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Targeting Differential Roles of Tumor Necrosis Factor Receptors as a Therapeutic Strategy for Glaucoma
Glaucoma is an irreversible sight-threatening disorder primarily due to elevated intraocular pressure (IOP), leading to retinal ganglion cell (RGC) death by apoptosis with subsequent loss of optic nerve fibers. A considerable amount of empirical evidence has shown the significant association between...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9149562/ https://www.ncbi.nlm.nih.gov/pubmed/35651608 http://dx.doi.org/10.3389/fimmu.2022.857812 |
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author | Lambuk, Lidawani Ahmad, Suhana Sadikan, Muhammad Zulfiqah Nordin, Nor Asyikin Kadir, Ramlah Nasir, Nurul Alimah Abdul Chen, Xin Boer, Jennifer Plebanski, Magdalena Mohamud, Rohimah |
author_facet | Lambuk, Lidawani Ahmad, Suhana Sadikan, Muhammad Zulfiqah Nordin, Nor Asyikin Kadir, Ramlah Nasir, Nurul Alimah Abdul Chen, Xin Boer, Jennifer Plebanski, Magdalena Mohamud, Rohimah |
author_sort | Lambuk, Lidawani |
collection | PubMed |
description | Glaucoma is an irreversible sight-threatening disorder primarily due to elevated intraocular pressure (IOP), leading to retinal ganglion cell (RGC) death by apoptosis with subsequent loss of optic nerve fibers. A considerable amount of empirical evidence has shown the significant association between tumor necrosis factor cytokine (TNF; TNFα) and glaucoma; however, the exact role of TNF in glaucoma progression remains unclear. Total inhibition of TNF against its receptors can cause side effects, although this is not the case when using selective inhibitors. In addition, TNF exerts its antithetic roles via stimulation of two receptors, TNF receptor I (TNFR1) and TNF receptor II (TNFR2). The pro-inflammatory responses and proapoptotic signaling pathways predominantly mediated through TNFR1, while neuroprotective and anti-apoptotic signals induced by TNFR2. In this review, we attempt to discuss the involvement of TNF receptors (TNFRs) and their signaling pathway in ocular tissues with focus on RGC and glial cells in glaucoma. This review also outlines the potential application TNFRs agonist and/or antagonists as neuroprotective strategy from a therapeutic standpoint. Taken together, a better understanding of the function of TNFRs may lead to the development of a treatment for glaucoma. |
format | Online Article Text |
id | pubmed-9149562 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-91495622022-05-31 Targeting Differential Roles of Tumor Necrosis Factor Receptors as a Therapeutic Strategy for Glaucoma Lambuk, Lidawani Ahmad, Suhana Sadikan, Muhammad Zulfiqah Nordin, Nor Asyikin Kadir, Ramlah Nasir, Nurul Alimah Abdul Chen, Xin Boer, Jennifer Plebanski, Magdalena Mohamud, Rohimah Front Immunol Immunology Glaucoma is an irreversible sight-threatening disorder primarily due to elevated intraocular pressure (IOP), leading to retinal ganglion cell (RGC) death by apoptosis with subsequent loss of optic nerve fibers. A considerable amount of empirical evidence has shown the significant association between tumor necrosis factor cytokine (TNF; TNFα) and glaucoma; however, the exact role of TNF in glaucoma progression remains unclear. Total inhibition of TNF against its receptors can cause side effects, although this is not the case when using selective inhibitors. In addition, TNF exerts its antithetic roles via stimulation of two receptors, TNF receptor I (TNFR1) and TNF receptor II (TNFR2). The pro-inflammatory responses and proapoptotic signaling pathways predominantly mediated through TNFR1, while neuroprotective and anti-apoptotic signals induced by TNFR2. In this review, we attempt to discuss the involvement of TNF receptors (TNFRs) and their signaling pathway in ocular tissues with focus on RGC and glial cells in glaucoma. This review also outlines the potential application TNFRs agonist and/or antagonists as neuroprotective strategy from a therapeutic standpoint. Taken together, a better understanding of the function of TNFRs may lead to the development of a treatment for glaucoma. Frontiers Media S.A. 2022-05-16 /pmc/articles/PMC9149562/ /pubmed/35651608 http://dx.doi.org/10.3389/fimmu.2022.857812 Text en Copyright © 2022 Lambuk, Ahmad, Sadikan, Nordin, Kadir, Nasir, Chen, Boer, Plebanski and Mohamud https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Lambuk, Lidawani Ahmad, Suhana Sadikan, Muhammad Zulfiqah Nordin, Nor Asyikin Kadir, Ramlah Nasir, Nurul Alimah Abdul Chen, Xin Boer, Jennifer Plebanski, Magdalena Mohamud, Rohimah Targeting Differential Roles of Tumor Necrosis Factor Receptors as a Therapeutic Strategy for Glaucoma |
title | Targeting Differential Roles of Tumor Necrosis Factor Receptors as a Therapeutic Strategy for Glaucoma |
title_full | Targeting Differential Roles of Tumor Necrosis Factor Receptors as a Therapeutic Strategy for Glaucoma |
title_fullStr | Targeting Differential Roles of Tumor Necrosis Factor Receptors as a Therapeutic Strategy for Glaucoma |
title_full_unstemmed | Targeting Differential Roles of Tumor Necrosis Factor Receptors as a Therapeutic Strategy for Glaucoma |
title_short | Targeting Differential Roles of Tumor Necrosis Factor Receptors as a Therapeutic Strategy for Glaucoma |
title_sort | targeting differential roles of tumor necrosis factor receptors as a therapeutic strategy for glaucoma |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9149562/ https://www.ncbi.nlm.nih.gov/pubmed/35651608 http://dx.doi.org/10.3389/fimmu.2022.857812 |
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