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Heart-brain synchronization breakdown in Parkinson’s disease

Heart rate variability (HRV) abnormalities are potential early biomarkers in Parkinson’s disease (PD) but their relationship with central autonomic network (CAN) activity is not fully understood. We analyzed the synchronization between HRV and brain activity in 31 PD patients and 21 age-matched heal...

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Autores principales: Iniguez, Martin, Jimenez-Marin, Antonio, Erramuzpe, Asier, Acera, Marian, Tijero, Beatriz, Murueta-Goyena, Ane, Del Pino, Rocio, Fernandez, Tamara, Carmona‑Abellan, Mar, Cabrera-Zubizarreta, Alberto, Gómez‑Esteban, Juan Carlos, Cortes, Jesus M., Gabilondo, Inigo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9151654/
https://www.ncbi.nlm.nih.gov/pubmed/35637221
http://dx.doi.org/10.1038/s41531-022-00323-w
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author Iniguez, Martin
Jimenez-Marin, Antonio
Erramuzpe, Asier
Acera, Marian
Tijero, Beatriz
Murueta-Goyena, Ane
Del Pino, Rocio
Fernandez, Tamara
Carmona‑Abellan, Mar
Cabrera-Zubizarreta, Alberto
Gómez‑Esteban, Juan Carlos
Cortes, Jesus M.
Gabilondo, Inigo
author_facet Iniguez, Martin
Jimenez-Marin, Antonio
Erramuzpe, Asier
Acera, Marian
Tijero, Beatriz
Murueta-Goyena, Ane
Del Pino, Rocio
Fernandez, Tamara
Carmona‑Abellan, Mar
Cabrera-Zubizarreta, Alberto
Gómez‑Esteban, Juan Carlos
Cortes, Jesus M.
Gabilondo, Inigo
author_sort Iniguez, Martin
collection PubMed
description Heart rate variability (HRV) abnormalities are potential early biomarkers in Parkinson’s disease (PD) but their relationship with central autonomic network (CAN) activity is not fully understood. We analyzed the synchronization between HRV and brain activity in 31 PD patients and 21 age-matched healthy controls using blood-oxygen-level-dependent (BOLD) signals from resting-state functional brain MRI and HRV metrics from finger plethysmography recorded for 7.40 min. We additionally quantified autonomic symptoms (SCOPA-AUT) and objective autonomic cardiovascular parameters (blood pressure and heart rate) during deep breathing, Valsalva, and head-up tilt, which were used to classify the clinical severity of dysautonomia. We evaluated HRV and BOLD signals synchronization (HRV-BOLD-sync) with Pearson lagged cross-correlations and Fisher’s statistics for combining window-length-dependent HRV-BOLD-Sync Maps and assessed their association with clinical dysautonomia. HRV-BOLD-sync was lower significantly in PD than in controls in various brain regions within CAN or in networks involved in autonomic modulation. Moreover, heart-brain synchronization index (HBSI), which quantifies heart-brain synchronization at a single-subject level, showed an inverse exposure–response relationship with dysautonomia severity, finding the lowest HBSI in patients with severe dysautonomia, followed by moderate, mild, and, lastly, controls. Importantly, HBSI was associated in PD, but not in controls, with Valsalva pressure recovery time (sympathetic), deep breathing E/I ratio (cardiovagal), and SCOPA-AUT. Our findings support the existence of heart-brain de-synchronization in PD with an impact on clinically relevant autonomic outcomes.
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spelling pubmed-91516542022-06-01 Heart-brain synchronization breakdown in Parkinson’s disease Iniguez, Martin Jimenez-Marin, Antonio Erramuzpe, Asier Acera, Marian Tijero, Beatriz Murueta-Goyena, Ane Del Pino, Rocio Fernandez, Tamara Carmona‑Abellan, Mar Cabrera-Zubizarreta, Alberto Gómez‑Esteban, Juan Carlos Cortes, Jesus M. Gabilondo, Inigo NPJ Parkinsons Dis Article Heart rate variability (HRV) abnormalities are potential early biomarkers in Parkinson’s disease (PD) but their relationship with central autonomic network (CAN) activity is not fully understood. We analyzed the synchronization between HRV and brain activity in 31 PD patients and 21 age-matched healthy controls using blood-oxygen-level-dependent (BOLD) signals from resting-state functional brain MRI and HRV metrics from finger plethysmography recorded for 7.40 min. We additionally quantified autonomic symptoms (SCOPA-AUT) and objective autonomic cardiovascular parameters (blood pressure and heart rate) during deep breathing, Valsalva, and head-up tilt, which were used to classify the clinical severity of dysautonomia. We evaluated HRV and BOLD signals synchronization (HRV-BOLD-sync) with Pearson lagged cross-correlations and Fisher’s statistics for combining window-length-dependent HRV-BOLD-Sync Maps and assessed their association with clinical dysautonomia. HRV-BOLD-sync was lower significantly in PD than in controls in various brain regions within CAN or in networks involved in autonomic modulation. Moreover, heart-brain synchronization index (HBSI), which quantifies heart-brain synchronization at a single-subject level, showed an inverse exposure–response relationship with dysautonomia severity, finding the lowest HBSI in patients with severe dysautonomia, followed by moderate, mild, and, lastly, controls. Importantly, HBSI was associated in PD, but not in controls, with Valsalva pressure recovery time (sympathetic), deep breathing E/I ratio (cardiovagal), and SCOPA-AUT. Our findings support the existence of heart-brain de-synchronization in PD with an impact on clinically relevant autonomic outcomes. Nature Publishing Group UK 2022-05-30 /pmc/articles/PMC9151654/ /pubmed/35637221 http://dx.doi.org/10.1038/s41531-022-00323-w Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Iniguez, Martin
Jimenez-Marin, Antonio
Erramuzpe, Asier
Acera, Marian
Tijero, Beatriz
Murueta-Goyena, Ane
Del Pino, Rocio
Fernandez, Tamara
Carmona‑Abellan, Mar
Cabrera-Zubizarreta, Alberto
Gómez‑Esteban, Juan Carlos
Cortes, Jesus M.
Gabilondo, Inigo
Heart-brain synchronization breakdown in Parkinson’s disease
title Heart-brain synchronization breakdown in Parkinson’s disease
title_full Heart-brain synchronization breakdown in Parkinson’s disease
title_fullStr Heart-brain synchronization breakdown in Parkinson’s disease
title_full_unstemmed Heart-brain synchronization breakdown in Parkinson’s disease
title_short Heart-brain synchronization breakdown in Parkinson’s disease
title_sort heart-brain synchronization breakdown in parkinson’s disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9151654/
https://www.ncbi.nlm.nih.gov/pubmed/35637221
http://dx.doi.org/10.1038/s41531-022-00323-w
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