Implementation of CYP2D6 copy-number imputation panel and frequency of key pharmacogenetic variants in Finnish individuals with a psychotic disorder

We demonstrate that CYP2D6 copy-number variation (CNV) can be imputed using existing imputation algorithms. Additionally, we report frequencies of key pharmacogenetic variants in individuals with a psychotic disorder from the genetically bottle-necked population of Finland. We combined GWAS chip and...

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Autores principales: Häkkinen, Katja, Kiiski, Johanna I., Lähteenvuo, Markku, Jukuri, Tuomas, Suokas, Kimmo, Niemi-Pynttäri, Jussi, Kieseppä, Tuula, Männynsalo, Teemu, Wegelius, Asko, Haaki, Willehard, Lahdensuo, Kaisla, Kajanne, Risto, Kaunisto, Mari A., Tuulio-Henriksson, Annamari, Kampman, Olli, Hietala, Jarmo, Veijola, Juha, Lönnqvist, Jouko, Isometsä, Erkki, Paunio, Tiina, Suvisaari, Jaana, Kalso, Eija, Niemi, Mikko, Tiihonen, Jari, Daly, Mark, Palotie, Aarno, Ahola-Olli, Ari V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9151384/
https://www.ncbi.nlm.nih.gov/pubmed/35197553
http://dx.doi.org/10.1038/s41397-022-00270-y

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