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Subsequent treatments beyond progression on osimertinib in EGFR-mutated NSCLC and leptomeningeal metastases

BACKGROUND: Despite the reported efficacy of osimertinib, central nervous system (CNS) progression is still frequent in EGFR-mutated NSCLC. This study aimed to reveal site-specific resistant mechanisms to osimertinib and investigate subsequent treatments for leptomeningeal metastases (LM). METHODS:...

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Detalles Bibliográficos
Autores principales:	Zheng, Mei-Mei, Li, Yang-Si, Tu, Hai-Yan, Sun, Hao, Yin, Kai, Jiang, Ben-Yuan, Yang, Jin-Ji, Zhang, Xu-Chao, Zhou, Qing, Xu, Chong-Rui, Wang, Zhen, Chen, Hua-Jun, Zhou, De-Xiang, Wu, Yi-Long
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9150343/ https://www.ncbi.nlm.nih.gov/pubmed/35644609 http://dx.doi.org/10.1186/s12916-022-02387-0

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