Tuning the Sensitivity of Genetically Encoded Fluorescent Potassium Indicators through Structure-Guided and Genome Mining Strategies

[Image: see text] Genetically encoded potassium indicators lack optimal binding affinity for monitoring intracellular dynamics in mammalian cells. Through structure-guided design and genome mining of potassium binding proteins, we developed green fluorescent potassium indicators with a broad range o...

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Detalles Bibliográficos
Autores principales: Torres Cabán, Cristina C., Yang, Minghan, Lai, Cuixin, Yang, Lina, Subach, Fedor V., Smith, Brian O., Piatkevich, Kiryl D., Boyden, Edward S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9150168/
https://www.ncbi.nlm.nih.gov/pubmed/35427452
http://dx.doi.org/10.1021/acssensors.1c02201

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9150168/
https://www.ncbi.nlm.nih.gov/pubmed/35427452
http://dx.doi.org/10.1021/acssensors.1c02201

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