In situ scarless skin healing of a severe human burn wound induced by a hCTLA4Ig gene-transferred porcine skin graft

Preventing fibrosis or hypertrophic scar formation following tissue damage is still a big challenge despite the numerous approaches clinicians currently use. Hitherto, no written account was available of a successful case of scarless skin healing after a severe burn injury. Here, we report the first...

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Autores principales: Zhang, Lijun, Xu, Guangchao, Wei, Yating, Yuan, Mingzhou, Li, Yuanyuan, Yin, Meifang, Chen, Chufen, Huang, Guangtao, Shu, Bin, Wu, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9149639/
https://www.ncbi.nlm.nih.gov/pubmed/35693752
http://dx.doi.org/10.7150/ijms.62438
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author Zhang, Lijun
Xu, Guangchao
Wei, Yating
Yuan, Mingzhou
Li, Yuanyuan
Yin, Meifang
Chen, Chufen
Huang, Guangtao
Shu, Bin
Wu, Jun
author_facet Zhang, Lijun
Xu, Guangchao
Wei, Yating
Yuan, Mingzhou
Li, Yuanyuan
Yin, Meifang
Chen, Chufen
Huang, Guangtao
Shu, Bin
Wu, Jun
author_sort Zhang, Lijun
collection PubMed
description Preventing fibrosis or hypertrophic scar formation following tissue damage is still a big challenge despite the numerous approaches clinicians currently use. Hitherto, no written account was available of a successful case of scarless skin healing after a severe burn injury. Here, we report the first case of the “perfect regenerative healing” of a severe burn wound with no hypertrophic scar formation in which a postage stamp skin autograft was covered with human cytotoxic-T-lymphocyte associated antigen4-immunoglobulin (hCTLA4Ig) gene-transferred pig skin. We also discuss the mechanisms involved in the scarless healing of human burn wounds.
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spelling pubmed-91496392022-06-10 In situ scarless skin healing of a severe human burn wound induced by a hCTLA4Ig gene-transferred porcine skin graft Zhang, Lijun Xu, Guangchao Wei, Yating Yuan, Mingzhou Li, Yuanyuan Yin, Meifang Chen, Chufen Huang, Guangtao Shu, Bin Wu, Jun Int J Med Sci Research Paper Preventing fibrosis or hypertrophic scar formation following tissue damage is still a big challenge despite the numerous approaches clinicians currently use. Hitherto, no written account was available of a successful case of scarless skin healing after a severe burn injury. Here, we report the first case of the “perfect regenerative healing” of a severe burn wound with no hypertrophic scar formation in which a postage stamp skin autograft was covered with human cytotoxic-T-lymphocyte associated antigen4-immunoglobulin (hCTLA4Ig) gene-transferred pig skin. We also discuss the mechanisms involved in the scarless healing of human burn wounds. Ivyspring International Publisher 2022-05-21 /pmc/articles/PMC9149639/ /pubmed/35693752 http://dx.doi.org/10.7150/ijms.62438 Text en © The author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Zhang, Lijun
Xu, Guangchao
Wei, Yating
Yuan, Mingzhou
Li, Yuanyuan
Yin, Meifang
Chen, Chufen
Huang, Guangtao
Shu, Bin
Wu, Jun
In situ scarless skin healing of a severe human burn wound induced by a hCTLA4Ig gene-transferred porcine skin graft
title In situ scarless skin healing of a severe human burn wound induced by a hCTLA4Ig gene-transferred porcine skin graft
title_full In situ scarless skin healing of a severe human burn wound induced by a hCTLA4Ig gene-transferred porcine skin graft
title_fullStr In situ scarless skin healing of a severe human burn wound induced by a hCTLA4Ig gene-transferred porcine skin graft
title_full_unstemmed In situ scarless skin healing of a severe human burn wound induced by a hCTLA4Ig gene-transferred porcine skin graft
title_short In situ scarless skin healing of a severe human burn wound induced by a hCTLA4Ig gene-transferred porcine skin graft
title_sort in situ scarless skin healing of a severe human burn wound induced by a hctla4ig gene-transferred porcine skin graft
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9149639/
https://www.ncbi.nlm.nih.gov/pubmed/35693752
http://dx.doi.org/10.7150/ijms.62438
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