Development of Geometry-Controlled All-Orthogonal BODIPY Trimers for Photodynamic Therapy and Phototheragnosis

[Image: see text] We have established an easy synthetic protocol for selectively developing all-orthogonal BODIPY trimers with unprecedented geometries on the basis of selecting methyl oxidation versus electrophilic formylation of key dimeric precursors. Photophysical characterization together with...

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Autores principales: Prieto-Castañeda, Alejandro, García-Garrido, Fernando, Díaz-Norambuena, Carolina, Escriche-Navarro, Blanca, García-Fernández, Alba, Bañuelos, Jorge, Rebollar, Esther, García-Moreno, Inmaculada, Martínez-Máñez, Ramón, de la Moya, Santiago, Agarrabeitia, Antonia R., Ortiz, María J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9150176/
https://www.ncbi.nlm.nih.gov/pubmed/35575720
http://dx.doi.org/10.1021/acs.orglett.2c01169
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author Prieto-Castañeda, Alejandro
García-Garrido, Fernando
Díaz-Norambuena, Carolina
Escriche-Navarro, Blanca
García-Fernández, Alba
Bañuelos, Jorge
Rebollar, Esther
García-Moreno, Inmaculada
Martínez-Máñez, Ramón
de la Moya, Santiago
Agarrabeitia, Antonia R.
Ortiz, María J.
author_facet Prieto-Castañeda, Alejandro
García-Garrido, Fernando
Díaz-Norambuena, Carolina
Escriche-Navarro, Blanca
García-Fernández, Alba
Bañuelos, Jorge
Rebollar, Esther
García-Moreno, Inmaculada
Martínez-Máñez, Ramón
de la Moya, Santiago
Agarrabeitia, Antonia R.
Ortiz, María J.
author_sort Prieto-Castañeda, Alejandro
collection PubMed
description [Image: see text] We have established an easy synthetic protocol for selectively developing all-orthogonal BODIPY trimers with unprecedented geometries on the basis of selecting methyl oxidation versus electrophilic formylation of key dimeric precursors. Photophysical characterization together with biological assays unraveled the most suitable BODIPY–BODIPY geometrical arrangements within the trimer, forcing them to serve as molecular platforms for the development of new, advanced heavy-atom-free photosensitizers for photodynamic therapy and phototheragnosis.
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spelling pubmed-91501762022-05-31 Development of Geometry-Controlled All-Orthogonal BODIPY Trimers for Photodynamic Therapy and Phototheragnosis Prieto-Castañeda, Alejandro García-Garrido, Fernando Díaz-Norambuena, Carolina Escriche-Navarro, Blanca García-Fernández, Alba Bañuelos, Jorge Rebollar, Esther García-Moreno, Inmaculada Martínez-Máñez, Ramón de la Moya, Santiago Agarrabeitia, Antonia R. Ortiz, María J. Org Lett [Image: see text] We have established an easy synthetic protocol for selectively developing all-orthogonal BODIPY trimers with unprecedented geometries on the basis of selecting methyl oxidation versus electrophilic formylation of key dimeric precursors. Photophysical characterization together with biological assays unraveled the most suitable BODIPY–BODIPY geometrical arrangements within the trimer, forcing them to serve as molecular platforms for the development of new, advanced heavy-atom-free photosensitizers for photodynamic therapy and phototheragnosis. American Chemical Society 2022-05-16 2022-05-27 /pmc/articles/PMC9150176/ /pubmed/35575720 http://dx.doi.org/10.1021/acs.orglett.2c01169 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Prieto-Castañeda, Alejandro
García-Garrido, Fernando
Díaz-Norambuena, Carolina
Escriche-Navarro, Blanca
García-Fernández, Alba
Bañuelos, Jorge
Rebollar, Esther
García-Moreno, Inmaculada
Martínez-Máñez, Ramón
de la Moya, Santiago
Agarrabeitia, Antonia R.
Ortiz, María J.
Development of Geometry-Controlled All-Orthogonal BODIPY Trimers for Photodynamic Therapy and Phototheragnosis
title Development of Geometry-Controlled All-Orthogonal BODIPY Trimers for Photodynamic Therapy and Phototheragnosis
title_full Development of Geometry-Controlled All-Orthogonal BODIPY Trimers for Photodynamic Therapy and Phototheragnosis
title_fullStr Development of Geometry-Controlled All-Orthogonal BODIPY Trimers for Photodynamic Therapy and Phototheragnosis
title_full_unstemmed Development of Geometry-Controlled All-Orthogonal BODIPY Trimers for Photodynamic Therapy and Phototheragnosis
title_short Development of Geometry-Controlled All-Orthogonal BODIPY Trimers for Photodynamic Therapy and Phototheragnosis
title_sort development of geometry-controlled all-orthogonal bodipy trimers for photodynamic therapy and phototheragnosis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9150176/
https://www.ncbi.nlm.nih.gov/pubmed/35575720
http://dx.doi.org/10.1021/acs.orglett.2c01169
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