Highly Selective SERCA2a Activators: Preclinical Development of a Congeneric Group of First-in-Class Drug Leads against Heart Failure

[Image: see text] The stimulation of sarcoplasmic reticulum calcium ATPase SERCA2a emerged as a novel therapeutic strategy to efficiently improve overall cardiac function in heart failure (HF) with reduced arrhythmogenic risk. Istaroxime is a clinical-phase IIb compound with a double mechanism of ac...

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Detalles Bibliográficos
Autores principales: Luraghi, Andrea, Ferrandi, Mara, Barassi, Paolo, Arici, Martina, Hsu, Shih-Che, Torre, Eleonora, Ronchi, Carlotta, Romerio, Alessio, Chang, Gwo-Jyh, Ferrari, Patrizia, Bianchi, Giuseppe, Zaza, Antonio, Rocchetti, Marcella, Peri, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9150102/
https://www.ncbi.nlm.nih.gov/pubmed/35580334
http://dx.doi.org/10.1021/acs.jmedchem.2c00347

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