SARS-CoV-2 Omicron variant (B.1.1.529): A concern with immune escape

Omicron, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant that is now spreading across the world, is the most altered version to emerge so far, with mutations comparable to changes reported in earlier variants of concern linked with increased transmissibility and partial resi...

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Autores principales: Sanyaolu, Adekunle, Marinkovic, Aleksandra, Prakash, Stephanie, Haider, Nafees, Williams, Martina, Okorie, Chuku, Badaru, Olanrewaju, Smith, Stella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2022
Materias:
Minireviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9150026/
https://www.ncbi.nlm.nih.gov/pubmed/35665238
http://dx.doi.org/10.5501/wjv.v11.i3.137
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author Sanyaolu, Adekunle
Marinkovic, Aleksandra
Prakash, Stephanie
Haider, Nafees
Williams, Martina
Okorie, Chuku
Badaru, Olanrewaju
Smith, Stella
author_facet Sanyaolu, Adekunle
Marinkovic, Aleksandra
Prakash, Stephanie
Haider, Nafees
Williams, Martina
Okorie, Chuku
Badaru, Olanrewaju
Smith, Stella
author_sort Sanyaolu, Adekunle
collection PubMed
description Omicron, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant that is now spreading across the world, is the most altered version to emerge so far, with mutations comparable to changes reported in earlier variants of concern linked with increased transmissibility and partial resistance to vaccine-induced immunity. This article provides an overview of the SARS-CoV-2 variant Omicron (B.1.1.529) by reviewing the literature from major scientific databases. Although clear immunological and clinical data are not yet available, we extrapolated from what is known about mutations present in the Omicron variant of SARS-CoV-2 and offer preliminary indications on transmissibility, severity, and immune escape through existing research and databases.
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spelling pubmed-91500262022-06-04 SARS-CoV-2 Omicron variant (B.1.1.529): A concern with immune escape Sanyaolu, Adekunle Marinkovic, Aleksandra Prakash, Stephanie Haider, Nafees Williams, Martina Okorie, Chuku Badaru, Olanrewaju Smith, Stella World J Virol Minireviews Omicron, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant that is now spreading across the world, is the most altered version to emerge so far, with mutations comparable to changes reported in earlier variants of concern linked with increased transmissibility and partial resistance to vaccine-induced immunity. This article provides an overview of the SARS-CoV-2 variant Omicron (B.1.1.529) by reviewing the literature from major scientific databases. Although clear immunological and clinical data are not yet available, we extrapolated from what is known about mutations present in the Omicron variant of SARS-CoV-2 and offer preliminary indications on transmissibility, severity, and immune escape through existing research and databases. Baishideng Publishing Group Inc 2022-05-25 2022-05-25 /pmc/articles/PMC9150026/ /pubmed/35665238 http://dx.doi.org/10.5501/wjv.v11.i3.137 Text en ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Minireviews
Sanyaolu, Adekunle
Marinkovic, Aleksandra
Prakash, Stephanie
Haider, Nafees
Williams, Martina
Okorie, Chuku
Badaru, Olanrewaju
Smith, Stella
SARS-CoV-2 Omicron variant (B.1.1.529): A concern with immune escape
title SARS-CoV-2 Omicron variant (B.1.1.529): A concern with immune escape
title_full SARS-CoV-2 Omicron variant (B.1.1.529): A concern with immune escape
title_fullStr SARS-CoV-2 Omicron variant (B.1.1.529): A concern with immune escape
title_full_unstemmed SARS-CoV-2 Omicron variant (B.1.1.529): A concern with immune escape
title_short SARS-CoV-2 Omicron variant (B.1.1.529): A concern with immune escape
title_sort sars-cov-2 omicron variant (b.1.1.529): a concern with immune escape
topic Minireviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9150026/
https://www.ncbi.nlm.nih.gov/pubmed/35665238
http://dx.doi.org/10.5501/wjv.v11.i3.137
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