Cargando…

Targeting Differential Roles of Tumor Necrosis Factor Receptors as a Therapeutic Strategy for Glaucoma

Glaucoma is an irreversible sight-threatening disorder primarily due to elevated intraocular pressure (IOP), leading to retinal ganglion cell (RGC) death by apoptosis with subsequent loss of optic nerve fibers. A considerable amount of empirical evidence has shown the significant association between...

Descripción completa

Detalles Bibliográficos
Autores principales: Lambuk, Lidawani, Ahmad, Suhana, Sadikan, Muhammad Zulfiqah, Nordin, Nor Asyikin, Kadir, Ramlah, Nasir, Nurul Alimah Abdul, Chen, Xin, Boer, Jennifer, Plebanski, Magdalena, Mohamud, Rohimah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9149562/
https://www.ncbi.nlm.nih.gov/pubmed/35651608
http://dx.doi.org/10.3389/fimmu.2022.857812
_version_ 1784717227173347328
author Lambuk, Lidawani
Ahmad, Suhana
Sadikan, Muhammad Zulfiqah
Nordin, Nor Asyikin
Kadir, Ramlah
Nasir, Nurul Alimah Abdul
Chen, Xin
Boer, Jennifer
Plebanski, Magdalena
Mohamud, Rohimah
author_facet Lambuk, Lidawani
Ahmad, Suhana
Sadikan, Muhammad Zulfiqah
Nordin, Nor Asyikin
Kadir, Ramlah
Nasir, Nurul Alimah Abdul
Chen, Xin
Boer, Jennifer
Plebanski, Magdalena
Mohamud, Rohimah
author_sort Lambuk, Lidawani
collection PubMed
description Glaucoma is an irreversible sight-threatening disorder primarily due to elevated intraocular pressure (IOP), leading to retinal ganglion cell (RGC) death by apoptosis with subsequent loss of optic nerve fibers. A considerable amount of empirical evidence has shown the significant association between tumor necrosis factor cytokine (TNF; TNFα) and glaucoma; however, the exact role of TNF in glaucoma progression remains unclear. Total inhibition of TNF against its receptors can cause side effects, although this is not the case when using selective inhibitors. In addition, TNF exerts its antithetic roles via stimulation of two receptors, TNF receptor I (TNFR1) and TNF receptor II (TNFR2). The pro-inflammatory responses and proapoptotic signaling pathways predominantly mediated through TNFR1, while neuroprotective and anti-apoptotic signals induced by TNFR2. In this review, we attempt to discuss the involvement of TNF receptors (TNFRs) and their signaling pathway in ocular tissues with focus on RGC and glial cells in glaucoma. This review also outlines the potential application TNFRs agonist and/or antagonists as neuroprotective strategy from a therapeutic standpoint. Taken together, a better understanding of the function of TNFRs may lead to the development of a treatment for glaucoma.
format Online
Article
Text
id pubmed-9149562
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-91495622022-05-31 Targeting Differential Roles of Tumor Necrosis Factor Receptors as a Therapeutic Strategy for Glaucoma Lambuk, Lidawani Ahmad, Suhana Sadikan, Muhammad Zulfiqah Nordin, Nor Asyikin Kadir, Ramlah Nasir, Nurul Alimah Abdul Chen, Xin Boer, Jennifer Plebanski, Magdalena Mohamud, Rohimah Front Immunol Immunology Glaucoma is an irreversible sight-threatening disorder primarily due to elevated intraocular pressure (IOP), leading to retinal ganglion cell (RGC) death by apoptosis with subsequent loss of optic nerve fibers. A considerable amount of empirical evidence has shown the significant association between tumor necrosis factor cytokine (TNF; TNFα) and glaucoma; however, the exact role of TNF in glaucoma progression remains unclear. Total inhibition of TNF against its receptors can cause side effects, although this is not the case when using selective inhibitors. In addition, TNF exerts its antithetic roles via stimulation of two receptors, TNF receptor I (TNFR1) and TNF receptor II (TNFR2). The pro-inflammatory responses and proapoptotic signaling pathways predominantly mediated through TNFR1, while neuroprotective and anti-apoptotic signals induced by TNFR2. In this review, we attempt to discuss the involvement of TNF receptors (TNFRs) and their signaling pathway in ocular tissues with focus on RGC and glial cells in glaucoma. This review also outlines the potential application TNFRs agonist and/or antagonists as neuroprotective strategy from a therapeutic standpoint. Taken together, a better understanding of the function of TNFRs may lead to the development of a treatment for glaucoma. Frontiers Media S.A. 2022-05-16 /pmc/articles/PMC9149562/ /pubmed/35651608 http://dx.doi.org/10.3389/fimmu.2022.857812 Text en Copyright © 2022 Lambuk, Ahmad, Sadikan, Nordin, Kadir, Nasir, Chen, Boer, Plebanski and Mohamud https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Lambuk, Lidawani
Ahmad, Suhana
Sadikan, Muhammad Zulfiqah
Nordin, Nor Asyikin
Kadir, Ramlah
Nasir, Nurul Alimah Abdul
Chen, Xin
Boer, Jennifer
Plebanski, Magdalena
Mohamud, Rohimah
Targeting Differential Roles of Tumor Necrosis Factor Receptors as a Therapeutic Strategy for Glaucoma
title Targeting Differential Roles of Tumor Necrosis Factor Receptors as a Therapeutic Strategy for Glaucoma
title_full Targeting Differential Roles of Tumor Necrosis Factor Receptors as a Therapeutic Strategy for Glaucoma
title_fullStr Targeting Differential Roles of Tumor Necrosis Factor Receptors as a Therapeutic Strategy for Glaucoma
title_full_unstemmed Targeting Differential Roles of Tumor Necrosis Factor Receptors as a Therapeutic Strategy for Glaucoma
title_short Targeting Differential Roles of Tumor Necrosis Factor Receptors as a Therapeutic Strategy for Glaucoma
title_sort targeting differential roles of tumor necrosis factor receptors as a therapeutic strategy for glaucoma
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9149562/
https://www.ncbi.nlm.nih.gov/pubmed/35651608
http://dx.doi.org/10.3389/fimmu.2022.857812
work_keys_str_mv AT lambuklidawani targetingdifferentialrolesoftumornecrosisfactorreceptorsasatherapeuticstrategyforglaucoma
AT ahmadsuhana targetingdifferentialrolesoftumornecrosisfactorreceptorsasatherapeuticstrategyforglaucoma
AT sadikanmuhammadzulfiqah targetingdifferentialrolesoftumornecrosisfactorreceptorsasatherapeuticstrategyforglaucoma
AT nordinnorasyikin targetingdifferentialrolesoftumornecrosisfactorreceptorsasatherapeuticstrategyforglaucoma
AT kadirramlah targetingdifferentialrolesoftumornecrosisfactorreceptorsasatherapeuticstrategyforglaucoma
AT nasirnurulalimahabdul targetingdifferentialrolesoftumornecrosisfactorreceptorsasatherapeuticstrategyforglaucoma
AT chenxin targetingdifferentialrolesoftumornecrosisfactorreceptorsasatherapeuticstrategyforglaucoma
AT boerjennifer targetingdifferentialrolesoftumornecrosisfactorreceptorsasatherapeuticstrategyforglaucoma
AT plebanskimagdalena targetingdifferentialrolesoftumornecrosisfactorreceptorsasatherapeuticstrategyforglaucoma
AT mohamudrohimah targetingdifferentialrolesoftumornecrosisfactorreceptorsasatherapeuticstrategyforglaucoma