus erythematosus events have been reported. We present the first case of nivolumab-induced discoid lupus erythematosus in a patient with hepatocellular carcinoma. The patient presents with violaceous hypopigmented plaques on the pinna bilaterally, hypopigmented plaques with central hyperpigmentation on the posterior neck, and other hypopigmented plaques on the face, forearms, and hands. For management, nivolumab was held for 2 months, and Plaquenil and topical steroids were added. Nivolumab was resumed with no further progression of DLE lesions and improvement of the skin. It is important to characterize cutaneous side effects to effectively manage them. S. Karger AG 2022-04-21 /pmc/articles/PMC9149346/ /pubmed/35702724 http://dx.doi.org/10.1159/000523800 Text en Copyright © 2022 by S. Karger AG, Basel https://creativecommons.org/licenses/by-nc/4.0/This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission. |
spellingShingle | Single Case Manjunath, Jaya Mochel, Mark Nutan, Fnu Nivolumab-Induced de novo Discoid Lupus Erythematosus |
title | Nivolumab-Induced de novo Discoid Lupus Erythematosus |
title_full | Nivolumab-Induced de novo Discoid Lupus Erythematosus |
title_fullStr | Nivolumab-Induced de novo Discoid Lupus Erythematosus |
title_full_unstemmed | Nivolumab-Induced de novo Discoid Lupus Erythematosus |
title_short | Nivolumab-Induced de novo Discoid Lupus Erythematosus |
title_sort | nivolumab-induced de novo discoid lupus erythematosus |
topic | Single Case |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9149346/ https://www.ncbi.nlm.nih.gov/pubmed/35702724 http://dx.doi.org/10.1159/000523800 |
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