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The Saturation Effect of Obesity on Bone Mineral Density for Older People: The NHANES 2017–2020

INTRODUCTION: Previous studies have shown that obesity has a positive effect on bone mineral density (BMD). However, excessive obesity is harmful to health, especially in older adults. In addition, it is unclear what body mass index (BMI) and waist circumference (WC) to maintain for the most benefic...

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Autores principales: Zhang, Ya, Pu, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9150366/
https://www.ncbi.nlm.nih.gov/pubmed/35651972
http://dx.doi.org/10.3389/fendo.2022.883862
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author Zhang, Ya
Pu, Jian
author_facet Zhang, Ya
Pu, Jian
author_sort Zhang, Ya
collection PubMed
description INTRODUCTION: Previous studies have shown that obesity has a positive effect on bone mineral density (BMD). However, excessive obesity is harmful to health, especially in older adults. In addition, it is unclear what body mass index (BMI) and waist circumference (WC) to maintain for the most beneficial BMD in older adults. METHODS: Multivariate logistic regression models were used to investigate the association between BMI, WC, and femoral neck BMD using the most recent data from the 2017–2020 National Health and Nutrition Examination Survey (NHANES). Fitting smoothing curves and saturation effects analysis were also used to determine the association of nonlinear relationships between BMI, WC, and femoral neck BMD. RESULTS: The analysis included a total of 2,903 adults. We discovered that BMD and WC were positively linked to femoral neck BMD. The favorable associations of BMI and WC with femoral neck BMD were maintained in all subgroup analyses stratified by sex and race, except among Mexican Americans. Furthermore, smoothing curve fitting revealed that the link between BMI and BMD was not only a linear connection, and that there was a saturation point. The BMI saturation value in the femoral neck BMD was 24.3 (kg/m(2)), according to the saturation effect analysis. CONCLUSIONS: In persons over the age of 50, our research found a positive relationship between obesity and BMD, and we also found a saturation value between BMI and BMD. According to this study, maintaining BMI at a moderate level (about 24.3 kg/m(2)) would result in an optimal balance between BMI and BMD in adults over 50 years of age.
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spelling pubmed-91503662022-05-31 The Saturation Effect of Obesity on Bone Mineral Density for Older People: The NHANES 2017–2020 Zhang, Ya Pu, Jian Front Endocrinol (Lausanne) Endocrinology INTRODUCTION: Previous studies have shown that obesity has a positive effect on bone mineral density (BMD). However, excessive obesity is harmful to health, especially in older adults. In addition, it is unclear what body mass index (BMI) and waist circumference (WC) to maintain for the most beneficial BMD in older adults. METHODS: Multivariate logistic regression models were used to investigate the association between BMI, WC, and femoral neck BMD using the most recent data from the 2017–2020 National Health and Nutrition Examination Survey (NHANES). Fitting smoothing curves and saturation effects analysis were also used to determine the association of nonlinear relationships between BMI, WC, and femoral neck BMD. RESULTS: The analysis included a total of 2,903 adults. We discovered that BMD and WC were positively linked to femoral neck BMD. The favorable associations of BMI and WC with femoral neck BMD were maintained in all subgroup analyses stratified by sex and race, except among Mexican Americans. Furthermore, smoothing curve fitting revealed that the link between BMI and BMD was not only a linear connection, and that there was a saturation point. The BMI saturation value in the femoral neck BMD was 24.3 (kg/m(2)), according to the saturation effect analysis. CONCLUSIONS: In persons over the age of 50, our research found a positive relationship between obesity and BMD, and we also found a saturation value between BMI and BMD. According to this study, maintaining BMI at a moderate level (about 24.3 kg/m(2)) would result in an optimal balance between BMI and BMD in adults over 50 years of age. Frontiers Media S.A. 2022-05-16 /pmc/articles/PMC9150366/ /pubmed/35651972 http://dx.doi.org/10.3389/fendo.2022.883862 Text en Copyright © 2022 Zhang and Pu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Zhang, Ya
Pu, Jian
The Saturation Effect of Obesity on Bone Mineral Density for Older People: The NHANES 2017–2020
title The Saturation Effect of Obesity on Bone Mineral Density for Older People: The NHANES 2017–2020
title_full The Saturation Effect of Obesity on Bone Mineral Density for Older People: The NHANES 2017–2020
title_fullStr The Saturation Effect of Obesity on Bone Mineral Density for Older People: The NHANES 2017–2020
title_full_unstemmed The Saturation Effect of Obesity on Bone Mineral Density for Older People: The NHANES 2017–2020
title_short The Saturation Effect of Obesity on Bone Mineral Density for Older People: The NHANES 2017–2020
title_sort saturation effect of obesity on bone mineral density for older people: the nhanes 2017–2020
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9150366/
https://www.ncbi.nlm.nih.gov/pubmed/35651972
http://dx.doi.org/10.3389/fendo.2022.883862
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