Comorbid Psoriasis and Metabolic Syndrome: Clinical Implications and Optimal Management

PURPOSE: To review the literature on guidance on the follow-up of psoriasis and its comorbidities and to provide practical recommendations. PATIENTS AND METHODS: A PubMed search was conducted using MeSH terms and free text keywords related to “psoriasis”, “obesity”, “hypertension”, “diabetes”, “dyslipidemia”, “metabolic syndrome” and “Psoriatic arthritis”. The search was conducted between September 2021 and January 2022. References of selected articles were scanned to identify additional articles. RESULTS: Recommendations on the follow-up of hypertension, obesity, dyslipidemia, type 2 diabetes, metabolic syndrome, psoriatic arthritis, non-alcoholic fatty liver disease and inflammatory bowel disease in psoriasis patients were extracted from the included articles. These data are presented in summary tables for both adults and children. A practical and feasible approach for each comorbidity is discussed. CONCLUSION: Awareness among dermatologists for relevant psoriasis-associated comorbidities is crucial. The dermatologist should function as gatekeeper and screen for comorbidities, in order to make timely referrals when indicated.