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Knockdown of PAR2 alleviates cancer-induced bone pain by inhibiting the activation of astrocytes and the ERK pathway

OBJECTIVE: Cancer-induced bone pain (CIBP) is a kind of pain with complex pathophysiology. Proteinase-activated receptor 2 (PAR-2) is involved in CIBP. This study explored the effects of PAR-2 on CIBP rats. METHODS: CIBP rat model was established by injecting Walker 256 rat breast cancer cells into...

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Detalles Bibliográficos
Autores principales:	Tang, Yiting, Chen, Yupeng, Yang, Mingzhu, Zheng, Qiuhui, Li, Yaoyuan, Bao, Yanju
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9150294/ https://www.ncbi.nlm.nih.gov/pubmed/35637468 http://dx.doi.org/10.1186/s12891-022-05312-x

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