Phenyl Bis-Sulfonamide Keap1-Nrf2 Protein–Protein Interaction Inhibitors with an Alternative Binding Mode

[Image: see text] Inhibitors of Kelch-like ECH-associated protein 1 (Keap1) increase the activity of the transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) by stalling its ubiquitination and degradation. This enhances the expression of genes encoding proteins involved in drug de...

Descripción completa

Detalles Bibliográficos
Autores principales: Georgakopoulos, Nikolaos, Talapatra, Sandeep, Dikovskaya, Dina, Dayalan Naidu, Sharadha, Higgins, Maureen, Gatliff, Jemma, Ayhan, Aysel, Nikoloudaki, Roxani, Schaap, Marjolein, Valko, Klara, Javid, Farideh, Dinkova-Kostova, Albena T., Kozielski, Frank, Wells, Geoffrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9150106/
https://www.ncbi.nlm.nih.gov/pubmed/35549469
http://dx.doi.org/10.1021/acs.jmedchem.2c00457

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9150106/
https://www.ncbi.nlm.nih.gov/pubmed/35549469
http://dx.doi.org/10.1021/acs.jmedchem.2c00457

Ejemplares similares