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Laboratory biomarker predictors for disease progression and outcome among Egyptian COVID-19 patients
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic resulted in more than five hundred million infected cases worldwide. The current study aimed to screen the correlation of different laboratory findings with disease severity and clinical outcomes of coronavirus disease (COVID-...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9150244/ https://www.ncbi.nlm.nih.gov/pubmed/35622504 http://dx.doi.org/10.1177/03946320221096207 |
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author | Fathalla, Lamiaa A Kamal, Lamyaa M Salaheldin, Omina Khalil, Mahmoud A Kamel, Mahmoud M Fahim, Hagar H Abdel-Moneim, Youssef AS Abdulhakim, Jawaher A Abdel-Moneim, Ahmed S El-Meligui, Yomna M |
author_facet | Fathalla, Lamiaa A Kamal, Lamyaa M Salaheldin, Omina Khalil, Mahmoud A Kamel, Mahmoud M Fahim, Hagar H Abdel-Moneim, Youssef AS Abdulhakim, Jawaher A Abdel-Moneim, Ahmed S El-Meligui, Yomna M |
author_sort | Fathalla, Lamiaa A |
collection | PubMed |
description | The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic resulted in more than five hundred million infected cases worldwide. The current study aimed to screen the correlation of different laboratory findings with disease severity and clinical outcomes of coronavirus disease (COVID-19) among Egyptian patients to obtain prognostic indicators of disease severity and outcome. A total of 112 laboratory-confirmed COVID-19 patients were examined. According to the severity of the disease, these patients were divided into three main groups: mild, moderate and severe cases. In addition, clinical characteristics and laboratory findings, including Hb, platelet count, white blood cell count, lymphocyte percentage, neutrophil percentage, neutrophil lymphocyte ratio (NLR), D-dimer, highly sensitive C-reactive protein (HS-CRP), alanine aminotransferase (ALT), lactate dehydrogenase (LDH) and creatinine, were measured. The presence of hypertension and/or diabetes was found to be a significant risk factor for disease severity and poor outcome. Increased respiratory rate, levels of SpO(2), HS-CRP, D-dimer, NLR, ALT, LDH, lymphopenia and neutrophilia, as well as changes in chest computed tomography (CT), were associated with increased disease severity and fatal consequences. Highly sensitive C-reactive protein, D-dimer, NLR and LDH constituted excellent predictors for both disease severity and death. Laboratory biomarkers, such as HS-CRP, D-dimer, NLR and LDH, are excellent predictors for both disease severity and death. They can predict mortality in patients at the time of admission secondary to SARS-CoV-2 infection and can help physicians identify high-risk patients before clinical deterioration. |
format | Online Article Text |
id | pubmed-9150244 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-91502442022-05-31 Laboratory biomarker predictors for disease progression and outcome among Egyptian COVID-19 patients Fathalla, Lamiaa A Kamal, Lamyaa M Salaheldin, Omina Khalil, Mahmoud A Kamel, Mahmoud M Fahim, Hagar H Abdel-Moneim, Youssef AS Abdulhakim, Jawaher A Abdel-Moneim, Ahmed S El-Meligui, Yomna M Int J Immunopathol Pharmacol Inflammatory Mediators in COVID-19 and Other Diseases - Original Research Article The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic resulted in more than five hundred million infected cases worldwide. The current study aimed to screen the correlation of different laboratory findings with disease severity and clinical outcomes of coronavirus disease (COVID-19) among Egyptian patients to obtain prognostic indicators of disease severity and outcome. A total of 112 laboratory-confirmed COVID-19 patients were examined. According to the severity of the disease, these patients were divided into three main groups: mild, moderate and severe cases. In addition, clinical characteristics and laboratory findings, including Hb, platelet count, white blood cell count, lymphocyte percentage, neutrophil percentage, neutrophil lymphocyte ratio (NLR), D-dimer, highly sensitive C-reactive protein (HS-CRP), alanine aminotransferase (ALT), lactate dehydrogenase (LDH) and creatinine, were measured. The presence of hypertension and/or diabetes was found to be a significant risk factor for disease severity and poor outcome. Increased respiratory rate, levels of SpO(2), HS-CRP, D-dimer, NLR, ALT, LDH, lymphopenia and neutrophilia, as well as changes in chest computed tomography (CT), were associated with increased disease severity and fatal consequences. Highly sensitive C-reactive protein, D-dimer, NLR and LDH constituted excellent predictors for both disease severity and death. Laboratory biomarkers, such as HS-CRP, D-dimer, NLR and LDH, are excellent predictors for both disease severity and death. They can predict mortality in patients at the time of admission secondary to SARS-CoV-2 infection and can help physicians identify high-risk patients before clinical deterioration. SAGE Publications 2022-05-27 /pmc/articles/PMC9150244/ /pubmed/35622504 http://dx.doi.org/10.1177/03946320221096207 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Inflammatory Mediators in COVID-19 and Other Diseases - Original Research Article Fathalla, Lamiaa A Kamal, Lamyaa M Salaheldin, Omina Khalil, Mahmoud A Kamel, Mahmoud M Fahim, Hagar H Abdel-Moneim, Youssef AS Abdulhakim, Jawaher A Abdel-Moneim, Ahmed S El-Meligui, Yomna M Laboratory biomarker predictors for disease progression and outcome among Egyptian COVID-19 patients |
title | Laboratory biomarker predictors for disease progression and outcome among Egyptian COVID-19 patients |
title_full | Laboratory biomarker predictors for disease progression and outcome among Egyptian COVID-19 patients |
title_fullStr | Laboratory biomarker predictors for disease progression and outcome among Egyptian COVID-19 patients |
title_full_unstemmed | Laboratory biomarker predictors for disease progression and outcome among Egyptian COVID-19 patients |
title_short | Laboratory biomarker predictors for disease progression and outcome among Egyptian COVID-19 patients |
title_sort | laboratory biomarker predictors for disease progression and outcome among egyptian covid-19 patients |
topic | Inflammatory Mediators in COVID-19 and Other Diseases - Original Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9150244/ https://www.ncbi.nlm.nih.gov/pubmed/35622504 http://dx.doi.org/10.1177/03946320221096207 |
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