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Sentence Comprehension in Primary Progressive Aphasia: A Study of the Application of the Brazilian Version of the Test for the Reception of Grammar (TROG2-Br)

Sentence-comprehension deficits have been described in patients with primary progressive aphasia (PPA). However, most instruments to address this domain in more detail and in a clinical context have not been adapted and translated into several languages, posing limitations to clinical practice and c...

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Autores principales: Carthery-Goulart, Maria Teresa, de Oliveira, Rosimeire, de Almeida, Isabel Junqueira, Campanha, Aline, da Silva Souza, Dayse, Zana, Yossi, Caramelli, Paulo, Machado, Thais Helena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9149594/
https://www.ncbi.nlm.nih.gov/pubmed/35651345
http://dx.doi.org/10.3389/fneur.2022.815227
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author Carthery-Goulart, Maria Teresa
de Oliveira, Rosimeire
de Almeida, Isabel Junqueira
Campanha, Aline
da Silva Souza, Dayse
Zana, Yossi
Caramelli, Paulo
Machado, Thais Helena
author_facet Carthery-Goulart, Maria Teresa
de Oliveira, Rosimeire
de Almeida, Isabel Junqueira
Campanha, Aline
da Silva Souza, Dayse
Zana, Yossi
Caramelli, Paulo
Machado, Thais Helena
author_sort Carthery-Goulart, Maria Teresa
collection PubMed
description Sentence-comprehension deficits have been described in patients with primary progressive aphasia (PPA). However, most instruments to address this domain in more detail and in a clinical context have not been adapted and translated into several languages, posing limitations to clinical practice and cross-language research. OBJECTIVES: The study aimed to (1) test the applicability of the Brazilian version of the Test for Reception of Grammar (TROG2-Br) to detect morphosyntactic deficits in patients with PPA; (2) investigate the association between performance in the test and sociodemographic and clinical variables (age, years of formal education, and disease duration); (3) characterize the performance of individuals presenting with the three more common variants of PPA (non-fluent, semantic, and logopenic) and mixed PPA (PPA-Mx) and analyze whether TROG-2 may assist in the distinction of these clinical profiles. METHODS: A total of 74 cognitively healthy participants and 34 individuals diagnosed with PPA were assessed with TROG2-Br. Overall scores (correct items, passed blocks), types, and categories of errors were analyzed. RESULTS: In controls, block scores were significantly correlated with years of formal education (Spearman's r = 0.33, p = 004) but not with age. In PPA, age, education, and disease duration were not significantly associated with performance in the test. Controls presented a significantly higher performance on TROG2-Br compared to PPA individuals and their errors pattern pointed to mild general cognitive processing difficulties (attention, working memory). PPA error types pointed to processing and morphosyntactic deficits in nonfluent or agrammatic PPA, (PPA-NF/A), logopenic PPA (PPA-L), and PPA-Mx. The semantic PPA (PPA-S) subgroup was qualitatively more similar to controls (processing difficulties and lower percentage of morphosyntactic errors). TROG2-Br presented good internal consistency and concurrent validity. DISCUSSION: Our results corroborate findings with TROG-2 in other populations. The performance of typical older adults with heterogeneous levels of education is discussed along with recommendations for clinical use of the test and future directions of research.
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spelling pubmed-91495942022-05-31 Sentence Comprehension in Primary Progressive Aphasia: A Study of the Application of the Brazilian Version of the Test for the Reception of Grammar (TROG2-Br) Carthery-Goulart, Maria Teresa de Oliveira, Rosimeire de Almeida, Isabel Junqueira Campanha, Aline da Silva Souza, Dayse Zana, Yossi Caramelli, Paulo Machado, Thais Helena Front Neurol Neurology Sentence-comprehension deficits have been described in patients with primary progressive aphasia (PPA). However, most instruments to address this domain in more detail and in a clinical context have not been adapted and translated into several languages, posing limitations to clinical practice and cross-language research. OBJECTIVES: The study aimed to (1) test the applicability of the Brazilian version of the Test for Reception of Grammar (TROG2-Br) to detect morphosyntactic deficits in patients with PPA; (2) investigate the association between performance in the test and sociodemographic and clinical variables (age, years of formal education, and disease duration); (3) characterize the performance of individuals presenting with the three more common variants of PPA (non-fluent, semantic, and logopenic) and mixed PPA (PPA-Mx) and analyze whether TROG-2 may assist in the distinction of these clinical profiles. METHODS: A total of 74 cognitively healthy participants and 34 individuals diagnosed with PPA were assessed with TROG2-Br. Overall scores (correct items, passed blocks), types, and categories of errors were analyzed. RESULTS: In controls, block scores were significantly correlated with years of formal education (Spearman's r = 0.33, p = 004) but not with age. In PPA, age, education, and disease duration were not significantly associated with performance in the test. Controls presented a significantly higher performance on TROG2-Br compared to PPA individuals and their errors pattern pointed to mild general cognitive processing difficulties (attention, working memory). PPA error types pointed to processing and morphosyntactic deficits in nonfluent or agrammatic PPA, (PPA-NF/A), logopenic PPA (PPA-L), and PPA-Mx. The semantic PPA (PPA-S) subgroup was qualitatively more similar to controls (processing difficulties and lower percentage of morphosyntactic errors). TROG2-Br presented good internal consistency and concurrent validity. DISCUSSION: Our results corroborate findings with TROG-2 in other populations. The performance of typical older adults with heterogeneous levels of education is discussed along with recommendations for clinical use of the test and future directions of research. Frontiers Media S.A. 2022-05-16 /pmc/articles/PMC9149594/ /pubmed/35651345 http://dx.doi.org/10.3389/fneur.2022.815227 Text en Copyright © 2022 Carthery-Goulart, de Oliveira, de Almeida, Campanha, da Silva Souza, Zana, Caramelli and Machado. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Carthery-Goulart, Maria Teresa
de Oliveira, Rosimeire
de Almeida, Isabel Junqueira
Campanha, Aline
da Silva Souza, Dayse
Zana, Yossi
Caramelli, Paulo
Machado, Thais Helena
Sentence Comprehension in Primary Progressive Aphasia: A Study of the Application of the Brazilian Version of the Test for the Reception of Grammar (TROG2-Br)
title Sentence Comprehension in Primary Progressive Aphasia: A Study of the Application of the Brazilian Version of the Test for the Reception of Grammar (TROG2-Br)
title_full Sentence Comprehension in Primary Progressive Aphasia: A Study of the Application of the Brazilian Version of the Test for the Reception of Grammar (TROG2-Br)
title_fullStr Sentence Comprehension in Primary Progressive Aphasia: A Study of the Application of the Brazilian Version of the Test for the Reception of Grammar (TROG2-Br)
title_full_unstemmed Sentence Comprehension in Primary Progressive Aphasia: A Study of the Application of the Brazilian Version of the Test for the Reception of Grammar (TROG2-Br)
title_short Sentence Comprehension in Primary Progressive Aphasia: A Study of the Application of the Brazilian Version of the Test for the Reception of Grammar (TROG2-Br)
title_sort sentence comprehension in primary progressive aphasia: a study of the application of the brazilian version of the test for the reception of grammar (trog2-br)
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9149594/
https://www.ncbi.nlm.nih.gov/pubmed/35651345
http://dx.doi.org/10.3389/fneur.2022.815227
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