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Functionalized Graphene Oxide with Chitosan for Dopamine Biosensing

Detecting biological structures via a rapid and facile method has become a pronounced point of research. Dopamine (DA) detection is critical for the early diagnosis of a variety of neurological diseases/disorders. A study on the real-time optical detection of DA is described here using graphene oxid...

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Detalles Bibliográficos
Autores principales: Omar, Amina, Bayoumy, Ahmed M., Aly, Ahmed A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9149961/
https://www.ncbi.nlm.nih.gov/pubmed/35645256
http://dx.doi.org/10.3390/jfb13020048
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author Omar, Amina
Bayoumy, Ahmed M.
Aly, Ahmed A.
author_facet Omar, Amina
Bayoumy, Ahmed M.
Aly, Ahmed A.
author_sort Omar, Amina
collection PubMed
description Detecting biological structures via a rapid and facile method has become a pronounced point of research. Dopamine (DA) detection is critical for the early diagnosis of a variety of neurological diseases/disorders. A study on the real-time optical detection of DA is described here using graphene oxide (GO) functionalized with chitosan (Cs). Hence, a computational model dependent on a high theoretical level density functional theory (DFT) using the B3LYP/LANL2DZ model is carried out to study the physical as well as electronic properties of the proposed interaction between GO functionalized with Cs and its interaction with DA. GO functionalized with a Cs biopolymer was verified as having much higher stability and reactivity. Moreover, the addition of DA to functionalized GO yields structures with the same stability and reactivity. This ensures that GO-Cs is a stable structure with a strong interaction with DA, which is energetically preferred. Molecular electrostatic potential (MESP) calculation maps indicated that the impact of an interaction between GO and Cs increases the number of electron clouds at the terminals, ensuring the great ability of this composite when interacting with DA. Hence, these calculations and experimental results support the feasibility of using GO functionalized with Cs as a DA biosensor.
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spelling pubmed-91499612022-05-31 Functionalized Graphene Oxide with Chitosan for Dopamine Biosensing Omar, Amina Bayoumy, Ahmed M. Aly, Ahmed A. J Funct Biomater Article Detecting biological structures via a rapid and facile method has become a pronounced point of research. Dopamine (DA) detection is critical for the early diagnosis of a variety of neurological diseases/disorders. A study on the real-time optical detection of DA is described here using graphene oxide (GO) functionalized with chitosan (Cs). Hence, a computational model dependent on a high theoretical level density functional theory (DFT) using the B3LYP/LANL2DZ model is carried out to study the physical as well as electronic properties of the proposed interaction between GO functionalized with Cs and its interaction with DA. GO functionalized with a Cs biopolymer was verified as having much higher stability and reactivity. Moreover, the addition of DA to functionalized GO yields structures with the same stability and reactivity. This ensures that GO-Cs is a stable structure with a strong interaction with DA, which is energetically preferred. Molecular electrostatic potential (MESP) calculation maps indicated that the impact of an interaction between GO and Cs increases the number of electron clouds at the terminals, ensuring the great ability of this composite when interacting with DA. Hence, these calculations and experimental results support the feasibility of using GO functionalized with Cs as a DA biosensor. MDPI 2022-04-27 /pmc/articles/PMC9149961/ /pubmed/35645256 http://dx.doi.org/10.3390/jfb13020048 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Omar, Amina
Bayoumy, Ahmed M.
Aly, Ahmed A.
Functionalized Graphene Oxide with Chitosan for Dopamine Biosensing
title Functionalized Graphene Oxide with Chitosan for Dopamine Biosensing
title_full Functionalized Graphene Oxide with Chitosan for Dopamine Biosensing
title_fullStr Functionalized Graphene Oxide with Chitosan for Dopamine Biosensing
title_full_unstemmed Functionalized Graphene Oxide with Chitosan for Dopamine Biosensing
title_short Functionalized Graphene Oxide with Chitosan for Dopamine Biosensing
title_sort functionalized graphene oxide with chitosan for dopamine biosensing
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9149961/
https://www.ncbi.nlm.nih.gov/pubmed/35645256
http://dx.doi.org/10.3390/jfb13020048
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