The GBA1 D409V mutation exacerbates synuclein pathology to differing extents in two alpha-synuclein models

Heterozygous mutations in the GBA1 gene – encoding lysosomal glucocerebrosidase (GCase) – are the most common genetic risk factors for Parkinson's disease (PD). Experimental evidence suggests a correlation between decreased GCase activity and accumulation of alpha-synuclein (aSyn). To enable a...

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Detalles Bibliográficos
Autores principales: Polinski, Nicole K., Martinez, Terina N., Ramboz, Sylvie, Sasner, Michael, Herberth, Mark, Switzer, Robert, Ahmad, Syed O., Pelligrino, Lee J., Clark, Sean W., Marcus, Jacob N., Smith, Sean M., Dave, Kuldip D., Frasier, Mark A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9150115/
https://www.ncbi.nlm.nih.gov/pubmed/35419585
http://dx.doi.org/10.1242/dmm.049192

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9150115/
https://www.ncbi.nlm.nih.gov/pubmed/35419585
http://dx.doi.org/10.1242/dmm.049192

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