Development of Geometry-Controlled All-Orthogonal BODIPY Trimers for Photodynamic Therapy and Phototheragnosis

[Image: see text] We have established an easy synthetic protocol for selectively developing all-orthogonal BODIPY trimers with unprecedented geometries on the basis of selecting methyl oxidation versus electrophilic formylation of key dimeric precursors. Photophysical characterization together with...

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Detalles Bibliográficos
Autores principales: Prieto-Castañeda, Alejandro, García-Garrido, Fernando, Díaz-Norambuena, Carolina, Escriche-Navarro, Blanca, García-Fernández, Alba, Bañuelos, Jorge, Rebollar, Esther, García-Moreno, Inmaculada, Martínez-Máñez, Ramón, de la Moya, Santiago, Agarrabeitia, Antonia R., Ortiz, María J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9150176/
https://www.ncbi.nlm.nih.gov/pubmed/35575720
http://dx.doi.org/10.1021/acs.orglett.2c01169
Descripción
Sumario:[Image: see text] We have established an easy synthetic protocol for selectively developing all-orthogonal BODIPY trimers with unprecedented geometries on the basis of selecting methyl oxidation versus electrophilic formylation of key dimeric precursors. Photophysical characterization together with biological assays unraveled the most suitable BODIPY–BODIPY geometrical arrangements within the trimer, forcing them to serve as molecular platforms for the development of new, advanced heavy-atom-free photosensitizers for photodynamic therapy and phototheragnosis.

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