Constitutive loss of DNMT3A causes morbid obesity through misregulation of adipogenesis

DNA Methyltransferase 3 A (DNMT3A) is an important facilitator of differentiation of both embryonic and hematopoietic stem cells. Heterozygous germline mutations in DNMT3A lead to Tatton-Brown-Rahman Syndrome (TBRS), characterized by obesity and excessive height. While DNMT3A is known to impact feed...

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Detalles Bibliográficos
Autores principales: Tovy, Ayala, Reyes, Jaime M, Zhang, Linda, Huang, Yung-Hsin, Rosas, Carina, Daquinag, Alexes C, Guzman, Anna, Ramabadran, Raghav, Chen, Chun-Wei, Gu, Tianpeng, Gupta, Sinjini, Ortinau, Laura, Park, Dongsu, Cox, Aaron R, Rau, Rachel E, Hartig, Sean M, Kolonin, Mikhail G, Goodell, Margaret A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9150890/
https://www.ncbi.nlm.nih.gov/pubmed/35635747
http://dx.doi.org/10.7554/eLife.72359

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