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Imaging of the pial arterial vasculature of the human brain in vivo using high-resolution 7T time-of-flight angiography
The pial arterial vasculature of the human brain is the only blood supply to the neocortex, but quantitative data on the morphology and topology of these mesoscopic arteries (diameter 50–300 µm) remains scarce. Because it is commonly assumed that blood flow velocities in these vessels are prohibitiv...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9150892/ https://www.ncbi.nlm.nih.gov/pubmed/35486089 http://dx.doi.org/10.7554/eLife.71186 |
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author | Bollmann, Saskia Mattern, Hendrik Bernier, Michaël Robinson, Simon D Park, Daniel Speck, Oliver Polimeni, Jonathan R |
author_facet | Bollmann, Saskia Mattern, Hendrik Bernier, Michaël Robinson, Simon D Park, Daniel Speck, Oliver Polimeni, Jonathan R |
author_sort | Bollmann, Saskia |
collection | PubMed |
description | The pial arterial vasculature of the human brain is the only blood supply to the neocortex, but quantitative data on the morphology and topology of these mesoscopic arteries (diameter 50–300 µm) remains scarce. Because it is commonly assumed that blood flow velocities in these vessels are prohibitively slow, non-invasive time-of-flight magnetic resonance angiography (TOF-MRA)—which is well suited to high 3D imaging resolutions—has not been applied to imaging the pial arteries. Here, we provide a theoretical framework that outlines how TOF-MRA can visualize small pial arteries in vivo, by employing extremely small voxels at the size of individual vessels. We then provide evidence for this theory by imaging the pial arteries at 140 µm isotropic resolution using a 7 Tesla (T) magnetic resonance imaging (MRI) scanner and prospective motion correction, and show that pial arteries one voxel width in diameter can be detected. We conclude that imaging pial arteries is not limited by slow blood flow, but instead by achievable image resolution. This study represents the first targeted, comprehensive account of imaging pial arteries in vivo in the human brain. This ultra-high-resolution angiography will enable the characterization of pial vascular anatomy across the brain to investigate patterns of blood supply and relationships between vascular and functional architecture. |
format | Online Article Text |
id | pubmed-9150892 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-91508922022-05-31 Imaging of the pial arterial vasculature of the human brain in vivo using high-resolution 7T time-of-flight angiography Bollmann, Saskia Mattern, Hendrik Bernier, Michaël Robinson, Simon D Park, Daniel Speck, Oliver Polimeni, Jonathan R eLife Neuroscience The pial arterial vasculature of the human brain is the only blood supply to the neocortex, but quantitative data on the morphology and topology of these mesoscopic arteries (diameter 50–300 µm) remains scarce. Because it is commonly assumed that blood flow velocities in these vessels are prohibitively slow, non-invasive time-of-flight magnetic resonance angiography (TOF-MRA)—which is well suited to high 3D imaging resolutions—has not been applied to imaging the pial arteries. Here, we provide a theoretical framework that outlines how TOF-MRA can visualize small pial arteries in vivo, by employing extremely small voxels at the size of individual vessels. We then provide evidence for this theory by imaging the pial arteries at 140 µm isotropic resolution using a 7 Tesla (T) magnetic resonance imaging (MRI) scanner and prospective motion correction, and show that pial arteries one voxel width in diameter can be detected. We conclude that imaging pial arteries is not limited by slow blood flow, but instead by achievable image resolution. This study represents the first targeted, comprehensive account of imaging pial arteries in vivo in the human brain. This ultra-high-resolution angiography will enable the characterization of pial vascular anatomy across the brain to investigate patterns of blood supply and relationships between vascular and functional architecture. eLife Sciences Publications, Ltd 2022-04-29 /pmc/articles/PMC9150892/ /pubmed/35486089 http://dx.doi.org/10.7554/eLife.71186 Text en © 2022, Bollmann et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Neuroscience Bollmann, Saskia Mattern, Hendrik Bernier, Michaël Robinson, Simon D Park, Daniel Speck, Oliver Polimeni, Jonathan R Imaging of the pial arterial vasculature of the human brain in vivo using high-resolution 7T time-of-flight angiography |
title | Imaging of the pial arterial vasculature of the human brain in vivo using high-resolution 7T time-of-flight angiography |
title_full | Imaging of the pial arterial vasculature of the human brain in vivo using high-resolution 7T time-of-flight angiography |
title_fullStr | Imaging of the pial arterial vasculature of the human brain in vivo using high-resolution 7T time-of-flight angiography |
title_full_unstemmed | Imaging of the pial arterial vasculature of the human brain in vivo using high-resolution 7T time-of-flight angiography |
title_short | Imaging of the pial arterial vasculature of the human brain in vivo using high-resolution 7T time-of-flight angiography |
title_sort | imaging of the pial arterial vasculature of the human brain in vivo using high-resolution 7t time-of-flight angiography |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9150892/ https://www.ncbi.nlm.nih.gov/pubmed/35486089 http://dx.doi.org/10.7554/eLife.71186 |
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