Research Progress on Mono-ADP-Ribosyltransferases in Human Cell Biology

ADP-ribosylation is a well-established post-translational modification that is inherently connected to diverse processes, including DNA repair, transcription, and cell signaling. The crucial roles of mono-ADP-ribosyltransferases (mono-ARTs) in biological processes have been identified in recent year...

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Autores principales: Gan, Yujie, Sha, Huanhuan, Zou, Renrui, Xu, Miao, Zhang, Yuan, Feng, Jifeng, Wu, Jianzhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9149570/
https://www.ncbi.nlm.nih.gov/pubmed/35652091
http://dx.doi.org/10.3389/fcell.2022.864101
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author Gan, Yujie
Sha, Huanhuan
Zou, Renrui
Xu, Miao
Zhang, Yuan
Feng, Jifeng
Wu, Jianzhong
author_facet Gan, Yujie
Sha, Huanhuan
Zou, Renrui
Xu, Miao
Zhang, Yuan
Feng, Jifeng
Wu, Jianzhong
author_sort Gan, Yujie
collection PubMed
description ADP-ribosylation is a well-established post-translational modification that is inherently connected to diverse processes, including DNA repair, transcription, and cell signaling. The crucial roles of mono-ADP-ribosyltransferases (mono-ARTs) in biological processes have been identified in recent years by the comprehensive use of genetic engineering, chemical genetics, and proteomics. This review provides an update on current methodological advances in the study of these modifiers. Furthermore, the review provides details on the function of mono ADP-ribosylation. Several mono-ARTs have been implicated in the development of cancer, and this review discusses the role and therapeutic potential of some mono-ARTs in cancer.
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spelling pubmed-91495702022-05-31 Research Progress on Mono-ADP-Ribosyltransferases in Human Cell Biology Gan, Yujie Sha, Huanhuan Zou, Renrui Xu, Miao Zhang, Yuan Feng, Jifeng Wu, Jianzhong Front Cell Dev Biol Cell and Developmental Biology ADP-ribosylation is a well-established post-translational modification that is inherently connected to diverse processes, including DNA repair, transcription, and cell signaling. The crucial roles of mono-ADP-ribosyltransferases (mono-ARTs) in biological processes have been identified in recent years by the comprehensive use of genetic engineering, chemical genetics, and proteomics. This review provides an update on current methodological advances in the study of these modifiers. Furthermore, the review provides details on the function of mono ADP-ribosylation. Several mono-ARTs have been implicated in the development of cancer, and this review discusses the role and therapeutic potential of some mono-ARTs in cancer. Frontiers Media S.A. 2022-05-16 /pmc/articles/PMC9149570/ /pubmed/35652091 http://dx.doi.org/10.3389/fcell.2022.864101 Text en Copyright © 2022 Gan, Sha, Zou, Xu, Zhang, Feng and Wu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Gan, Yujie
Sha, Huanhuan
Zou, Renrui
Xu, Miao
Zhang, Yuan
Feng, Jifeng
Wu, Jianzhong
Research Progress on Mono-ADP-Ribosyltransferases in Human Cell Biology
title Research Progress on Mono-ADP-Ribosyltransferases in Human Cell Biology
title_full Research Progress on Mono-ADP-Ribosyltransferases in Human Cell Biology
title_fullStr Research Progress on Mono-ADP-Ribosyltransferases in Human Cell Biology
title_full_unstemmed Research Progress on Mono-ADP-Ribosyltransferases in Human Cell Biology
title_short Research Progress on Mono-ADP-Ribosyltransferases in Human Cell Biology
title_sort research progress on mono-adp-ribosyltransferases in human cell biology
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9149570/
https://www.ncbi.nlm.nih.gov/pubmed/35652091
http://dx.doi.org/10.3389/fcell.2022.864101
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