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Non-alcoholic Fatty Liver Disease Is Associated With Aortic Calcification: A Cohort Study With Propensity Score Matching

OBJECTIVES: Non-alcoholic fatty liver disease (NAFLD) greatly affects cardiovascular disease, but evidence on the associations between NAFLD and markers of aortic calcification is limited. We aim to evaluate the association between NAFLD and aortic calcification in a cohort of Chinese adults using p...

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Autores principales: Zhu, Rong-Rong, Gao, Xu-Ping, Liao, Min-Qi, Cui, Yun-Feng, Tan, Si-Xian, Zeng, Fang-Fang, Lou, Yan-Mei, Wang, Chang-Yi, Xu, Shan, Peng, Xiao-Lin, Dai, Shu-Hong, Zhao, Dan, Wang, Li, Ping, Zhao, Dai, Xiao-Yu, Feng, Pin-Ning, Han, Li-Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9150367/
https://www.ncbi.nlm.nih.gov/pubmed/35651978
http://dx.doi.org/10.3389/fendo.2022.880683
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author Zhu, Rong-Rong
Gao, Xu-Ping
Liao, Min-Qi
Cui, Yun-Feng
Tan, Si-Xian
Zeng, Fang-Fang
Lou, Yan-Mei
Wang, Chang-Yi
Xu, Shan
Peng, Xiao-Lin
Dai, Shu-Hong
Zhao, Dan
Wang, Li
Ping, Zhao
Dai, Xiao-Yu
Feng, Pin-Ning
Han, Li-Yuan
author_facet Zhu, Rong-Rong
Gao, Xu-Ping
Liao, Min-Qi
Cui, Yun-Feng
Tan, Si-Xian
Zeng, Fang-Fang
Lou, Yan-Mei
Wang, Chang-Yi
Xu, Shan
Peng, Xiao-Lin
Dai, Shu-Hong
Zhao, Dan
Wang, Li
Ping, Zhao
Dai, Xiao-Yu
Feng, Pin-Ning
Han, Li-Yuan
author_sort Zhu, Rong-Rong
collection PubMed
description OBJECTIVES: Non-alcoholic fatty liver disease (NAFLD) greatly affects cardiovascular disease, but evidence on the associations between NAFLD and markers of aortic calcification is limited. We aim to evaluate the association between NAFLD and aortic calcification in a cohort of Chinese adults using propensity score-matching (PSM) analysis. METHODS: This prospective cohort study involved adults who underwent health-screening examinations from 2009 to 2016. NAFLD was diagnosed by abdominal ultrasonography at baseline, and aortic calcification was identified using a VCT LightSpeed 64 scanner. Analyses included Cox proportional-hazards regression analysis and PSM with predefined covariates (age, gender, marital and smoking status, and use of lipid-lowering drugs) to achieve a 1:1 balanced cohort. RESULTS: Of the 6,047 eligible participants, 2,729 (45.13%) were diagnosed with NAFLD at baseline, with a median age of 49.0 years [interquartile range, 44.0–55.0]. We selected 2,339 pairs of participants with and without NAFLD at baseline for the PSM subpopulation. Compared with those without NAFLD, patients with NAFLD were at a higher risk of developing aortic calcification during follow-up; significant results were observed before and after matching, with the full-adjusted hazard ratios and corresponding 95% confidence intervals being 1.19 (1.02–1.38) and 1.18 (1.01–1.38), respectively (both p < 0.05). In subgroup analyses, no interaction was detected according to age, gender, smoking status, body mass index, total cholesterol, low-density lipoprotein cholesterol, use of lipid-lowering drugs, hypertension, or type 2 diabetes. CONCLUSIONS: NAFLD may be independently associated with aortic calcification. Further studies are warranted to elucidate the possible underlying mechanisms.
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spelling pubmed-91503672022-05-31 Non-alcoholic Fatty Liver Disease Is Associated With Aortic Calcification: A Cohort Study With Propensity Score Matching Zhu, Rong-Rong Gao, Xu-Ping Liao, Min-Qi Cui, Yun-Feng Tan, Si-Xian Zeng, Fang-Fang Lou, Yan-Mei Wang, Chang-Yi Xu, Shan Peng, Xiao-Lin Dai, Shu-Hong Zhao, Dan Wang, Li Ping, Zhao Dai, Xiao-Yu Feng, Pin-Ning Han, Li-Yuan Front Endocrinol (Lausanne) Endocrinology OBJECTIVES: Non-alcoholic fatty liver disease (NAFLD) greatly affects cardiovascular disease, but evidence on the associations between NAFLD and markers of aortic calcification is limited. We aim to evaluate the association between NAFLD and aortic calcification in a cohort of Chinese adults using propensity score-matching (PSM) analysis. METHODS: This prospective cohort study involved adults who underwent health-screening examinations from 2009 to 2016. NAFLD was diagnosed by abdominal ultrasonography at baseline, and aortic calcification was identified using a VCT LightSpeed 64 scanner. Analyses included Cox proportional-hazards regression analysis and PSM with predefined covariates (age, gender, marital and smoking status, and use of lipid-lowering drugs) to achieve a 1:1 balanced cohort. RESULTS: Of the 6,047 eligible participants, 2,729 (45.13%) were diagnosed with NAFLD at baseline, with a median age of 49.0 years [interquartile range, 44.0–55.0]. We selected 2,339 pairs of participants with and without NAFLD at baseline for the PSM subpopulation. Compared with those without NAFLD, patients with NAFLD were at a higher risk of developing aortic calcification during follow-up; significant results were observed before and after matching, with the full-adjusted hazard ratios and corresponding 95% confidence intervals being 1.19 (1.02–1.38) and 1.18 (1.01–1.38), respectively (both p < 0.05). In subgroup analyses, no interaction was detected according to age, gender, smoking status, body mass index, total cholesterol, low-density lipoprotein cholesterol, use of lipid-lowering drugs, hypertension, or type 2 diabetes. CONCLUSIONS: NAFLD may be independently associated with aortic calcification. Further studies are warranted to elucidate the possible underlying mechanisms. Frontiers Media S.A. 2022-05-16 /pmc/articles/PMC9150367/ /pubmed/35651978 http://dx.doi.org/10.3389/fendo.2022.880683 Text en Copyright © 2022 Zhu, Gao, Liao, Cui, Tan, Zeng, Lou, Wang, Xu, Peng, Dai, Zhao, Wang, Ping, Dai, Feng and Han https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Zhu, Rong-Rong
Gao, Xu-Ping
Liao, Min-Qi
Cui, Yun-Feng
Tan, Si-Xian
Zeng, Fang-Fang
Lou, Yan-Mei
Wang, Chang-Yi
Xu, Shan
Peng, Xiao-Lin
Dai, Shu-Hong
Zhao, Dan
Wang, Li
Ping, Zhao
Dai, Xiao-Yu
Feng, Pin-Ning
Han, Li-Yuan
Non-alcoholic Fatty Liver Disease Is Associated With Aortic Calcification: A Cohort Study With Propensity Score Matching
title Non-alcoholic Fatty Liver Disease Is Associated With Aortic Calcification: A Cohort Study With Propensity Score Matching
title_full Non-alcoholic Fatty Liver Disease Is Associated With Aortic Calcification: A Cohort Study With Propensity Score Matching
title_fullStr Non-alcoholic Fatty Liver Disease Is Associated With Aortic Calcification: A Cohort Study With Propensity Score Matching
title_full_unstemmed Non-alcoholic Fatty Liver Disease Is Associated With Aortic Calcification: A Cohort Study With Propensity Score Matching
title_short Non-alcoholic Fatty Liver Disease Is Associated With Aortic Calcification: A Cohort Study With Propensity Score Matching
title_sort non-alcoholic fatty liver disease is associated with aortic calcification: a cohort study with propensity score matching
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9150367/
https://www.ncbi.nlm.nih.gov/pubmed/35651978
http://dx.doi.org/10.3389/fendo.2022.880683
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