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Effect of diet change in healthy dogs with subclinical cardiac biomarker or echocardiographic abnormalities
BACKGROUND: A recent study showed higher high‐sensitivity cardiac troponin I (hs‐cTnI) concentrations in healthy dogs eating grain‐free (GF) compared to those eating grain‐inclusive (GI) diets. HYPOTHESIS/OBJECTIVES: Healthy dogs with subclinical cardiac abnormalities eating GF diets at baseline wil...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9151466/ https://www.ncbi.nlm.nih.gov/pubmed/35420218 http://dx.doi.org/10.1111/jvim.16416 |
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author | Haimovitz, Dana Vereb, Michelle Freeman, Lisa Goldberg, Robert Lessard, Darleen Rush, John Adin, Darcy |
author_facet | Haimovitz, Dana Vereb, Michelle Freeman, Lisa Goldberg, Robert Lessard, Darleen Rush, John Adin, Darcy |
author_sort | Haimovitz, Dana |
collection | PubMed |
description | BACKGROUND: A recent study showed higher high‐sensitivity cardiac troponin I (hs‐cTnI) concentrations in healthy dogs eating grain‐free (GF) compared to those eating grain‐inclusive (GI) diets. HYPOTHESIS/OBJECTIVES: Healthy dogs with subclinical cardiac abnormalities eating GF diets at baseline will show improvements in cardiac biomarkers and echocardiographic variables after diet change, whereas healthy dogs eating GI diets at baseline will not improve. ANIMALS: Twenty healthy dogs with subclinical cardiac abnormalities (12 Golden Retrievers, 5 Doberman Pinschers, 3 Miniature Schnauzers). METHODS: This prospective study included dogs with increased hs‐cTnI or N‐terminal pro‐B‐type natriuretic peptide (NT‐proBNP) concentrations, or echocardiographic abnormalities. Mixed modeling was used to evaluate echocardiographic, hs‐cTnI, and NT‐proBNP differences between groups (GF or GI diet at baseline) over time (1 y after diet change). RESULTS: Ten GF and 10 GI dogs were evaluated. There were statistically significant time: group interactions for hs‐cTnI (P = .02) and normalized left ventricular internal systolic diameter (LVIDsN; P = .02), with GF dogs showing larger decreases in these variables than GI dogs. Median (range) hs‐cTnI (ng/mL) for GF dogs was 0.141 (0.012‐0.224) at baseline and 0.092 (0.044‐0.137) at 1 y, and for GI dogs was 0.051 (0.016‐0.195) at baseline and 0.060 (0.022‐0.280) at 1 y. Median LVIDsN for GF dogs was 1.01 (0.70‐1.30) at baseline and 0.87 (0.79‐1.24) at 1 y, and for GI dogs was 1.05 (0.84‐1.21) at baseline and 1.10 (0.85‐1.28) at 1 y. CONCLUSIONS AND CLINICAL IMPORTANCE: Decreased hs‐cTnI and LVIDsN in GF dogs after diet change supports reversibility of these subclinical myocardial abnormalities. |
format | Online Article Text |
id | pubmed-9151466 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley & Sons, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-91514662022-06-04 Effect of diet change in healthy dogs with subclinical cardiac biomarker or echocardiographic abnormalities Haimovitz, Dana Vereb, Michelle Freeman, Lisa Goldberg, Robert Lessard, Darleen Rush, John Adin, Darcy J Vet Intern Med SMALL ANIMAL BACKGROUND: A recent study showed higher high‐sensitivity cardiac troponin I (hs‐cTnI) concentrations in healthy dogs eating grain‐free (GF) compared to those eating grain‐inclusive (GI) diets. HYPOTHESIS/OBJECTIVES: Healthy dogs with subclinical cardiac abnormalities eating GF diets at baseline will show improvements in cardiac biomarkers and echocardiographic variables after diet change, whereas healthy dogs eating GI diets at baseline will not improve. ANIMALS: Twenty healthy dogs with subclinical cardiac abnormalities (12 Golden Retrievers, 5 Doberman Pinschers, 3 Miniature Schnauzers). METHODS: This prospective study included dogs with increased hs‐cTnI or N‐terminal pro‐B‐type natriuretic peptide (NT‐proBNP) concentrations, or echocardiographic abnormalities. Mixed modeling was used to evaluate echocardiographic, hs‐cTnI, and NT‐proBNP differences between groups (GF or GI diet at baseline) over time (1 y after diet change). RESULTS: Ten GF and 10 GI dogs were evaluated. There were statistically significant time: group interactions for hs‐cTnI (P = .02) and normalized left ventricular internal systolic diameter (LVIDsN; P = .02), with GF dogs showing larger decreases in these variables than GI dogs. Median (range) hs‐cTnI (ng/mL) for GF dogs was 0.141 (0.012‐0.224) at baseline and 0.092 (0.044‐0.137) at 1 y, and for GI dogs was 0.051 (0.016‐0.195) at baseline and 0.060 (0.022‐0.280) at 1 y. Median LVIDsN for GF dogs was 1.01 (0.70‐1.30) at baseline and 0.87 (0.79‐1.24) at 1 y, and for GI dogs was 1.05 (0.84‐1.21) at baseline and 1.10 (0.85‐1.28) at 1 y. CONCLUSIONS AND CLINICAL IMPORTANCE: Decreased hs‐cTnI and LVIDsN in GF dogs after diet change supports reversibility of these subclinical myocardial abnormalities. John Wiley & Sons, Inc. 2022-04-14 2022 /pmc/articles/PMC9151466/ /pubmed/35420218 http://dx.doi.org/10.1111/jvim.16416 Text en © 2022 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals LLC on behalf of American College of Veterinary Internal Medicine. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | SMALL ANIMAL Haimovitz, Dana Vereb, Michelle Freeman, Lisa Goldberg, Robert Lessard, Darleen Rush, John Adin, Darcy Effect of diet change in healthy dogs with subclinical cardiac biomarker or echocardiographic abnormalities |
title | Effect of diet change in healthy dogs with subclinical cardiac biomarker or echocardiographic abnormalities |
title_full | Effect of diet change in healthy dogs with subclinical cardiac biomarker or echocardiographic abnormalities |
title_fullStr | Effect of diet change in healthy dogs with subclinical cardiac biomarker or echocardiographic abnormalities |
title_full_unstemmed | Effect of diet change in healthy dogs with subclinical cardiac biomarker or echocardiographic abnormalities |
title_short | Effect of diet change in healthy dogs with subclinical cardiac biomarker or echocardiographic abnormalities |
title_sort | effect of diet change in healthy dogs with subclinical cardiac biomarker or echocardiographic abnormalities |
topic | SMALL ANIMAL |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9151466/ https://www.ncbi.nlm.nih.gov/pubmed/35420218 http://dx.doi.org/10.1111/jvim.16416 |
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