RRM2 Mediates the Anti-Tumor Effect of the Natural Product Pectolinarigenin on Glioblastoma Through Promoting CDK1 Protein Degradation by Increasing Autophagic Flux

The natural product pectolinarigenin exerts anti-inflammatory activity and anti-tumor effects, and exhibits different biological functions, particularly in autophagy and cell cycle regulation. However, the antineoplastic effect of pectolinarigenin on glioblastoma (GBM) remains unclear. In the presen...

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Detalles Bibliográficos
Autores principales: Jiang, Haiping, Zhang, Dongzhi, Aleksandrovich, Karpov Denis, Ye, Junyi, Wang, Lixiang, Chen, Xiaofeng, Gao, Ming, Wang, Xinzhuang, Yan, Tao, Yang, He, Lu, Enzhou, Liu, Wenwu, Zhang, Cheng, Wu, Jianing, Yao, Penglei, Sun, Zhenying, Rong, Xuan, Timofeevich, Sokhatskii Andrei, Mahmutovich, Safin Shamil, Zheng, Zhixing, Chen, Xin, Zhao, Shiguang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9150261/
https://www.ncbi.nlm.nih.gov/pubmed/35651787
http://dx.doi.org/10.3389/fonc.2022.887294

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