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Spontaneous Tumor Lysis Syndrome in a Patient with Bulky Chronic Lymphocytic Leukemia Diagnosed after Resolution of Symptoms

Tumor lysis syndrome (TLS) is an oncologic emergency characterized by the destruction of tumor cells leading to an influx of large amounts of uric acid, potassium, and phosphorus into systemic circulation. It most often occurs after the initiation of cytotoxic therapy in high-grade lymphomas and leu...

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Autores principales: Menakuru, Sasmith R., Priscu, Adelina, Khan, Ibrahim, Beirat, Amir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9149513/
https://www.ncbi.nlm.nih.gov/pubmed/35702553
http://dx.doi.org/10.1159/000524198
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author Menakuru, Sasmith R.
Priscu, Adelina
Khan, Ibrahim
Beirat, Amir
author_facet Menakuru, Sasmith R.
Priscu, Adelina
Khan, Ibrahim
Beirat, Amir
author_sort Menakuru, Sasmith R.
collection PubMed
description Tumor lysis syndrome (TLS) is an oncologic emergency characterized by the destruction of tumor cells leading to an influx of large amounts of uric acid, potassium, and phosphorus into systemic circulation. It most often occurs after the initiation of cytotoxic therapy in high-grade lymphomas and leukemias; however, rarely it may occur spontaneously. The authors report a case of spontaneous tumor lysis causing electrolyte abnormalities and acute kidney injury in a patient with subsequently diagnosed large chronic lymphocytic leukemia tumor burden. Spontaneous TLS can be the first presentation of underlying malignancy; therefore, physicians should be aware of the associated findings.
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spelling pubmed-91495132022-06-13 Spontaneous Tumor Lysis Syndrome in a Patient with Bulky Chronic Lymphocytic Leukemia Diagnosed after Resolution of Symptoms Menakuru, Sasmith R. Priscu, Adelina Khan, Ibrahim Beirat, Amir Case Rep Oncol Case Report Tumor lysis syndrome (TLS) is an oncologic emergency characterized by the destruction of tumor cells leading to an influx of large amounts of uric acid, potassium, and phosphorus into systemic circulation. It most often occurs after the initiation of cytotoxic therapy in high-grade lymphomas and leukemias; however, rarely it may occur spontaneously. The authors report a case of spontaneous tumor lysis causing electrolyte abnormalities and acute kidney injury in a patient with subsequently diagnosed large chronic lymphocytic leukemia tumor burden. Spontaneous TLS can be the first presentation of underlying malignancy; therefore, physicians should be aware of the associated findings. S. Karger AG 2022-04-22 /pmc/articles/PMC9149513/ /pubmed/35702553 http://dx.doi.org/10.1159/000524198 Text en Copyright © 2022 by S. Karger AG, Basel https://creativecommons.org/licenses/by-nc/4.0/This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Case Report
Menakuru, Sasmith R.
Priscu, Adelina
Khan, Ibrahim
Beirat, Amir
Spontaneous Tumor Lysis Syndrome in a Patient with Bulky Chronic Lymphocytic Leukemia Diagnosed after Resolution of Symptoms
title Spontaneous Tumor Lysis Syndrome in a Patient with Bulky Chronic Lymphocytic Leukemia Diagnosed after Resolution of Symptoms
title_full Spontaneous Tumor Lysis Syndrome in a Patient with Bulky Chronic Lymphocytic Leukemia Diagnosed after Resolution of Symptoms
title_fullStr Spontaneous Tumor Lysis Syndrome in a Patient with Bulky Chronic Lymphocytic Leukemia Diagnosed after Resolution of Symptoms
title_full_unstemmed Spontaneous Tumor Lysis Syndrome in a Patient with Bulky Chronic Lymphocytic Leukemia Diagnosed after Resolution of Symptoms
title_short Spontaneous Tumor Lysis Syndrome in a Patient with Bulky Chronic Lymphocytic Leukemia Diagnosed after Resolution of Symptoms
title_sort spontaneous tumor lysis syndrome in a patient with bulky chronic lymphocytic leukemia diagnosed after resolution of symptoms
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9149513/
https://www.ncbi.nlm.nih.gov/pubmed/35702553
http://dx.doi.org/10.1159/000524198
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