Amyloid β Dodecamer Disrupts the Neuronal Membrane More Strongly than the Mature Fibril: Understanding the Role of Oligomers in Neurotoxicity

[Image: see text] The amyloid cascade hypothesis states that senile plaques, composed of amyloid β (Aβ) fibrils, play a key role in Alzheimer’s disease (AD). However, recent experiments have shown that Aβ oligomers are more toxic to neurons than highly ordered fibrils. The molecular mechanism underl...

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Detalles Bibliográficos
Autores principales: Nguyen, Hoang Linh, Linh, Huynh Quang, Krupa, Pawel, La Penna, Giovanni, Li, Mai Suan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9150093/
https://www.ncbi.nlm.nih.gov/pubmed/35580354
http://dx.doi.org/10.1021/acs.jpcb.2c01769

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9150093/
https://www.ncbi.nlm.nih.gov/pubmed/35580354
http://dx.doi.org/10.1021/acs.jpcb.2c01769

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