Reversible Monoacylglycerol Lipase Inhibitors: Discovery of a New Class of Benzylpiperidine Derivatives

[Image: see text] Monoacylglycerol lipase (MAGL) is the enzyme responsible for the metabolism of 2-arachidonoylglycerol in the brain and the hydrolysis of peripheral monoacylglycerols. Many studies demonstrated beneficial effects deriving from MAGL inhibition for neurodegenerative diseases, inflamma...

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Detalles Bibliográficos
Autores principales: Bononi, Giulia, Di Stefano, Miriana, Poli, Giulio, Ortore, Gabriella, Meier, Philip, Masetto, Francesca, Caligiuri, Isabella, Rizzolio, Flavio, Macchia, Marco, Chicca, Andrea, Avan, Amir, Giovannetti, Elisa, Vagaggini, Chiara, Brai, Annalaura, Dreassi, Elena, Valoti, Massimo, Minutolo, Filippo, Granchi, Carlotta, Gertsch, Jürg, Tuccinardi, Tiziano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9150076/
https://www.ncbi.nlm.nih.gov/pubmed/35522977
http://dx.doi.org/10.1021/acs.jmedchem.1c01806

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